Protein Alignment unc-45 and Phox3

DIOPT Version :10

• Sequence 1: NP_524796.1
• Gene: unc-45 / 44910
• FlyBaseID: FBgn0288846
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_197536.1
• Gene: Phox3 / 832158
• AraportID: AT5G20360
• Length: 809
• Species: Arabidopsis thaliana
• Alignment Length: 778
• Identity: 142/778 - (18%)
• Similarity: 254/778 - (32%)
• Gaps: 285/778 - (36%)

  Fly    10 VSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSK-HKELAVFYKNRAAAYLKL--GKYENAVE 71
            ||.|...|::||:.|:...::.|:..||:|||...| |.|::....|.|:.|::|  |::..|:.
plant   123 VSKAQGLKEEGNKLFQKRDYDGAMFKYGEAIKILPKDHVEVSHVRANVASCYMQLEPGEFAKAIH 187

  Fly    72 DCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSA 136
            :|..:|...|...|||.:||:.||||.|.:.|.:|...:.|.||.|.....::::|...:|.:..
plant   188 ECDLALSVTPDHNKALLKRARCYEALNKLDLALRDVCMVSKLDPKNPMASEIVEKLKRTLESKGL 252

  Fly   137 RNAKTSTKVKQMMDLTFDLATPIDKRRAA--------------ANNLVVLAKEQTGAELLYKDHC 187
            |...:      :::|..|...|:....||              .:|.|....|..|.::
plant   253 RINNS------VIELPPDYVEPVGASPAALWAKLGKVRVKKTKKSNQVEEKSEGEGEDV------ 305

  Fly   188 IAKVASLTKVEKDQDIYVNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFC 252
                    :.||..::          |.|...|:.|           |:|..::.:....|::..
plant   306 --------EPEKKNNV----------LAEKGKEKIK-----------MKVKGKQSDKRSDTSKEQ 341

  Fly   253 LQTILN---ALSGLKNKPDSKPEKELCTRNNREIDTLLTCLVYSITD---------RTISGAARD 305
            .:.|:.   .:.|:::.  :|..|.:.:.:.|..:..:.|.::.:.:         |.:....||
plant   342 EKVIIEEELLVIGVEDV--NKDVKFVYSDDIRLAELPINCTLFKLREVVHERFPSLRAVHIKYRD 404

  Fly   306 GVIELIT-----------------RNVHYTALE-------WAERLVEI----------------R 330
            ...:|:|                 ..:.:..:|       :..||||:                |
plant   405 QEGDLVTITTDEELRMSEVSSRSQGTMRFYVVEVSPEQDPFFGRLVEMKKLKITADSFKAKVNGR 469

  Fly   331 GLCRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDEYIKDKLLA 395
            |.|:       :||:..|.|                      :..:.:||...  |..:..:.|.
plant   470 GGCK-------VEDWMIEFA----------------------HLFKIQARIDS--DRCLNLQELG 503

  Fly   396 PDMESKVRVTVAITALLNGPLDVGNQ----VVARE----------------GILQMILAMATTDD 440
            ..:.|:....|..:....||.|...|    |.||.                .:||.:...:.::
plant   504 MKLNSEAMEEVVTSDAAQGPFDRAAQQFQEVAARSLLNLGYVHMSGARKRLSLLQGVSGESVSE- 567

  Fly   441 ELQQRVSCECLIAASSKKDKAKALCEQGVDILKRLYHSKNDGIRVRALVGLCKLGSYGGQDAAIR 505
              |.:.:.||     :||:.|.|         |..|..
plant   568 --QVKTAYEC-----AKKEHANA---------KEKYEE--------------------------- 589

  Fly   506 PFGDGAALKLAEACRRFLIKPGKDK----------------DIRRWAADGLAYLTLDAECKEKLI 554
                  |:|:...|....:..|..:                |::.|....:......||.
plant   590 ------AMKIKPECFEVFLALGLQQFEEARLSWYYVLVSHLDLKTWPYADVVQFYQSAES----- 643

  Fly   555 EDKASIHALMDLARG--------GNQSCL-----------------YGVVTTFVN--LCNA-YEK 591
            ..|.|:..|.:|..|        |...||                 .|.:.::::  ||.. ||:
plant   644 NIKKSMEVLENLETGKESEPSQAGKTDCLTHEKDLGSSTQNNPAKEAGRLKSWIDILLCAVLYER 708

  Fly   592 Q---------------EMLPEMIELAKFAKQHIPE--------EHELDDVDFINKRITVLANE 631
            .               |...|..|||...|..:.|        .:.|.|:.|..:.|..:.:|
plant   709 SIMEYKLDQPFWRESLEAAMEKFELAGTCKDDVVEIISEDYVAGNTLRDIRFHMEEIIQIFDE 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_524796.1	3a0801s09	7..>127	CDD:273380	41/119 (34%)
		TPR repeat	16..41	CDD:276809	8/24 (33%)
		TPR repeat	46..79	CDD:276809	10/34 (29%)
		UNC45-central	351..494	CDD:432011	24/162 (15%)
		PLN03200	399..>700	CDD:215629	53/320 (17%)
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
Phox3	NP_197536.1	NlpI	<126..>237	CDD:443815	39/110 (35%)
		TPR repeat	126..154	CDD:276809	9/27 (33%)
		TPR repeat	159..195	CDD:276809	10/35 (29%)
		PB1	361..436	CDD:214770	8/74 (11%)