DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-45 and Spata16

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_083426.1	Gene:	Spata16 / 70862	MGIID:	1918112	Length:	571	Species:	Mus musculus

Alignment Length:	459	Identity:	99/459 - (21%)
Similarity:	159/459 - (34%)	Gaps:	141/459 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VSDAGS-YKDKGNEAFKASRWEEAVEHYGKAIKAG---SKHKE----LAVFYKNR-AAAYLKLGK 65
            :.||.| |:.| ..|..|.::..|:|...|....|   ..|.|    :|.|.:.: ...||::.|
Mouse   181 LKDASSCYRQK-KYAVAAGQFRTALELCSKGAALGKPFEAHAEDIASIASFIETKLVTCYLRMRK 244

  Fly    66 YENAVEDCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATA---LFKADPGNKTVQPMLQRL 127
            .:.|:.....|:...|...:...|:|..:..||::.||.:.|..   :|....|::.....|.:|
Mouse   245 PDLALNHAHRSIVLNPAYFRNHLRQAAVFRCLERYSEAARSAMIADYMFWLCGGSEHSVSKLIKL 309

  Fly   128 H--VVVEERSARNAKTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAK 190
            :  .::||     |.|..:...:|...|  ||.|..........|.:....|..:.:|.|
Mouse   310 YWQAMIEE-----AITRAEAFSVMYTPF--ATRIKPENIEKVKEVFMRTHPTYVDCIYTD----- 362

  Fly   191 VASLTKVEKDQDIYVNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHE-NCVSTAQFCLQ 254
                                           |:|          :.||.|..: :|....|:.|.
Mouse   363 -------------------------------TQG----------LHVLPQTADWSCFPPQQYLLT 386

  Fly   255 TILNALSGLKNKPDSKPEKELCTRN--------------NREIDT----------LLTCLVYSIT 295
            .      |.|||.|.|..:::.:|.              .|| ||          :|..|.: |.
Mouse   387 L------GFKNKEDGKFLEKVSSRKLPTYTEHKTPFSPLTRE-DTVRHMETVGKRILPILDF-IR 443

  Fly   296 DRTISG--AARDGVIELITRNVHYTAL--------EWA----ERLVEIRGLCRLLDVC---SELE 343
            ...::|  .|..||:|    .:||.:|        |.|    :.:.|:..:..|.|:.   :||.
Mouse   444 STQLNGNFHACSGVME----KLHYASLLSRLQRVKEQAQVINQAMAELATVPYLQDISQQEAELL 504

  Fly   344 DYKYESAMD-ITGSSS-------TIASVCLARIYENMYYDEAKARFTDQIDEYIKDKLLAPDMES 400
            ......||| :.|..|       ||..|  .||.:.:|..|         |.::|.|.|......
Mouse   505 QSLMADAMDTLEGKKSDKERVWNTIQKV--GRIEDFLYQLE---------DSFLKTKKLRTARRQ 558

  Fly   401 KVRV 404
            |.::
Mouse   559 KTKM 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	20/77 (26%)
		TPR repeat	16..41	CDD:276809	7/24 (29%)
		TPR repeat	46..79	CDD:276809	9/37 (24%)
		TPR_11	50..115	CDD:290150	16/68 (24%)
		TPR	50..83	CDD:197478	8/33 (24%)
		UNC45-central	351..494	CDD:288539	16/62 (26%)
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
Spata16	NP_083426.1	NYD-SP12_N	6..569	CDD:291676	99/459 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..58
		TPR_11	178..260	CDD:290150	20/79 (25%)
		TPR repeat	210..258	CDD:276809	10/47 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930