Protein Alignment unc-45 and SHE4

DIOPT Version :10

• Sequence 1: NP_524796.1
• Gene: unc-45 / 44910
• FlyBaseID: FBgn0288846
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_014678.1
• Gene: SHE4 / 854200
• SGDID: S000005561
• Length: 789
• Species: Saccharomyces cerevisiae
• Alignment Length: 879
• Identity: 175/879 - (19%)
• Similarity: 325/879 - (36%)
• Gaps: 203/879 - (23%)

  Fly   133 ERSARNAKTSTKVKQMMDLTFDLATPID--KRRAAANNLVVLAKEQTGAELL---YKDHCIAKVA 192
            :::.::.....|....::..|.|....:  |..|...|...|...|...|:|   |:||..::|.
Yeast    24 DKTLKSTPDVQKYNDAINTIFQLRQKSESGKMPADLTNSEALKDRQKIEEILTRSYQDHSESRVH 88

  Fly   193 SLTKVEKDQDIYVNM--------VHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTA 249
            ....::.|....:|:        :|:... |.::.:.|..:|.||.:    |:    |....:..
Yeast    89 LSKLIQNDIPFALNLFEILSRSSIHVFVG-CFSNKDATIALLNELQI----RI----HYGEDTHV 144

  Fly   250 QFCLQTILNALSGLKNKPDSKP----EKELCTR-NNREIDTLLTCL---VYSITDRTISGAARDG 306
            .:.|..||..|:  |.|.:.|.    .|||..| :..|:.:::..:   :.|...:....|..|.
Yeast   145 TYLLSIILQLLN--KFKYNFKEVRFLVKELILRISEDEVKSMMLIIFAELQSSFQKDFDKAVVDF 207

  Fly   307 VIELITRNVHYTALEWAERLVEIRGLCRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYEN 371
            :..||..         ||..|....|..::...|||    |.|.  .|..|....:..|:::::.
Yeast   208 MSSLIVE---------AEIDVGNDPLSIIVKTLSEL----YPSL--TTLCSEIFLTKGLSKLFKK 257

  Fly   372 MYYDEAKARFTDQIDEYIKDKLLAPDMESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMA 436
            ..::|...:||.::...:....:  |...:..:|.....||...|:|.:        :|:..|:.
Yeast   258 RVFEEQDLQFTKELLRLLSSACI--DETMRTYITENYLQLLERSLNVED--------VQIYSALV 312

  Fly   437 TTDDELQQRVSCECLIAASSKKDKAKALCEQGVDILKRLYHSKNDGIRVRALVGLCKLGSYGGQD 501
            ........:::|..|          |.|.|..::.:.|....|.:.:
Yeast   313 LVKTWSFTKLTCINL----------KQLSEIFINAISRRIMPKIENV------------------ 349

  Fly   502 AAIRPFGDGAALKLAEACRRFLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDL 566
                   :.:|:||.|.       |..:..:     :.||||:|.|..|..:..:::....|:.:
Yeast   350 -------NESAVKLEEV-------PKVEMSV-----EALAYLSLKASVKIMIRSNESFTEILLTM 395

  Fly   567 ARGGNQS-CLYGVVTTFVNLCNAYEKQEMLPEMI-ELAKFAKQHIP-------EEHELDDVDFIN 622
            .:....: ||||::....||....|:.....:.| :|..:|....|       |:...:|:...|
Yeast   396 IKSQKMTHCLYGLLVIMANLSTLPEESNGSSQSINDLKNYADLKGPGADKVGAEKESKEDILLFN 460

  Fly   623 KRITVLANEGITTALCALAKTESH----NSQELIARVLNAVCGLKELRGKVVQEGGVKALLRMAL 683
            ::..      :.|.|.:..|.|.|    |.::.:.||:..:...|....:.:.:||...:|....
Yeast   461 EKYI------LRTELISFLKREMHNLSPNCKQQVVRVIYNITRSKNFIPQCISQGGTTIILEYLA 519

  Fly   684 EGTEKG---KRHATQALARIGITINPEVSFSGQRSLDVIRPLLNLL-------------QQDCTA 732
            ...:.|   :....:||.|:.|..||.:.|....:|:.|..|..||             .:....
Yeast   520 NKQDIGEPIRILGCRALTRMLIFTNPGLIFKKYSALNAIPFLFELLPRSTPVDDNPLHNDEQIKL 584

  Fly   733 LENFESLMALTNLASMNESVRQRIIKEQGVSK-----IEYYLMEDHLYLTRAAAQCLCNLVMSED 792
            .:|:|:|:|||||||...|..:.:.|....:|     ||..::::::.|.|:..:.:.|::....
Yeast   585 TDNYEALLALTNLASSETSDGEEVCKHIVSTKVYWSTIENLMLDENVPLQRSTLELISNMMSHPL 649

  Fly   793 VI--KMFEGNNDR--------VKFLALLCEDEDEETATACAGALAIITSVSVKCCEKILAIASWL 847
            .|  |.|...|.:        ||.|.|    .|.|:..|.|...|.|.:.       |..||..|
Yeast   650 TIAAKFFNLENPQSLRNFNILVKLLQL----SDVESQRAVAAIFANIATT-------IPLIAKEL 703

  Fly   848 DILHTLIANPSPAVQHRGIVIILNMINAGEEIAKKLFETDIMELLSGLGQLPDDTRAKAREVATQ 912
            .....||.|   |:|     :..:.|: ..|:.::|     :.|..||
Yeast   704 LTKKELIEN---AIQ-----VFADQID-DIELRQRL-----LMLFFGL----------------- 737

  Fly   913 CLAAAERYRIIERSDNAEIPDVFAENSKISEIID 946
                   :.:|..:...|:..:..||.|:.:.::
Yeast   738 -------FEVIPDNGTNEVYPLLQENQKLKDALN 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_524796.1	3a0801s09	7..>127	CDD:273380
		TPR repeat	16..41	CDD:276809
		TPR repeat	46..79	CDD:276809
		UNC45-central	351..494	CDD:432011	21/142 (15%)
		PLN03200	399..>700	CDD:215629	56/316 (18%)
		armadillo repeat	753..789	CDD:293788	7/40 (18%)
		armadillo repeat	795..826	CDD:293788	11/38 (29%)
SHE4	NP_014678.1	UNC45-central	167..316	CDD:432011	33/173 (19%)