DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp70Ab and HSPA12B

DIOPT Version :9

Sequence 1:NP_524798.2 Gene:Hsp70Ab / 44920 FlyBaseID:FBgn0013276 Length:642 Species:Drosophila melanogaster
Sequence 2:NP_443202.3 Gene:HSPA12B / 116835 HGNCID:16193 Length:686 Species:Homo sapiens


Alignment Length:661 Identity:141/661 - (21%)
Similarity:231/661 - (34%) Gaps:205/661 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IGIDLGTTYSCVGVYQHGKVEII-------ANDQG--NRTTPSYVAFTDSERLIGDPAKNQVAMN 59
            :.||.|||.|..........|.|       ..|.|  ::.||:.:..|.      :.|.:.....
Human    63 VAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTP------EGAFHSFGYT 121

  Fly    60 PRNTVFDAKRLIGRKYDDPKIAEDMKHW-PFKV----VSD----------GGKPKIGVEYKGESK 109
            .|:...|.         ||:.|.|..:: .||:    .:|          .||....:|....:.
Human   122 ARDYYHDL---------DPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKTMPALEVFAHAL 177

  Fly   110 RFAPEEISSMVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGL------NVLR 168
            ||..|.    .|.:::|.:.:...:.....|:||||.:....:|..::|.::|||      ..|.
Human   178 RFFREH----ALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQFMREAAYLAGLVSRENAEQLL 238

  Fly   169 IINEPTAAAL----------------AYG---------LDKNLK--------------------- 187
            |..||.||::                |.|         :|.:.:                     
Human   239 IALEPEAASVYCRKLRLHQLLDLSGRAPGGGRLGERRSIDSSFRQAREQLRRSRHSRTFLVESGV 303

  Fly   188 ---------GERNVLIFDLGGGTFDVSILTIDE--GSLFEV-RSTAGDTHLGGED--FDNRLVTH 238
                     |:|.| :.|.||||.|:::..:::  |:|.|: :::.|.....|.|  |:..|...
Human   304 GELWAEMQAGDRYV-VADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRI 367

  Fly   239 LADEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFE-- 301
            ..::|...:|   |..|.|...|..|.|..|||........:.|...|...|||.|......|  
Human   368 FGEDFIATFK---RQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETA 429

  Fly   302 ---------------------ELCADLFRNT----LQPVEKALNDAKMDKGQIHDIVLVGGSTRI 341
                                 |...:||:.|    :|.:|..|  |:.:...:..:.||||....
Human   430 LRRSSVNFVKWSSQGMLRMSCEAMNELFQPTVSGIIQHIEALL--ARPEVQGVKLLFLVGGFAES 492

  Fly   342 PKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGIETAGG 406
            ..:|..:|.....:.|.:.:..|..:   ..::.|:|.|...|    |:.|..:||:.|:    |
Human   493 AVLQHAVQAALGARGLRVVVPHDVGL---TILKGAVLFGQAPG----VVRVRRSPLTYGV----G 546

  Fly   407 VMT----------KLIERNCRIPCKQTKTFS-----------------TYADNQPG---VSIQVY 441
            |:.          ||:.|:.|..|  |..|.                 :|...:||   |.|.:|
Human   547 VLNRFVPGRHPPEKLLVRDGRRWC--TDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLY 609

  Fly   442 ----EGERAMT----KDNNALGT--------FDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKE 490
                |..|.:|    :...||..        .|.:|.||..|.:.......|.:    :.|:|.:
Human   610 CCAAEDARFITDPGVRKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFGDTE----IKVTAVD 670

  Fly   491 MSTGKAKNITI 501
            :||.::...:|
Human   671 VSTNRSVRASI 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70AbNP_524798.2 PTZ00009 2..642 CDD:240227 141/661 (21%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 102/491 (21%)
HSPA12BNP_443202.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 12..53
NBD_sugar-kinase_HSP70_actin 61..529 CDD:327376 103/493 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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