DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp70Ab and HSPA5

DIOPT Version :10

Sequence 1:NP_524798.2 Gene:Hsp70Ab / 44920 FlyBaseID:FBgn0013276 Length:642 Species:Drosophila melanogaster
Sequence 2:NP_005338.1 Gene:HSPA5 / 3309 HGNCID:5238 Length:654 Species:Homo sapiens


Alignment Length:620 Identity:376/620 - (60%)
Similarity:485/620 - (78%) Gaps:14/620 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67
            :|||||||||||||:::|:|||||||||||.|||||||| :.||||||.||||:..||.||||||
Human    31 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 95

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEY-KGESKRFAPEEISSMVLTKMKETAEAY 131
            ||||||.::||.:.:|:|..|||||....||.|.|:. .|::|.|||||||:|||||||||||||
Human    96 KRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY 160

  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            ||:.:|.||:||||||||:|||||||||.||||||:||||||||||:||||||. :||:|:|:||
Human   161 LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKR-EGEKNILVFD 224

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRL 261
            |||||||||:||||.| :|||.:|.|||||||||||.|::.|....:|:|..||:|.:.||:::|
Human   225 LGGGTFDVSLLTIDNG-VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKL 288

  Fly   262 RTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDK 326
            |...|:|||.|||..:|.|||::.:||:||...::||:||||..||||:|::||:|.|.|:.:.|
Human   289 RREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKK 353

  Fly   327 GQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLL 391
            ..|.:||||||||||||:|.|:::||:||..:..|||||||||||||||.:|||||.  ..|::|
Human   354 SDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQD--TGDLVL 416

  Fly   392 VDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNNALGT 456
            :||.||:|||||.||||||||.||..:|.|:::.|||.:||||.|:|:||||||.:||||:.|||
Human   417 LDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGT 481

  Fly   457 FDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAE 521
            |||:||||||||||||||||::|.||||.|:|::..||....|||.||:.||:..||:||||:||
Human   482 FDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAE 546

  Fly   522 KYADEDEKHRQRITSRNALESYVFNVKQAV--EQAPAGKLDEADKNSVLDKCNDTIRWLDSNTTA 584
            |:|:||:|.::||.:||.||||.:::|..:  ::...|||...||.::.....:.|.||:|:..|
Human   547 KFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDA 611

  Fly   585 EKEEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGP 619
            :.|:|..|.:||.....||::|::      |:.||
Human   612 DIEDFKAKKKELEEIVQPIISKLY------GSAGP 640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70AbNP_524798.2 PTZ00009 2..642 CDD:240227 376/620 (61%)
HSPA5NP_005338.1 Required for interaction with ELAPOR1. /evidence=ECO:0000269|PubMed:26045166 1..80 39/48 (81%)
HSP70 30..635 CDD:394970 373/607 (61%)
Nucleotide-binding (NBD). /evidence=ECO:0000303|PubMed:28286085 125..280 111/156 (71%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 3/11 (27%)
Substrate-binding (SBD). /evidence=ECO:0000303|PubMed:28286085 420..500 57/79 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..654 4/14 (29%)
Prevents secretion from ER. /evidence=ECO:0000255 651..654
Blue background indicates that the domain is not in the aligned region.

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