DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-45 and UNC45A

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001310548.1	Gene:	UNC45A / 55898	HGNCID:	30594	Length:	944	Species:	Homo sapiens

Alignment Length:	942	Identity:	342/942 - (36%)
Similarity:	548/942 - (58%)	Gaps:	38/942 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTE 75
            |.....:.:|||.||...:..|:..|.:|:...:..::.||.::||||.:|||..|:.|..:.::
Human    19 SSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASK 83

  Fly    76 SLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSARNAK 140
            :::...||.|||:||:||.|.|.:.::|..|.......:|.||..|..|:.:...::|:....:.
Human    84 AIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSS 148

  Fly   141 TSTKVKQMMDLTFDLATP----IDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQ 201
            |..||:||..:..|   |    .:|::.|:.||||||:|..|||.:::.:.:..:..|..: .:.
Human   149 TDAKVEQMFQILLD---PEEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDM-GET 209

  Fly   202 DIYVNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNAL-SGLKN 265
            |:.:..:..:..:|.....||...|:.||....:.:|..:.:.....|...||.:.:|| .|:|.
Human   210 DLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACHLLQVMFDALKEGVKK 274

  Fly   266 KPDSKPEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELITRNVHYTALE--------W 322
            ....| |..:.....||:..|::.|:..:|:..:||..||..:.|:.:.|...:|:        |
Human   275 GFRGK-EGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSLTLW 338

  Fly   323 AERLVEIRGLCRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDE 387
                |..:||.::|:|...|:|...|.|  :|.:|...||:.|:::::::..|..:..|....:.
Human   339 ----VIDQGLKKILEVGGSLQDPPGELA--VTANSRMSASILLSKLFDDLKCDAERENFHRLCEN 397

  Fly   388 YIKDKLLAPDMESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLI 452
            |||.......:..|:|....::.||.||.|.||:.:...|:::.::|:..::.|.:|.|:.|.||
Human   398 YIKSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEQEEEQLVAVEALI 462

  Fly   453 AASSKKDKAKALCEQGVDILKRLYH-SKNDGIRVRALVGLCKLGSYGGQDAAIRPFGDGAALKLA 516
            .|:.|..:|..:...||.:||.||. |:.|.||:|||||||||||.||.|.:::.|.:|:.||||
Human   463 HAAGKAKRASFITANGVSLLKDLYKCSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLA 527

  Fly   517 EACRRFLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDLARGGNQSCLYGVVTT 581
            :.||::|.....|...||||.:||||||.||:.||:.:||.|::.||..|:|...:|.|:.|.:.
Human   528 KQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSRLEERSVLFAVASA 592

  Fly   582 FVNLCNAYEKQEMLPEMIELAKFAKQHIPEEHELDDVDFINKRITVLANEGITTALCALAKTES- 645
            .||..|:|:.:|..|:|:||||:||||:||:|..|...|:..|:..|...|:.:|:..:.||||
Human   593 LVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMVCMVKTESP 657

  Fly   646 ---HNSQELIARVLNAVCGLKELRGKVVQEGGVKALLRMALEGTEKGKRHATQALARIGITINPE 707
               .:.:||::||..|:....|.||.||.:||.:||:.:|||||:.|:..|.||||::.||.|||
Human   658 VLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAAQALAKLTITSNPE 722

  Fly   708 VSFSGQRSLDVIRPLLNLLQQDCTALENFESLMALTNLASMNESVRQRIIKEQGVSKIEYYLMED 772
            ::|.|:|..:|:|||::||..:|:.|:|||:||||||||.::|.:||:|:||:.|..||.|:.|:
Human   723 MTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEE 787

  Fly   773 HLYLTRAAAQCLCNLVMSEDVIKMFEG-NNDRVKFLALLCEDEDEETATACAGALAIITSVSVKC 836
            |..:.|||.:|:|||.||::|..:||. .|||:|.|.|...::||....|.||.||::||:....
Human   788 HEMIRRAATECMCNLAMSKEVQDLFEAQGNDRLKLLVLYSGEDDELLQRAAAGGLAMLTSMRPTL 852

  Fly   837 CEKILAIAS-WLDILHTLIANPSPAVQHRGIVIILNMINAGEEIAKKLFETDIMELLSGL--GQL 898
            |.:|..:.: ||:||..|:.:.:..:||||.|::|||:.|..|||..|.|:::||:||.|  |..
Human   853 CSRIPQVTTHWLEILQALLLSSNQELQHRGAVVVLNMVEASREIASTLMESEMMEILSVLAKGDH 917

  Fly   899 PDDTRAKAREVATQCLAAAERYRIIERSDNAE 930
            ...|||     |..||..|..|.:|:.:.:.|
Human   918 SPVTRA-----AAACLDKAVEYGLIQPNQDGE 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	19/68 (28%)
		TPR repeat	16..41	CDD:276809	8/24 (33%)
		TPR repeat	46..79	CDD:276809	11/32 (34%)
		TPR_11	50..115	CDD:290150	24/64 (38%)
		TPR	50..83	CDD:197478	11/32 (34%)
		UNC45-central	351..494	CDD:288539	47/143 (33%)
		ARM	668..788	CDD:237987	62/119 (52%)
		armadillo repeat	753..789	CDD:293788	18/35 (51%)
		armadillo repeat	795..826	CDD:293788	13/31 (42%)
UNC45A	NP_001310548.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		1/1 (100%)
		TPR 1	21..54		8/32 (25%)
		TPR repeat	21..49	CDD:276809	8/27 (30%)
		PLN03088	<23..>144	CDD:330826	38/120 (32%)
		TPR repeat	57..87	CDD:276809	11/29 (38%)
		TPR 2	58..91		11/32 (34%)
		TPR 3	92..125		12/32 (38%)
		TPR repeat	92..120	CDD:276809	11/27 (41%)
		UNC45-central	363..505	CDD:314546	47/141 (33%)
		armadillo repeat	768..803	CDD:293788	17/34 (50%)
		armadillo repeat	806..842	CDD:293788	14/35 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155700
Domainoid	1	1.000	365	1.000	Domainoid score	I934
eggNOG	1	0.900	-	-		E1_KOG4151
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	596	1.000	Inparanoid score	I968
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45249
OrthoDB	1	1.010	-	-		D1059433at2759
OrthoFinder	1	1.000	-	-		FOG0002389
OrthoInspector	1	1.000	-	-		otm42258
orthoMCL	1	0.900	-	-		OOG6_103191
Panther	1	1.100	-	-	LDO	PTHR45994
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3298
SonicParanoid	1	1.000	-	-		X2500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800