DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-45 and TOM71

DIOPT Version :9

Sequence 1:NP_001303425.1 Gene:unc-45 / 44910 FlyBaseID:FBgn0010812 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_011985.1 Gene:TOM71 / 856517 SGDID:S000001159 Length:639 Species:Saccharomyces cerevisiae


Alignment Length:603 Identity:137/603 - (22%)
Similarity:219/603 - (36%) Gaps:154/603 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SEEVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVE 71
            |:..:.|...|::||..|.|..:.||:::|..||:.....   .|||.|.:|.|:..|..|..:|
Yeast   121 SQRQAYAVQLKNRGNHFFTAKNFNEAIKYYQYAIELDPNE---PVFYSNISACYISTGDLEKVIE 182

  Fly    72 DCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATAL-FKADPGNKTVQPMLQR------LHV 129
            ..|::|:..|...|||.|||.|.|:|..|.:|..|.:.| ...|....:::|||:|      :.|
Yeast   183 FTTKALEIKPDHSKALLRRASANESLGNFTDAMFDLSVLSLNGDFDGASIEPMLERNLNKQAMKV 247

  Fly   130 VVEERSARNAKTSTKVKQMMDLT-----FDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIA 189
            :.|..|....:.|..:.....|.     ||....:.....::|.....|......:.||......
Yeast   248 LNENLSKDEGRGSQVLPSNTSLASFFGIFDSHLEVSSVNTSSNYDTAYALLSDALQRLYSATDEG 312

  Fly   190 KVASLTKVEKDQDIYVNMVHLVAALCENSV-----ERTKGVLTELGVPWFMRVLDQKHENCVSTA 249
            .:.:...:.|..|:|.::      |..|:|     |.....|...|:..|::       |.:..|
Yeast   313 YLVANDLLTKSTDMYHSL------LSANTVDDPLRENAALALCYTGIFHFLK-------NNLLDA 364

  Fly   250 QFCLQTILNALSGLKNKPDSKPEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELITRN 314
            |..||..:|    |...|:|                 ...|..::.|:..|........:.:..|
Yeast   365 QVLLQESIN----LHPTPNS-----------------YIFLALTLADKENSQEFFKFFQKAVDLN 408

  Fly   315 VHYTALEWAERLVEIRGLCRLLDVCSELEDYK-----YESAMDITGSS--STIASVCLARIYE-- 370
            ..|....:.      ||....:     |:|||     ::.|..:...:  ..|...||  :|:  
Yeast   409 PEYPPTYYH------RGQMYFI-----LQDYKNAKEDFQKAQSLNPENVYPYIQLACL--LYKQG 460

  Fly   371 -----NMYYDEAKARF--------------TDQ--IDEYIKDKLLA---PDMESKVRVTVAITAL 411
                 ..:::|.|.:|              ||:  .|..||...:|   .:::.|:.|.:     
Yeast   461 KFTESEAFFNETKLKFPTLPEVPTFFAEILTDRGDFDTAIKQYDIAKRLEEVQEKIHVGI----- 520

  Fly   412 LNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLIAASSKKDKAKALCEQGVDILKRLY 476
              ||| :|...         |||..::.|..|  :..|...||.....||   ||.         
Yeast   521 --GPL-IGKAT---------ILARQSSQDPTQ--LDEEKFNAAIKLLTKA---CEL--------- 559

  Fly   477 HSKNDGIRVRALVGLCKLGSYGGQ-DAAIRPFGDGAAL------KL-----AEAC---RRF---- 522
                |....:|.:||.:|.....: |.||..|.|.|.|      ||     |||.   :|.    
Yeast   560 ----DPRSEQAKIGLAQLKLQMEKIDEAIELFEDSAILARTMDEKLQATTFAEAAKIQKRLRADP 620

  Fly   523 LIKPGKDKDIRRWAADGL 540
            :|....:..:.|:.|.|:
Yeast   621 IISAKMELTLARYRAKGM 638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-45NP_001303425.1 TPR_11 12..81 CDD:290150 22/68 (32%)
TPR repeat 16..41 CDD:276809 9/24 (38%)
TPR repeat 46..79 CDD:276809 11/32 (34%)
TPR_11 50..115 CDD:290150 25/65 (38%)
TPR 50..83 CDD:197478 12/32 (38%)
UNC45-central 351..494 CDD:288539 35/170 (21%)
ARM 668..788 CDD:237987
armadillo repeat 753..789 CDD:293788
armadillo repeat 795..826 CDD:293788
TOM71NP_011985.1 3a0801s09 9..636 CDD:273380 135/599 (23%)
TPR repeat 127..155 CDD:276809 10/27 (37%)
TPR repeat 160..190 CDD:276809 11/32 (34%)
TPR repeat 195..218 CDD:276809 11/22 (50%)
TPR repeat 345..373 CDD:276809 8/34 (24%)
TPR repeat 378..406 CDD:276809 5/44 (11%)
TPR repeat 411..441 CDD:276809 8/40 (20%)
TPR repeat 446..471 CDD:276809 4/26 (15%)
TPR repeat 480..508 CDD:276809 6/27 (22%)
TPR repeat 513..559 CDD:276809 17/67 (25%)
TPR repeat 564..588 CDD:276809 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157345418
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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