DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-alpha60 and prim2

DIOPT Version :9

Sequence 1:	NP_652001.2	Gene:	DNApol-alpha60 / 44915	FlyBaseID:	FBgn0259676	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_999947.1	Gene:	prim2 / 407653	ZFINID:	ZDB-GENE-050522-471	Length:	508	Species:	Danio rerio

Alignment Length:	525	Identity:	201/525 - (38%)
Similarity:	303/525 - (57%)	Gaps:	50/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEF-GLKKRARHEVKVEVASLETKYPHNVMLYHYPPTEDVHIDEFEELALERLRLLRVLDRASTR 64
            |:| |.:|      |:..:|....|.|.:..|..||.:::.:.|||..|:|||:||:.::.....
Zfish     1 MQFLGRRK------KLISSSQSDLYDHCLQFYGQPPLDNISLIEFETFAVERLKLLKTVENLGVS 59

  Fly    65 NLRVLSDEWKEIVSADLTREGLRSYLRLCSTGGSAKHEAD----------IQTRRRDYLSHFILR 119
            .::. :|::.:.:.|:           ..|.....:.|.|          .:.||:|::||||||
Zfish    60 YVKT-TDQYIKKLEAE-----------FLSLNFPFRAEVDDRKVPGVTSEYEKRRKDHISHFILR 112

  Fly   120 LAYCRSEDLARWFVAREMELFRYKFAALSSFEVKQFLEANGFEIHPLTEAQKDEVKDGLYESTVG 184
            ||||::|||.|||:.:||:||||:|..|||....:||..|..:...::..:|..::|.|..|:.|
Zfish   113 LAYCQTEDLRRWFIQQEMDLFRYRFGILSSKHKTEFLHKNNLKYETVSAEEKKNLRDKLINSSYG 177

  Fly   185 QSVAKIELLDFYKVPFTQVLDLVRGRRCFLKAGYAYVNTHDLVSLVGTKQQDEIEQGLQAAKTMV 249
            .|...:|..|||:|||...|||||.|:.:|.||.||:..:::|::|....:..:.:.|......:
Zfish   178 LSGITLEEYDFYRVPFQDALDLVRTRKVYLLAGNAYIPQNEIVTIVLNDFRTRLSKALAVTARSL 242

  Fly   250 EDVEADERISRTLKALHNSYTGRDYTVCRDAA-VPIESLDQLSKTSMPLCMRMCHEHIRANHHIK 313
            ..|::|||:...|..|.::|.|:||::.::.. :.:|.:|.||..|.|||||..|:.:|.|||::
Zfish   243 PAVQSDERLQPLLSHLSHAYVGQDYSIQKNVGKISLEQIDPLSGKSFPLCMRHLHKALRENHHLR 307

  Fly   314 HSGRMQYGLFLKGIGVALEDSLRFWREEFTK-KMDADKFTRSYEYNIYHNYGKKGSMVNYTPYSC 377
            |.|||||||||||||:.||.:::|||.||.| |:|||||.::|.|:|.|.:||:|...:||||||
Zfish   308 HGGRMQYGLFLKGIGLTLEQAMQFWRSEFVKGKVDADKFDKAYAYSIRHMFGKEGKRTDYTPYSC 372

  Fly   378 AKIIKDVAGP---GDCHGCPYKNMDQGSLKTKLSSYGLSASAIDEVMFFVSRGHYQIGCGKYFQL 439
            .|:|  ::.|   ||.||||:::.|...||.||.||.::...|::::..|...|||:.|.|||:|
Zfish   373 MKVI--LSNPPSQGDYHGCPFRHSDPELLKQKLQSYKIAPGGINQILELVKGMHYQLACQKYFEL 435

  Fly   440 THNSPVEP---SINHPNNYFEESQIAMGNRQ--------KRANGSAPPKARIRPDIKGHGDRSML 493
            ||:  ||.   |:||||.||.|||..:|..|        .:.:...||.|. ||...........
Zfish   436 THS--VEDAGFSLNHPNQYFTESQKLLGGGQGIKKEVEMSQKSQENPPSAS-RPSQANPKQAQEE 497

  Fly   494 MGDDD 498
            |||.|
Zfish   498 MGDLD 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha60	NP_652001.2	PriL_PriS_Eukaryotic	30..459	CDD:143474	179/446 (40%)
prim2	NP_999947.1	PriL_PriS_Eukaryotic	25..456	CDD:143474	179/446 (40%)
prim2	NP_999947.1	PRI2	36..418	CDD:225129	156/395 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595907
Domainoid	1	1.000	252	1.000	Domainoid score	I2051
eggNOG	1	0.900	-	-		E1_COG2219
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H731
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2170
OMA	1	1.010	-	-		QHG53502
OrthoDB	1	1.010	-	-		D222812at33208
OrthoFinder	1	1.000	-	-		FOG0005104
OrthoInspector	1	1.000	-	-		oto41364
orthoMCL	1	0.900	-	-		OOG6_102391
Panther	1	1.100	-	-	LDO	PTHR10537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R981
SonicParanoid	1	1.000	-	-		X3626
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800