DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-45 and zgc:123010

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_005169572.1	Gene:	zgc:123010 / 641500	ZFINID:	ZDB-GENE-051120-15	Length:	501	Species:	Danio rerio

Alignment Length:	301	Identity:	74/301 - (24%)
Similarity:	116/301 - (38%)	Gaps:	82/301 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTESL 77
            :.|..:||....:..::.:||..:.:|||...|...   |:.||:..|..|.:|..|:.|..:|:
Zfish   211 SASLVEKGIRFVQEGQYTQAVSLFTEAIKCDPKDYR---FFGNRSYCYCCLEQYALALADAEKSI 272

  Fly    78 KAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSARNAKTS 142
            :.||..||..:||..|...|:::.||.|....:.|.| |:             .||  |.|....
Zfish   273 QMAPDWPKGYYRRGSALMGLKRYSEAEKAMEQVLKLD-GD-------------CEE--AVNDLLY 321

  Fly   143 TKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKD------- 200
            .||:|:.:|.:|                    |:...:||.|.:.:..|.:.....:|
Zfish   322 CKVQQLTELGYD--------------------EEQSIQLLEKYNTVQAVVAAKASNQDCALLQPG 366

  Fly   201 --QDIYVNMVHLVAALCENSVERTKGVLTEL----GVPWFMRVLDQKHENCVSTAQFCLQTILNA 259
              ..::|..|         :.|.|:..|.:|    |....:|||   ||      :||      |
Zfish   367 PCNSLWVGNV---------TTELTEKHLRDLFKIYGEIDSIRVL---HE------RFC------A 407

  Fly   260 LSGLKN-KPDSKPEKELCTRNNREIDTLLTCLVYSITDRTI 299
            ....|| ...|:..::|   |...|:.  |.||....||.|
Zfish   408 FVNFKNANMASRAMEKL---NGHFIEN--TRLVVRYPDRRI 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	18/67 (27%)
		TPR repeat	16..41	CDD:276809	5/24 (21%)
		TPR repeat	46..79	CDD:276809	9/32 (28%)
		TPR_11	50..115	CDD:290150	21/64 (33%)
		TPR	50..83	CDD:197478	11/32 (34%)
		UNC45-central	351..494	CDD:288539
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
zgc:123010	XP_005169572.1	TPR_11	214..276	CDD:290150	17/64 (27%)
		TPR repeat	214..239	CDD:276809	5/24 (21%)
		TPR repeat	244..274	CDD:276809	9/32 (28%)
		TPR_11	250..309	CDD:290150	20/58 (34%)
		TPR_2	279..309	CDD:285020	10/29 (34%)
		TPR repeat	279..307	CDD:276809	9/27 (33%)
		TPR_11	282..343	CDD:290150	22/96 (23%)
		TPR repeat	313..343	CDD:276809	12/51 (24%)
		RRM	<364..>438	CDD:223796	24/102 (24%)
		RRM	370..436	CDD:214636	23/94 (24%)
		zf-CCCH	471..492	CDD:279036
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590867
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840