Protein Alignment DNApol-alpha60 and PRI2

DIOPT Version :9

• Sequence 1: NP_652001.2
• Gene: DNApol-alpha60 / 44915
• FlyBaseID: FBgn0259676
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_012879.1
• Gene: PRI2 / 853821
• SGDID: S000001528
• Length: 528
• Species: Saccharomyces cerevisiae
• Alignment Length: 497
• Identity: 149/497 - (29%)
• Similarity: 254/497 - (51%)
• Gaps: 52/497 - (10%)

  Fly     5 LKKRARHEVKVEVASLETKYPHNVMLYHYPPTEDVHIDEFEELALERLRLLRVLDRASTRNLRVL 69
            |...:..|.|...|.|   |...:..|..||..::.:::||..|::||::|..::...:||..:
Yeast    39 LSSSSSEEEKKLYARL---YESKLSFYDLPPQGEITLEQFEIWAIDRLKILLEIESCLSRNKSI- 99

  Fly    70 SDEWKEIVSADLTREGLRSYLRLCSTGGSAKHEADIQTRRRDYLSHFILRLAYCRSEDLARWFVA 134
                |||.:  :.:...:..|..        :...::.|::||.|||||||.:|||::|...||.
Yeast   100 ----KEIET--IIKPQFQKLLPF--------NTESLEDRKKDYYSHFILRLCFCRSKELREKFVR 150

  Fly   135 REMELFRYKFAALSSFEVKQFLEANGFE-IHPLTEAQKDEVKDGLYESTVGQSVAKIELLD---- 194
            .|..||:.:|..|:|.:..:|:::.... :..::..:|.|:...||::.......::.|.:
Yeast   151 AETFLFKIRFNMLTSTDQTKFVQSLDLPLLQFISNEEKAELSHQLYQTVSASLQFQLNLNEEHQR 215

  Fly   195 --------FYKVPFTQVLDLVRGRRCFLKAGYAYVNTHDLVSLVGTKQQDEIEQGLQAAKTMVED 251
                    |.|:||..|::||..|..|||.||||:.....::|:..:...::.|.|......:..
Yeast   216 KQYFQQEKFIKLPFENVIELVGNRLVFLKDGYAYLPQFQQLNLLSNEFASKLNQELIKTYQYLPR 280

  Fly   252 VEADERISRTLKALHNSYTGRDYTVCR--------DAAVPIESL--DQLSKTSMPLCMRMCHEHI 306
            :..|:|:...|..|.:.||..|:...:        |..:..:|:  :::| ::.|||::...|.:
Yeast   281 LNEDDRLLPILNHLSSGYTIADFNQQKANQFSENVDDEINAQSVWSEEIS-SNYPLCIKNLMEGL 344

  Fly   307 RANHHIKHSGRMQYGLFLKGIGVALEDSLRFWREEFTK--KMDADKFTRSYEYNIYHNYGKKGSM 369
            :.|||:::.||.|..|||||||::.:::|:||.|.||:  .|..:||.:.|.|:..||||.:|:.
Yeast   345 KKNHHLRYYGRQQLSLFLKGIGLSADEALKFWSEAFTRNGNMTMEKFNKEYRYSFRHNYGLEGNR 409

  Fly   370 VNYTPYSCAKII-KDVAGPGDCHGCPYKNMDQGSLKTKLSSYGLSASAIDEVMFFVSRGHYQIGC 433
            :||.|:.|..|: |...|.||.||||:::.....|..:|.|..|:.:.|..|:....:|.|.|.|
Yeast   410 INYKPWDCHTILSKPRPGRGDYHGCPFRDWSHERLSAELRSMKLTQAQIISVLDSCQKGEYTIAC 474

  Fly   434 GKYFQLTHNSP-------VEPSINHPNNYFEESQIAMGNRQK 468
            .|.|::||||.       .:..|.|||.|||.|:.....:||
Yeast   475 TKVFEMTHNSASADLEIGEQTHIAHPNLYFERSRQLQKKQQK 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha60	NP_652001.2	PriL_PriS_Eukaryotic	30..459	CDD:143474	140/461 (30%)
PRI2	NP_012879.1	PriL_PriS_Eukaryotic	61..507	CDD:143474	140/461 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346498
Domainoid	1	1.000	172	1.000	Domainoid score	I766
eggNOG	1	0.900	-	-		E1_COG2219
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H731
Inparanoid	1	1.050	232	1.000	Inparanoid score	I725
Isobase	1	0.950	-	0	Normalized mean entropy	S1310
OMA	1	1.010	-	-		QHG53502
OrthoFinder	1	1.000	-	-		FOG0005104
OrthoInspector	1	1.000	-	-		oto100006
orthoMCL	1	0.900	-	-		OOG6_102391
Panther	1	1.100	-	-	LDO	PTHR10537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R981
SonicParanoid	1	1.000	-	-		X3626
TreeFam	1	0.960	-	-
	16	15.740