DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-alpha60 and spp2

DIOPT Version :9

Sequence 1:	NP_652001.2	Gene:	DNApol-alpha60 / 44915	FlyBaseID:	FBgn0259676	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_596380.1	Gene:	spp2 / 2539933	PomBaseID:	SPBC17D11.06	Length:	459	Species:	Schizosaccharomyces pombe

Alignment Length:	451	Identity:	158/451 - (35%)
Similarity:	248/451 - (54%)	Gaps:	22/451 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ASLET-KYPHNVMLYHYPPTEDVHIDEFEELALERLRLLRVLDRASTRNLRVLSDEWKEIVSADL 81
            ||.|: .||..:..|..||..::.|:|||..|::||.:|..::.|..||  ...:|...|:...|
pombe    19 ASFESLSYPTRLNFYKKPPVSEISIEEFETWAIDRLVVLGEIESAMLRN--KTKNELNGIIKKIL 81

  Fly    82 -TREGLRSYLRLCSTGGSAKHEADIQTRRRDYLSHFILRLAYCRSEDLARWFVAREMELFRYKFA 145
             .|..:.|.:.....|.|...|     ||:|:.||||||||:.||::|...|:..|..|||::|.
pombe    82 DKRLPMSSNMARTVKGNSLDEE-----RRKDHYSHFILRLAFSRSDELRIRFLRAESTLFRFRFV 141

  Fly   146 ALSSFEVKQFLEANGFEIHPLTEAQKDEVKDGLYESTVGQSVAKIELLDFYKVPFTQVLDLVRGR 210
            ...:.|.:.|:::..|:    .|:...|.||..||.....|...||...|:||||.:|.|||..|
pombe   142 NEETRERQAFIDSLDFQ----WESVSQEEKDVFYEKLQASSQRNIENESFFKVPFFKVPDLVERR 202

  Fly   211 RCFLKAGYAYVNTHDLVSLVGTKQQDEIEQGLQAAKTMVEDVEADERISRTLKALHNSYTGRDYT 275
            ..|:..|||||...:.||||..:.::.:::.|::....:..::.|:|:...|..|...:...:.:
pombe   203 AVFVHKGYAYVPFSEQVSLVVEEFEENLKKALESTAKSLPRLDEDDRLLPILNHLSKGFVAPESS 267

  Fly   276 VC--RDAAVPIESLDQLSKTSMPLCMRMCHEHIRANHHIKHSGRMQYGLFLKGIGVALEDSLRFW 338
            :.  :..|:....:|.. .:..|||.:..||.::.:.|::|.||:|||||||.||::::::|.||
pombe   268 IVAPKSGAITAGQVDSF-VSHFPLCAKHLHEVLKRDKHLRHFGRLQYGLFLKDIGLSVDEALVFW 331

  Fly   339 REEFTKKMDADKFTRSYEYNIYHNYGKKGSMVNYTPYSCAKIIK-DVAGPGDCHGCPYKNMDQGS 402
            |:.|| .:..|||.:.|.|||.|.||.:|:..||..|:|.:|:. ...||||.|||||:.....:
pombe   332 RKSFT-NVTEDKFNKEYRYNIRHTYGLEGNRKNYKGYNCQQILTGPQLGPGDAHGCPYRTYSVNN 395

  Fly   403 LKTKLSSYGLS--ASAIDEVMFFVSRGHYQIGCGKYFQLTHNS--PVEPSINHPNNYFEES 459
            |.:.|:|.|::  ::...||:..|...||.|.|.:.|:|||.:  .:|.||:||..||:.|
pombe   396 LVSALASMGIAPDSAGCREVVEAVKARHYHIACTRVFELTHPNVGSLEESIHHPLQYFQLS 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha60	NP_652001.2	PriL_PriS_Eukaryotic	30..459	CDD:143474	152/436 (35%)
spp2	NP_596380.1	PRI2	26..396	CDD:225129	132/382 (35%)
spp2	NP_596380.1	PriL_PriS_Eukaryotic	32..456	CDD:143474	152/436 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	185	1.000	Domainoid score	I779
eggNOG	1	0.900	-	-		E1_COG2219
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H731
Inparanoid	1	1.050	256	1.000	Inparanoid score	I761
OMA	1	1.010	-	-		QHG53502
OrthoFinder	1	1.000	-	-		FOG0005104
OrthoInspector	1	1.000	-	-		oto101730
orthoMCL	1	0.900	-	-		OOG6_102391
Panther	1	1.100	-	-	LDO	PTHR10537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R981
SonicParanoid	1	1.000	-	-		X3626
TreeFam	1	0.960	-	-
	14	13.860