DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc-45 and SHE4

DIOPT Version :9

Sequence 1:NP_001303425.1 Gene:unc-45 / 44910 FlyBaseID:FBgn0010812 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_014678.1 Gene:SHE4 / 854200 SGDID:S000005561 Length:789 Species:Saccharomyces cerevisiae


Alignment Length:879 Identity:175/879 - (19%)
Similarity:325/879 - (36%) Gaps:203/879 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 ERSARNAKTSTKVKQMMDLTFDLATPID--KRRAAANNLVVLAKEQTGAELL---YKDHCIAKVA 192
            :::.::.....|....::..|.|....:  |..|...|...|...|...|:|   |:||..::|.
Yeast    24 DKTLKSTPDVQKYNDAINTIFQLRQKSESGKMPADLTNSEALKDRQKIEEILTRSYQDHSESRVH 88

  Fly   193 SLTKVEKDQDIYVNM--------VHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTA 249
            ....::.|....:|:        :|:... |.::.:.|..:|.||.:    |:    |....:..
Yeast    89 LSKLIQNDIPFALNLFEILSRSSIHVFVG-CFSNKDATIALLNELQI----RI----HYGEDTHV 144

  Fly   250 QFCLQTILNALSGLKNKPDSKP----EKELCTR-NNREIDTLLTCL---VYSITDRTISGAARDG 306
            .:.|..||..|:  |.|.:.|.    .|||..| :..|:.:::..:   :.|...:....|..|.
Yeast   145 TYLLSIILQLLN--KFKYNFKEVRFLVKELILRISEDEVKSMMLIIFAELQSSFQKDFDKAVVDF 207

  Fly   307 VIELITRNVHYTALEWAERLVEIRGLCRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYEN 371
            :..||..         ||..|....|..::...|||    |.|.  .|..|....:..|:::::.
Yeast   208 MSSLIVE---------AEIDVGNDPLSIIVKTLSEL----YPSL--TTLCSEIFLTKGLSKLFKK 257

  Fly   372 MYYDEAKARFTDQIDEYIKDKLLAPDMESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMA 436
            ..::|...:||.::...:....:  |...:..:|.....||...|:|.:        :|:..|:.
Yeast   258 RVFEEQDLQFTKELLRLLSSACI--DETMRTYITENYLQLLERSLNVED--------VQIYSALV 312

  Fly   437 TTDDELQQRVSCECLIAASSKKDKAKALCEQGVDILKRLYHSKNDGIRVRALVGLCKLGSYGGQD 501
            ........:::|..|          |.|.|..::.:.|....|.:.:                  
Yeast   313 LVKTWSFTKLTCINL----------KQLSEIFINAISRRIMPKIENV------------------ 349

  Fly   502 AAIRPFGDGAALKLAEACRRFLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDL 566
                   :.:|:||.|.       |..:..:     :.||||:|.|..|..:..:::....|:.:
Yeast   350 -------NESAVKLEEV-------PKVEMSV-----EALAYLSLKASVKIMIRSNESFTEILLTM 395

  Fly   567 ARGGNQS-CLYGVVTTFVNLCNAYEKQEMLPEMI-ELAKFAKQHIP-------EEHELDDVDFIN 622
            .:....: ||||::....||....|:.....:.| :|..:|....|       |:...:|:...|
Yeast   396 IKSQKMTHCLYGLLVIMANLSTLPEESNGSSQSINDLKNYADLKGPGADKVGAEKESKEDILLFN 460

  Fly   623 KRITVLANEGITTALCALAKTESH----NSQELIARVLNAVCGLKELRGKVVQEGGVKALLRMAL 683
            ::..      :.|.|.:..|.|.|    |.::.:.||:..:...|....:.:.:||...:|....
Yeast   461 EKYI------LRTELISFLKREMHNLSPNCKQQVVRVIYNITRSKNFIPQCISQGGTTIILEYLA 519

  Fly   684 EGTEKG---KRHATQALARIGITINPEVSFSGQRSLDVIRPLLNLL-------------QQDCTA 732
            ...:.|   :....:||.|:.|..||.:.|....:|:.|..|..||             .:....
Yeast   520 NKQDIGEPIRILGCRALTRMLIFTNPGLIFKKYSALNAIPFLFELLPRSTPVDDNPLHNDEQIKL 584

  Fly   733 LENFESLMALTNLASMNESVRQRIIKEQGVSK-----IEYYLMEDHLYLTRAAAQCLCNLVMSED 792
            .:|:|:|:|||||||...|..:.:.|....:|     ||..::::::.|.|:..:.:.|::....
Yeast   585 TDNYEALLALTNLASSETSDGEEVCKHIVSTKVYWSTIENLMLDENVPLQRSTLELISNMMSHPL 649

  Fly   793 VI--KMFEGNNDR--------VKFLALLCEDEDEETATACAGALAIITSVSVKCCEKILAIASWL 847
            .|  |.|...|.:        ||.|.|    .|.|:..|.|...|.|.:.       |..||..|
Yeast   650 TIAAKFFNLENPQSLRNFNILVKLLQL----SDVESQRAVAAIFANIATT-------IPLIAKEL 703

  Fly   848 DILHTLIANPSPAVQHRGIVIILNMINAGEEIAKKLFETDIMELLSGLGQLPDDTRAKAREVATQ 912
            .....||.|   |:|     :..:.|: ..|:.::|     :.|..||                 
Yeast   704 LTKKELIEN---AIQ-----VFADQID-DIELRQRL-----LMLFFGL----------------- 737

  Fly   913 CLAAAERYRIIERSDNAEIPDVFAENSKISEIID 946
                   :.:|..:...|:..:..||.|:.:.::
Yeast   738 -------FEVIPDNGTNEVYPLLQENQKLKDALN 764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-45NP_001303425.1 TPR_11 12..81 CDD:290150
TPR repeat 16..41 CDD:276809
TPR repeat 46..79 CDD:276809
TPR_11 50..115 CDD:290150
TPR 50..83 CDD:197478
UNC45-central 351..494 CDD:288539 21/142 (15%)
ARM 668..788 CDD:237987 34/140 (24%)
armadillo repeat 753..789 CDD:293788 7/40 (18%)
armadillo repeat 795..826 CDD:293788 11/38 (29%)
SHE4NP_014678.1 UNC45-central 167..316 CDD:403029 33/173 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 66 1.000 Domainoid score I2394
eggNOG 1 0.900 - - E1_KOG4151
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002389
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103191
Panther 1 1.100 - - LDO PTHR45994
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.810

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