Protein Alignment Hsp70Ab and HSPA12B

DIOPT Version :10

• Sequence 1: NP_524798.2
• Gene: Hsp70Ab / 44920
• FlyBaseID: FBgn0013276
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_443202.3
• Gene: HSPA12B / 116835
• HGNCID: 16193
• Length: 686
• Species: Homo sapiens
• Alignment Length: 661
• Identity: 141/661 - (21%)
• Similarity: 231/661 - (34%)
• Gaps: 205/661 - (31%)

  Fly     4 IGIDLGTTYSCVGVYQHGKVEII-------ANDQG--NRTTPSYVAFTDSERLIGDPAKNQVAMN 59
            :.||.|||.|..........|.|       ..|.|  ::.||:.:..|.      :.|.:.....
Human    63 VAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTP------EGAFHSFGYT 121

  Fly    60 PRNTVFDAKRLIGRKYDDPKIAEDMKHW-PFKV----VSD----------GGKPKIGVEYKGESK 109
            .|:...|.         ||:.|.|..:: .||:    .:|          .||....:|....:.
Human   122 ARDYYHDL---------DPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKTMPALEVFAHAL 177

  Fly   110 RFAPEEISSMVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGL------NVLR 168
            ||..|.    .|.:::|.:.:...:.....|:||||.:....:|..::|.::|||      ..|.
Human   178 RFFREH----ALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQFMREAAYLAGLVSRENAEQLL 238

  Fly   169 IINEPTAAAL----------------AYG---------LDKNLK--------------------- 187
            |..||.||::                |.|         :|.:.:
Human   239 IALEPEAASVYCRKLRLHQLLDLSGRAPGGGRLGERRSIDSSFRQAREQLRRSRHSRTFLVESGV 303

  Fly   188 ---------GERNVLIFDLGGGTFDVSILTIDE--GSLFEV-RSTAGDTHLGGED--FDNRLVTH 238
                     |:|.| :.|.||||.|:::..:::  |:|.|: :::.|.....|.|  |:..|...
Human   304 GELWAEMQAGDRYV-VADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRI 367

  Fly   239 LADEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFE-- 301
            ..::|...:|   |..|.|...|..|.|..|||........:.|...|...|||.|......|
Human   368 FGEDFIATFK---RQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETA 429

  Fly   302 ---------------------ELCADLFRNT----LQPVEKALNDAKMDKGQIHDIVLVGGSTRI 341
                                 |...:||:.|    :|.:|..|  |:.:...:..:.||||....
Human   430 LRRSSVNFVKWSSQGMLRMSCEAMNELFQPTVSGIIQHIEALL--ARPEVQGVKLLFLVGGFAES 492

  Fly   342 PKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGIETAGG 406
            ..:|..:|.....:.|.:.:..|..:   ..::.|:|.|...|    |:.|..:||:.|:    |
Human   493 AVLQHAVQAALGARGLRVVVPHDVGL---TILKGAVLFGQAPG----VVRVRRSPLTYGV----G 546

  Fly   407 VMT----------KLIERNCRIPCKQTKTFS-----------------TYADNQPG---VSIQVY 441
            |:.          ||:.|:.|..|  |..|.                 :|...:||   |.|.:|
Human   547 VLNRFVPGRHPPEKLLVRDGRRWC--TDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLY 609

  Fly   442 ----EGERAMT----KDNNALGT--------FDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKE 490
                |..|.:|    :...||..        .|.:|.||..|.:.......|.:    :.|:|.:
Human   610 CCAAEDARFITDPGVRKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFGDTE----IKVTAVD 670

  Fly   491 MSTGKAKNITI 501
            :||.::...:|
Human   671 VSTNRSVRASI 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ab	NP_524798.2	PTZ00009	2..642	CDD:240227	141/661 (21%)
HSPA12B	NP_443202.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	12..53
		ASKHA_NBD_HSP70_HSPA12B	61..528	CDD:466842	103/492 (21%)