DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp70Ab and HSPA1A

DIOPT Version :9

Sequence 1:NP_524798.2 Gene:Hsp70Ab / 44920 FlyBaseID:FBgn0013276 Length:642 Species:Drosophila melanogaster
Sequence 2:NP_005336.3 Gene:HSPA1A / 3303 HGNCID:5232 Length:641 Species:Homo sapiens


Alignment Length:648 Identity:486/648 - (75%)
Similarity:558/648 - (86%) Gaps:20/648 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67
            |||||||||||||||:|||||||||||||||||||||||||:||||||.||||||:||:||||||
Human     6 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDA 70

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132
            |||||||:.||.:..|||||||:|::||.|||:.|.||||:|.|.||||||||||||||.|||||
Human    71 KRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYL 135

  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197
            |..:|:|||||||||||||||||||||.|||||||||||||||||:|||||:..|||||||||||
Human   136 GYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDL 200

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRLR 262
            |||||||||||||:| :|||::|||||||||||||||||.|..:|||||:|||:..|.||:||||
Human   201 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLR 264

  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327
            ||.|||||||||||:|::|||:||||.||||.::||||||||:||||:||:||||||.|||:||.
Human   265 TACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKA 329

  Fly   328 QIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392
            ||||:|||||||||||||.||||||:|::||.|||||||||||||||||||.||:|..:||:||:
Human   330 QIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLL 394

  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNNALGTF 457
            ||||||||:||||||||.||:||..||.|||:.|:||:||||||.|||||||||||||||.||.|
Human   395 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRF 459

  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522
            :|||||||||||||||||||:||||||||:|.:.|||||..|||.|||||||:.||:|||.||||
Human   460 ELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEK 524

  Fly   523 YADEDEKHRQRITSRNALESYVFNVKQAVE-QAPAGKLDEADKNSVLDKCNDTIRWLDSNTTAEK 586
            |..|||..|:|::::||||||.||:|.||| :...||:.||||..|||||.:.|.|||:||.|||
Human   525 YKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEK 589

  Fly   587 EEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGPGANCGQQAGGFGGY-------SGPTVEEVD 642
            :||:||.:||.:.|:||::.::|     ||||||      .||||..       ||||:||||
Human   590 DEFEHKRKELEQVCNPIISGLYQ-----GAGGPG------PGGFGAQGPKGGSGSGPTIEEVD 641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70AbNP_524798.2 PTZ00009 2..642 CDD:240227 484/646 (75%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 308/375 (82%)
HSPA1ANP_005336.3 PTZ00009 1..611 CDD:240227 467/605 (77%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 311/380 (82%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 91/114 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..641 15/32 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H74294
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D180577at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 1 1.100 - - O PTHR19375
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.830

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