DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-45 and TOM71

DIOPT Version :10

Sequence 1:NP_524796.1 Gene:unc-45 / 44910 FlyBaseID:FBgn0288846 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_011985.1 Gene:TOM71 / 856517 SGDID:S000001159 Length:639 Species:Saccharomyces cerevisiae


Alignment Length:603 Identity:137/603 - (22%)
Similarity:219/603 - (36%) Gaps:154/603 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SEEVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVE 71
            |:..:.|...|::||..|.|..:.||:::|..||:.....   .|||.|.:|.|:..|..|..:|
Yeast   121 SQRQAYAVQLKNRGNHFFTAKNFNEAIKYYQYAIELDPNE---PVFYSNISACYISTGDLEKVIE 182

  Fly    72 DCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATAL-FKADPGNKTVQPMLQR------LHV 129
            ..|::|:..|...|||.|||.|.|:|..|.:|..|.:.| ...|....:::|||:|      :.|
Yeast   183 FTTKALEIKPDHSKALLRRASANESLGNFTDAMFDLSVLSLNGDFDGASIEPMLERNLNKQAMKV 247

  Fly   130 VVEERSARNAKTSTKVKQMMDLT-----FDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIA 189
            :.|..|....:.|..:.....|.     ||....:.....::|.....|......:.||......
Yeast   248 LNENLSKDEGRGSQVLPSNTSLASFFGIFDSHLEVSSVNTSSNYDTAYALLSDALQRLYSATDEG 312

  Fly   190 KVASLTKVEKDQDIYVNMVHLVAALCENSV-----ERTKGVLTELGVPWFMRVLDQKHENCVSTA 249
            .:.:...:.|..|:|.::      |..|:|     |.....|...|:..|::       |.:..|
Yeast   313 YLVANDLLTKSTDMYHSL------LSANTVDDPLRENAALALCYTGIFHFLK-------NNLLDA 364

  Fly   250 QFCLQTILNALSGLKNKPDSKPEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELITRN 314
            |..||..:|    |...|:|                 ...|..::.|:..|........:.:..|
Yeast   365 QVLLQESIN----LHPTPNS-----------------YIFLALTLADKENSQEFFKFFQKAVDLN 408

  Fly   315 VHYTALEWAERLVEIRGLCRLLDVCSELEDYK-----YESAMDITGSS--STIASVCLARIYE-- 370
            ..|....:.      ||....:     |:|||     ::.|..:...:  ..|...||  :|:  
Yeast   409 PEYPPTYYH------RGQMYFI-----LQDYKNAKEDFQKAQSLNPENVYPYIQLACL--LYKQG 460

  Fly   371 -----NMYYDEAKARF--------------TDQ--IDEYIKDKLLA---PDMESKVRVTVAITAL 411
                 ..:::|.|.:|              ||:  .|..||...:|   .:::.|:.|.:     
Yeast   461 KFTESEAFFNETKLKFPTLPEVPTFFAEILTDRGDFDTAIKQYDIAKRLEEVQEKIHVGI----- 520

  Fly   412 LNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLIAASSKKDKAKALCEQGVDILKRLY 476
              ||| :|...         |||..::.|..|  :..|...||.....||   ||.         
Yeast   521 --GPL-IGKAT---------ILARQSSQDPTQ--LDEEKFNAAIKLLTKA---CEL--------- 559

  Fly   477 HSKNDGIRVRALVGLCKLGSYGGQ-DAAIRPFGDGAAL------KL-----AEAC---RRF---- 522
                |....:|.:||.:|.....: |.||..|.|.|.|      ||     |||.   :|.    
Yeast   560 ----DPRSEQAKIGLAQLKLQMEKIDEAIELFEDSAILARTMDEKLQATTFAEAAKIQKRLRADP 620

  Fly   523 LIKPGKDKDIRRWAADGL 540
            :|....:..:.|:.|.|:
Yeast   621 IISAKMELTLARYRAKGM 638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-45NP_524796.1 3a0801s09 7..>127 CDD:273380 42/126 (33%)
TPR repeat 16..41 CDD:276809 9/24 (38%)
TPR repeat 46..79 CDD:276809 11/32 (34%)
UNC45-central 351..494 CDD:432011 35/170 (21%)
PLN03200 399..>700 CDD:215629 40/161 (25%)
armadillo repeat 753..789 CDD:293788
armadillo repeat 795..826 CDD:293788
TOM71NP_011985.1 3a0801s09 9..636 CDD:273380 135/599 (23%)
TPR repeat 127..155 CDD:276809 10/27 (37%)
TPR repeat 160..190 CDD:276809 11/32 (34%)
TPR repeat 195..218 CDD:276809 11/22 (50%)
TPR repeat 345..373 CDD:276809 8/34 (24%)
TPR repeat 378..406 CDD:276809 5/44 (11%)
TPR repeat 411..441 CDD:276809 8/40 (20%)
TPR repeat 446..471 CDD:276809 4/26 (15%)
TPR repeat 480..508 CDD:276809 6/27 (22%)
TPR repeat 513..559 CDD:276809 17/67 (25%)
TPR repeat 564..588 CDD:276809 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

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