DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-45 and Sugt1

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_080750.1	Gene:	Sugt1 / 67955	MGIID:	1915205	Length:	336	Species:	Mus musculus

Alignment Length:	413	Identity:	80/413 - (19%)
Similarity:	149/413 - (36%)	Gaps:	136/413 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTESLKAAPGDPKALFRR--AQ 92
            :.|:|...||::   ::.:.|.:|..||..::.||||.:.:.|..:||:..|.:..||.|:  .:
Mouse    28 QAALEELTKALE---QNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICE 89

  Fly    93 AYE-----ALEKFEEAYK-DATALFKADPGNKTVQPMLQRLHVVVEERSARNAKTSTKVKQMMDL 151
            .:|     |||.|.|..| |:|     |....|.....|.:....|...:.:.:|.:|:|
Mouse    90 YHEKDYASALETFAEGQKLDST-----DTNFDTWIKRCQEIQNGSESEVSASQRTQSKIK----- 144

  Fly   152 TFDLATPIDKRRAAAN---NLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQDIYVNMVHLVAA 213
                   .|..:..::   .|::.:.::....:.:.:.   ::::|.|:...:|..:.:..|...
Mouse   145 -------YDWYQTESHVIITLMIKSVQKNDVRVGFSER---ELSALVKIPAGEDYSLKLRLLHPI 199

  Fly   214 LCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNALSGLKNKPDSKPEKELCTR 278
            :.|.|.               .:||..|.|                   :|.|   |||
Mouse   200 IPEQST---------------FKVLSTKIE-------------------IKMK---KPE------ 221

  Fly   279 NNREIDTLLTCLVYSITDRTISGAARDGVIELITRNV--------HYTALEWAERLVEIRGLCRL 335
                          ::....:.|...:...:..|.:|        |||. .|.:.:.||:
Mouse   222 --------------AVRWEKLEGQGDEPTPKQFTADVKNMYPSSSHYTR-NWDKLVGEIK----- 266

  Fly   336 LDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDEYIKDKLLAPDMES 400
                   |:.|.|.   :.|.::      |.::::.:|        :|..|| :|..:....|||
Mouse   267 -------EEEKNEK---LEGDAA------LNKLFQQIY--------SDGSDE-VKRAMNKSFMES 306

  Fly   401 KVRVTVAITALLNGPLDVGNQVV 423
                  ..|.|.....|||.:.|
Mouse   307 ------GGTVLSTNWSDVGKRKV 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	15/50 (30%)
		TPR repeat	16..41	CDD:276809	4/10 (40%)
		TPR repeat	46..79	CDD:276809	11/32 (34%)
		TPR_11	50..115	CDD:290150	24/72 (33%)
		TPR	50..83	CDD:197478	12/32 (38%)
		UNC45-central	351..494	CDD:288539	16/73 (22%)
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
Sugt1	NP_080750.1	TPR 1	11..44		4/18 (22%)
		PLN03088	21..336	CDD:215568	80/413 (19%)
		Motor_domain	<38..>107	CDD:277568	21/71 (30%)
		TPR repeat	44..74	CDD:276809	11/29 (38%)
		TPR 2	45..78		12/32 (38%)
		TPR	45..78	CDD:197478	12/32 (38%)
		TPR 3	79..112		12/37 (32%)
		TPR repeat	79..107	CDD:276809	9/27 (33%)
		p23_CS_hSgt1_like	146..229	CDD:107239	17/142 (12%)
		SGS	256..336	CDD:282811	22/105 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840