DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-45 and TOM70

DIOPT Version :10

Sequence 1:NP_524796.1 Gene:unc-45 / 44910 FlyBaseID:FBgn0288846 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_014278.3 Gene:TOM70 / 855602 SGDID:S000005065 Length:617 Species:Saccharomyces cerevisiae


Alignment Length:612 Identity:132/612 - (21%)
Similarity:220/612 - (35%) Gaps:229/612 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 NTINSEEVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYE 67
            |....|:...|.:.|||||:.|:..::::|:::|..|::.    ||..|||.|.:|.|:.:|..:
Yeast    89 NFTAEEKDKYALALKDKGNQFFRNKKYDDAIKYYNWALEL----KEDPVFYSNLSACYVSVGDLK 149

  Fly    68 NAVEDCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATAL-FKADPGNKTVQPMLQRLHVVV 131
            ..||..|::|:..|...|.|.|||.|.|.|.||.:|..|.:.| ...|..:.:::|||:|     
Yeast   150 KVVEMSTKALELKPDYSKVLLRRASANEGLGKFADAMFDLSVLSLNGDFNDASIEPMLER----- 209

  Fly   132 EERSARNAKTSTKVKQMM-DLTFDLATPID-------KRRAAANNLVVLAKEQTGAELLYKDHCI 188
                ..|.:..:|:|:.. |:....|||.:       :|:....||                ..:
Yeast   210 ----NLNKQAMSKLKEKFGDIDTATATPTELSTQPAKERKDKQENL----------------PSV 254

  Fly   189 AKVASLTKVEKDQDIYVNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCL 253
            ..:||...:.|.:..:.|                               .|:.:|        ..
Yeast   255 TSMASFFGIFKPELTFAN-------------------------------YDESNE--------AD 280

  Fly   254 QTILNALSGL-KNKPDSKPE------------KELCTRNNREIDTLLTCLVYSITDRTI------ 299
            :.::|.||.| |..|:|..:            :|...:|| |.:.|...|..|:....|      
Yeast   281 KELMNGLSNLYKRSPESYDKADESFTKAARLFEEQLDKNN-EDEKLKEKLAISLEHTGIFKFLKN 344

  Fly   300 --SGAARD--GVIELITR--NVHYTALEWAERLVEIRGLCRLLDVCSELEDYKYESAMDITGSSS 358
              .||..|  ..|||..|  :..|.||..|:|           :..:|..:| ::.|:.:..::|
Yeast   345 DPLGAHEDIKKAIELFPRVNSYIYMALIMADR-----------NDSTEYYNY-FDKALKLDSNNS 397

  Fly   359 T------------------------------------IASVCLARIYENMY------YDEAKARF 381
            :                                    |...||| ..||.:      :.|||.:|
Yeast   398 SVYYHRGQMNFILQNYDQAGKDFDKAKELDPENIFPYIQLACLA-YRENKFDDCETLFSEAKRKF 461

  Fly   382 --------------TDQ--IDEYIKDKLLAPDMESK---VRVTVA-----ITALLNGP------- 415
                          ||:  .|:.:|...||.::|:|   :.|.:|     .|.|...|       
Yeast   462 PEAPEVPNFFAEILTDKNDFDKALKQYDLAIELENKLDGIYVGIAPLVGKATLLTRNPTVENFIE 526

  Fly   416 ----------LDVGNQVVAREGILQMILAMATTDD----------------------------EL 442
                      ||..:: .|:.|:.||.|.....|:                            ::
Yeast   527 ATNLLEKASKLDPRSE-QAKIGLAQMKLQQEDIDEAITLFEESADLARTMEEKLQAITFAEAAKV 590

  Fly   443 QQRVSCECLIAASSKKDKAKALCEQGV 469
            |||:..:.::|...::..|| |.|||:
Yeast   591 QQRIRSDPVLAKKIQETLAK-LREQGL 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-45NP_524796.1 3a0801s09 7..>127 CDD:273380 42/120 (35%)
TPR repeat 16..41 CDD:276809 9/24 (38%)
TPR repeat 46..79 CDD:276809 13/32 (41%)
UNC45-central 351..494 CDD:432011 42/230 (18%)
PLN03200 399..>700 CDD:215629 25/124 (20%)
armadillo repeat 753..789 CDD:293788
armadillo repeat 795..826 CDD:293788
TOM70NP_014278.3 3a0801s09 1..614 CDD:273380 129/608 (21%)
TPR repeat 99..127 CDD:276809 10/27 (37%)
TPR repeat 131..161 CDD:276809 11/29 (38%)
TPR repeat 166..189 CDD:276809 11/22 (50%)
TPR repeat 330..358 CDD:276809 5/27 (19%)
TPR repeat 363..391 CDD:276809 8/39 (21%)
TPR repeat 396..426 CDD:276809 1/29 (3%)
TPR repeat 431..459 CDD:276809 8/28 (29%)
TPR repeat 465..493 CDD:276809 6/27 (22%)
TPR repeat 498..537 CDD:276809 5/38 (13%)
TPR repeat 542..567 CDD:276809 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

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