DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc-45 and TOM70

DIOPT Version :9

Sequence 1:NP_001303425.1 Gene:unc-45 / 44910 FlyBaseID:FBgn0010812 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_014278.3 Gene:TOM70 / 855602 SGDID:S000005065 Length:617 Species:Saccharomyces cerevisiae


Alignment Length:612 Identity:132/612 - (21%)
Similarity:220/612 - (35%) Gaps:229/612 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 NTINSEEVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYE 67
            |....|:...|.:.|||||:.|:..::::|:::|..|::.    ||..|||.|.:|.|:.:|..:
Yeast    89 NFTAEEKDKYALALKDKGNQFFRNKKYDDAIKYYNWALEL----KEDPVFYSNLSACYVSVGDLK 149

  Fly    68 NAVEDCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATAL-FKADPGNKTVQPMLQRLHVVV 131
            ..||..|::|:..|...|.|.|||.|.|.|.||.:|..|.:.| ...|..:.:::|||:|     
Yeast   150 KVVEMSTKALELKPDYSKVLLRRASANEGLGKFADAMFDLSVLSLNGDFNDASIEPMLER----- 209

  Fly   132 EERSARNAKTSTKVKQMM-DLTFDLATPID-------KRRAAANNLVVLAKEQTGAELLYKDHCI 188
                ..|.:..:|:|:.. |:....|||.:       :|:....||                ..:
Yeast   210 ----NLNKQAMSKLKEKFGDIDTATATPTELSTQPAKERKDKQENL----------------PSV 254

  Fly   189 AKVASLTKVEKDQDIYVNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCL 253
            ..:||...:.|.:..:.|                               .|:.:|        ..
Yeast   255 TSMASFFGIFKPELTFAN-------------------------------YDESNE--------AD 280

  Fly   254 QTILNALSGL-KNKPDSKPE------------KELCTRNNREIDTLLTCLVYSITDRTI------ 299
            :.::|.||.| |..|:|..:            :|...:|| |.:.|...|..|:....|      
Yeast   281 KELMNGLSNLYKRSPESYDKADESFTKAARLFEEQLDKNN-EDEKLKEKLAISLEHTGIFKFLKN 344

  Fly   300 --SGAARD--GVIELITR--NVHYTALEWAERLVEIRGLCRLLDVCSELEDYKYESAMDITGSSS 358
              .||..|  ..|||..|  :..|.||..|:|           :..:|..:| ::.|:.:..::|
Yeast   345 DPLGAHEDIKKAIELFPRVNSYIYMALIMADR-----------NDSTEYYNY-FDKALKLDSNNS 397

  Fly   359 T------------------------------------IASVCLARIYENMY------YDEAKARF 381
            :                                    |...||| ..||.:      :.|||.:|
Yeast   398 SVYYHRGQMNFILQNYDQAGKDFDKAKELDPENIFPYIQLACLA-YRENKFDDCETLFSEAKRKF 461

  Fly   382 --------------TDQ--IDEYIKDKLLAPDMESK---VRVTVA-----ITALLNGP------- 415
                          ||:  .|:.:|...||.::|:|   :.|.:|     .|.|...|       
Yeast   462 PEAPEVPNFFAEILTDKNDFDKALKQYDLAIELENKLDGIYVGIAPLVGKATLLTRNPTVENFIE 526

  Fly   416 ----------LDVGNQVVAREGILQMILAMATTDD----------------------------EL 442
                      ||..:: .|:.|:.||.|.....|:                            ::
Yeast   527 ATNLLEKASKLDPRSE-QAKIGLAQMKLQQEDIDEAITLFEESADLARTMEEKLQAITFAEAAKV 590

  Fly   443 QQRVSCECLIAASSKKDKAKALCEQGV 469
            |||:..:.::|...::..|| |.|||:
Yeast   591 QQRIRSDPVLAKKIQETLAK-LREQGL 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-45NP_001303425.1 TPR_11 12..81 CDD:290150 23/68 (34%)
TPR repeat 16..41 CDD:276809 9/24 (38%)
TPR repeat 46..79 CDD:276809 13/32 (41%)
TPR_11 50..115 CDD:290150 25/65 (38%)
TPR 50..83 CDD:197478 12/32 (38%)
UNC45-central 351..494 CDD:288539 42/230 (18%)
ARM 668..788 CDD:237987
armadillo repeat 753..789 CDD:293788
armadillo repeat 795..826 CDD:293788
TOM70NP_014278.3 3a0801s09 1..614 CDD:273380 129/608 (21%)
TPR repeat 99..127 CDD:276809 10/27 (37%)
TPR repeat 131..161 CDD:276809 11/29 (38%)
TPR repeat 166..189 CDD:276809 11/22 (50%)
TPR repeat 330..358 CDD:276809 5/27 (19%)
TPR repeat 363..391 CDD:276809 8/39 (21%)
TPR repeat 396..426 CDD:276809 1/29 (3%)
TPR repeat 431..459 CDD:276809 8/28 (29%)
TPR repeat 465..493 CDD:276809 6/27 (22%)
TPR repeat 498..537 CDD:276809 5/38 (13%)
TPR repeat 542..567 CDD:276809 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157345419
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.