DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp70Ab and Hspa5

DIOPT Version :10

Sequence 1:NP_524798.2 Gene:Hsp70Ab / 44920 FlyBaseID:FBgn0013276 Length:642 Species:Drosophila melanogaster
Sequence 2:NP_037215.1 Gene:Hspa5 / 25617 RGDID:2843 Length:654 Species:Rattus norvegicus


Alignment Length:620 Identity:378/620 - (60%)
Similarity:486/620 - (78%) Gaps:14/620 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67
            :|||||||||||||:::|:|||||||||||.|||||||| :.||||||.||||:..||.||||||
  Rat    31 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 95

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEY-KGESKRFAPEEISSMVLTKMKETAEAY 131
            ||||||.::||.:.:|:|..|||||....||.|.|:. .|::|.|||||||:|||||||||||||
  Rat    96 KRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY 160

  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            ||:.:|.||:||||||||:|||||||||.||||||:||||||||||:||||||. :||:|:|:||
  Rat   161 LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKR-EGEKNILVFD 224

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRL 261
            |||||||||:||||.| :|||.:|.|||||||||||.|::.|....:|:|..||:|.:.||:::|
  Rat   225 LGGGTFDVSLLTIDNG-VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKL 288

  Fly   262 RTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDK 326
            |...|:|||.|||..:|.|||::.|||:||...::||:||||..||||:|::||:|.|.|:.:.|
  Rat   289 RREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKK 353

  Fly   327 GQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLL 391
            ..|.:||||||||||||:|.|:::||:||..:..|||||||||||||||.:|||||.  ..|::|
  Rat   354 SDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQD--TGDLVL 416

  Fly   392 VDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNNALGT 456
            :||.||:|||||.||||||||.||..:|.|:::.|||.:||||.|:|:||||||.:||||:.|||
  Rat   417 LDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGT 481

  Fly   457 FDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAE 521
            |||:||||||||||||||||::|.||||.|:|::..||....|||.||:.||:..||:||||:||
  Rat   482 FDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAE 546

  Fly   522 KYADEDEKHRQRITSRNALESYVFNVKQAV--EQAPAGKLDEADKNSVLDKCNDTIRWLDSNTTA 584
            |:|:||:|.::||.:||.||||.:::|..:  ::...|||...||.::.....:.|.||:|:..|
  Rat   547 KFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSPEDKETMEKAVEEKIEWLESHQDA 611

  Fly   585 EKEEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGP 619
            :.|:|..|.:||.....||::|::      |:|||
  Rat   612 DIEDFKAKKKELEEIVQPIISKLY------GSGGP 640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70AbNP_524798.2 PTZ00009 2..642 CDD:240227 378/620 (61%)
Hspa5NP_037215.1 Required for interaction with ELAPOR1. /evidence=ECO:0000250|UniProtKB:P11021 1..80 39/48 (81%)
HSP70 30..635 CDD:394970 374/607 (62%)
Nucleotide-binding (NBD). /evidence=ECO:0000250|UniProtKB:P11021 125..280 111/156 (71%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 3/11 (27%)
Substrate-binding (SBD). /evidence=ECO:0000250|UniProtKB:P11021 420..500 57/79 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..654 5/16 (31%)
Prevents secretion from ER 651..654
Blue background indicates that the domain is not in the aligned region.

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