DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-45 and SPATA16

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_114161.3	Gene:	SPATA16 / 83893	HGNCID:	29935	Length:	569	Species:	Homo sapiens

Alignment Length:	452	Identity:	84/452 - (18%)
Similarity:	158/452 - (34%)	Gaps:	128/452 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VSDAGS-YKDKGNEAFKASRWEEAVEHYGKAIKAGSKH-------KELAVFYKNR-AAAYLKLGK 65
            :.||.| |:.| ..|..|.::..|:|...|....|...       ..:|.|.:.: ...||::.|
Human   180 LKDASSCYRQK-KYALAAGQFRTALELCSKGAVLGEPFDAPAEDIASVASFIETKLVTCYLRMRK 243

  Fly    66 YENAVEDCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATA---LFKADPGNKTVQPMLQRL 127
            .:.|:.....|:...|...:...|:|..:..||::.||.:.|..   :|....|.:.....|.:|
Human   244 PDLALNHAHRSIVLNPAYFRNHLRQATVFRCLERYSEAARSAMIADYMFWLGGGREESISKLIKL 308

  Fly   128 H--VVVEERSARNAKTSTKVKQMMDLTFDLATPI-DKRRAAANNLVVLAKEQTGAELLYKDHCIA 189
            :  .::||...|....|.           :.||. .|.||
Human   309 YWQAMIEEAITRAESFSV-----------MYTPFATKIRA------------------------- 337

  Fly   190 KVASLTKVEKDQDIYVNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQ 254
                 .|:||.:|.:.. .|...|         :.:.|:|..   :.:|.|    .|..:.|..|
Human   338 -----DKIEKVKDAFTK-THPAYA---------EYMYTDLQA---LHMLPQ----TVDWSSFPPQ 380

  Fly   255 TILNALSGLKNKPDSKPEKELCTR------------------NNREIDTL---LTCLVYSITDRT 298
            ..|..| |.|||.|.|..:::.:|                  ..|:::|:   :..::..|....
Human   381 QYLLTL-GFKNKDDGKFLEKISSRKLPIFTEHKTPFGLTREDTVRQMETMGKRILPILDFIRSTQ 444

  Fly   299 ISGA--ARDGVIELITRNVHYTALEWAERLVEIRGLCRLLD-VCSELEDYKYESAMDITGSSSTI 360
            ::|:  |..||:|    .:.|.:|  ..:|..::...:::: ..:||....|  ..||:...:.:
Human   445 LNGSFPASSGVME----KLQYASL--LSQLQRVKEQSQVINQAMAELATIPY--LQDISQQEAEL 501

  Fly   361 ASVCLARIYENMYYDEAKARFTDQI------------------DEYIKDKLLAPDMESKVRV 404
            ....:|...:.:   |.:....:::                  |.::|.|.|......|.::
Human   502 LQSLMADAMDTL---EGRRNNNERVWNMIQKVGQIEDFLYQLEDSFLKTKKLRTARRQKTKM 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	18/77 (23%)
		TPR repeat	16..41	CDD:276809	7/24 (29%)
		TPR repeat	46..79	CDD:276809	7/40 (18%)
		TPR_11	50..115	CDD:290150	16/68 (24%)
		TPR	50..83	CDD:197478	8/33 (24%)
		UNC45-central	351..494	CDD:288539	9/72 (13%)
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
SPATA16	NP_114161.3	NYD-SP12_N	6..567	CDD:291676	84/452 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..96
		TPR repeat	217..257	CDD:276809	7/39 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930