Protein Alignment Hsp70Ab and Hspa9

DIOPT Version :10

• Sequence 1: NP_524798.2
• Gene: Hsp70Ab / 44920
• FlyBaseID: FBgn0013276
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_034611.2
• Gene: Hspa9 / 15526
• MGIID: 96245
• Length: 679
• Species: Mus musculus
• Alignment Length: 636
• Identity: 319/636 - (50%)
• Similarity: 423/636 - (66%)
• Gaps: 42/636 - (6%)

  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|.|||.|...||.||.:..
Mouse    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEA 130
            ||||||:||||::.:|.|:.|||:|  |:|   ...||..|  |.::|.:|.:.||.|||||||.
Mouse   121 KRLIGRRYDDPEVQKDTKNVPFKIVRASNG---DAWVEAHG--KLYSPSQIGAFVLMKMKETAEN 180

  Fly   131 YLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIF 195
            |||.:..:|||||||||||||||||||||.|:||||||:|||||||||||||||:  .::.:.::
Mouse   181 YLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVY 243

  Fly   196 DLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRR 260
            ||||||||:|||.|.:| :|||:||.|||.|||||||..|:.|:..||||:...||..:..||:|
Mouse   244 DLGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQR 307

  Fly   261 LRTAAERAKRTLSSSTEATIEIDALFEG----QDFYTKVSRARFEELCADLFRNTLQPVEKALND 321
            :|.|||:||..||||.:..|.:..|...    :....|::||:||.:..||.:.|:.|.:||:.|
Mouse   308 VREAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNMKLTRAQFEGIVTDLIKRTIAPCQKAMQD 372

  Fly   322 AKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKI 386
            |::.|..|.:::||||.||:||||..:||.| |:..:.::|||||||.|||:|..:|:||    :
Mouse   373 AEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD----V 432

  Fly   387 QDVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDN 451
            .||||:||.||||||||.|||.||||.||..||.|:::.|||.||.|..|.|:|.:|||.|..||
Mouse   433 TDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDN 497

  Fly   452 NALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRM 516
            ..||.|.|.|||||||||||||||||:|||||::||||:..||:.:.|.|:: .|.||:.:|:.|
Mouse   498 KLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDIENM 561

  Fly   517 VNEAEKYADEDEKHRQRITSRNALESYVFNVKQAVE----QAPAGKLDEADK-NSVLDKCNDTIR 576
            |..|||||:||.:.::|:.:.|..|..:.:.:..:|    |.||   ||.:| ...:.|....:.
Mouse   562 VKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPA---DECNKLKEEISKMRALLA 623

  Fly   577 WLDSNT-------TAEKEEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGPG 620
            ..||.|       .:..::...||.|:.      ..||..:..|:|:.|.|
Mouse   624 GKDSETGENIRQAASSLQQASLKLFEMA------YKKMASEREGSGSSGTG 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ab	NP_524798.2	PTZ00009	2..642	CDD:240227	319/636 (50%)
Hspa9	NP_034611.2	Interaction with NFS1. /evidence=ECO:0000250|UniProtKB:P38646	1..432		208/388 (54%)
		dnaK	52..673	CDD:234715	319/636 (50%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P38646	63..431		200/376 (53%)
		Interaction with FXN and ISCU. /evidence=ECO:0000250|UniProtKB:P38646	432..679		111/247 (45%)
		Interdomain linker. /evidence=ECO:0000250|UniProtKB:P38646	432..441		5/8 (63%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P38646	442..679		105/237 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		4/13 (31%)