DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-45 and si:dkey-33c12.4

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_021336269.1	Gene:	si:dkey-33c12.4 / 560112	ZFINID:	ZDB-GENE-030131-2527	Length:	648	Species:	Danio rerio

Alignment Length:	185	Identity:	42/185 - (22%)
Similarity:	78/185 - (42%)	Gaps:	33/185 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 INSEEVSDAGSYKDK-------GNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLK 62
            :|.||..:|..:..:       |||...:...|.||:::..|||...|..:|   :.||:..|.|
Zfish   300 VNGEESVNANDFITRSVELAVIGNEYAGSGNMEMAVKYFTDAIKHNPKEYKL---FGNRSYCYEK 361

  Fly    63 LGKYENAVEDCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRL 127
            :.:||.::.|...:|...|...|.|:|:.:|...|:::.||......:.|.|...|.....:.|:
Zfish   362 MLQYEKSLTDAEIALSMNPKWIKGLYRKGRALVGLKRYNEARLTFGEVLKLDSSCKDAAEEIMRV 426

  Fly   128 HVVVEERSARNAKTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELL 182
            .::                |:|::.|       .:..::|.|::....:...|.|
Zfish   427 QLM----------------QLMEMGF-------TKEQSSNALIIHGTVERALESL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	20/75 (27%)
		TPR repeat	16..41	CDD:276809	7/31 (23%)
		TPR repeat	46..79	CDD:276809	9/32 (28%)
		TPR_11	50..115	CDD:290150	17/64 (27%)
		TPR	50..83	CDD:197478	9/32 (28%)
		UNC45-central	351..494	CDD:288539
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
si:dkey-33c12.4	XP_021336269.1	PLN03088	258..>439	CDD:330826	38/164 (23%)
		TPR repeat	348..378	CDD:276809	9/32 (28%)
		TPR repeat	383..411	CDD:276809	7/27 (26%)
		UBA	430..456	CDD:270456	5/32 (16%)
		RRM	<471..>614	CDD:223796
		RRM	519..584	CDD:214636
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930