DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-45 and TTC12

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_005271661.1	Gene:	TTC12 / 54970	HGNCID:	23700	Length:	777	Species:	Homo sapiens

Alignment Length:	865	Identity:	171/865 - (19%)
Similarity:	272/865 - (31%)	Gaps:	347/865 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTESL 77
            |.:.|:||||||....:|.|:..|.:.::   |.|::.|.|.|||.||:||..||.|:.||..:|
Human   106 ADALKEKGNEAFAEGNYETAILRYSEGLE---KLKDMKVLYTNRAQAYMKLEDYEKALVDCEWAL 167

  Fly    78 KAAPGDPKALFRRAQAYEALEKF---EEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSARNA 139
            |......||.|...:|..||:.:   .|.||....:                           |.
Human   168 KCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEI---------------------------NP 205

  Fly   140 KTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQDIY 204
            |..|:||..:: ..||....|.:...|:.|:...|
Human   206 KLQTQVKGYLN-QVDLQEKADLQEKEAHELLDSGK------------------------------ 239

  Fly   205 VNMVHLVAALCENSVERTKGVLTELG----VPWF----MRVLDQKHENCVSTAQFCLQTILNALS 261
                        |:...||.:|..|.    :|.|    :.:|.:....|..      ||:....:
Human   240 ------------NTAVTTKNLLETLSKPDQIPLFYAGGIEILTEMINECTE------QTLFRMHN 286

  Fly   262 GLKNKPDSKPEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELI------------TRN 314
            |.....|::                       :..|..|.|..|.|.|::            :||
Human   287 GFSIISDNE-----------------------VIRRCFSTAGNDAVEEMVCVSVLKLWQAVCSRN 328

  Fly   315 VHYTALEWAERLVEI-----RGLCRLLDVCSELEDYKYES-------AMDITGSSSTIASVCLAR 367
                  |..:|::.|     |.|..||.  |::...:.:|       |...:|.|..|..:.|.|
Human   329 ------EENQRVLVIHHDRARLLAALLS--SKVLAIRQQSFALLLHLAQTESGRSLIINHLDLTR 385

  Fly   368 IYENMYYDEAKARFTDQIDEYIKDKL-LAPDMESKVRVTVAITALLNGPLDVGNQVVAREGILQM 431
            :.      ||...|.|..|:.....: |..|:..:.|..|...|.|.|.|.      |..|:|:
Human   386 LL------EALVSFLDFSDKEANTAMGLFTDLALEERFQVWFQANLPGVLP------ALTGVLK- 437

  Fly   432 ILAMATTDDELQQRVS-CECL-----IAASSKKDKAKALCEQGVDILKRLYHSKNDGIRVRALVG 490
                  ||.::....: |:|:     ::|.....:..|.||:
Human   438 ------TDPKVSSSSALCQCIAIMGNLSAEPTTRRHMAACEE----------------------- 473

  Fly   491 LCKLGSYGGQDAAIRPFGDGAALKLAEACRRFLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIE 555
                            ||||.                               |:|.|.|:|.
Human   474 ----------------FGDGC-------------------------------LSLLARCEED--- 488

  Fly   556 DKASIHALMDLARGGNQSCLYGVVTTFVNLCNAYEKQEMLPEMIELAKFAKQHIPEEHELDDVDF 620
                    :||.|    ..:|.::...:|||                    ...|...|:..|:
Human   489 --------VDLFR----EVIYTLLGLMMNLC--------------------LQAPFVSEVWAVE- 520

  Fly   621 INKRITVLANE---GITTALCALAKTESHNSQELIARVLNAVCGLKELRGKVVQEGGVKALLRMA 682
            :::|...|.|.   ||.|....:......:|.:::...|.|              |.||.:::..
Human   521 VSRRCLSLLNSQDGGILTRAAGVLSRTLSSSLKIVEEALRA--------------GVVKKMMKFL 571

  Fly   683 LEGTEKGKRHATQALARIGITINPEVSFSGQRSLDVIRPLLNLLQQDCTALENFESLMALTNLAS 747
            ..|.|...|:|.:.||   |..|   |:...|. :|||            |:  :.|..:..|.|
Human   572 KTGGETASRYAIKILA---ICTN---SYHEARE-EVIR------------LD--KKLSVMMKLLS 615

  Fly   748 MNESVRQRIIKEQGVSKIEYYLMEDHLYLTRAAAQCLCNLV----MSEDVIKMFEGNNDRVKFLA 808
            ..:.|                       |...||.||.|.:    ::..::|     .|.::.|.
Human   616 SEDEV-----------------------LVGNAALCLGNCMEVPNVASSLLK-----TDLLQVLL 652

  Fly   809 LLCEDEDEETATACAGALAI 828
            .|...:.::||......:|:
Human   653 KLAGSDTQKTAVQVNAGIAL 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	29/67 (43%)
		TPR repeat	16..41	CDD:276809	10/24 (42%)
		TPR repeat	46..79	CDD:276809	16/32 (50%)
		TPR_11	50..115	CDD:290150	25/67 (37%)
		TPR	50..83	CDD:197478	16/32 (50%)
		UNC45-central	351..494	CDD:288539	29/149 (19%)
		ARM	668..788	CDD:237987	27/119 (23%)
		armadillo repeat	753..789	CDD:293788	6/39 (15%)
		armadillo repeat	795..826	CDD:293788	6/30 (20%)
TTC12	XP_005271661.1	TPR_11	106..171	CDD:290150	29/67 (43%)
		BamD	106..>164	CDD:276939	26/60 (43%)
		TPR repeat	106..138	CDD:276939	12/34 (35%)
		TPR repeat	106..134	CDD:276809	11/27 (41%)
		TPR repeat	139..169	CDD:276809	15/29 (52%)
		TPR_11	142..205	CDD:290150	24/89 (27%)
		TPR_1	143..173	CDD:278916	15/29 (52%)
		TPR repeat	174..202	CDD:276809	9/27 (33%)
		TPR repeat	211..236	CDD:276809	7/25 (28%)
		ARM	526..631	CDD:237987	34/162 (21%)
		armadillo repeat	555..591	CDD:293788	12/52 (23%)
		armadillo repeat	597..631	CDD:293788	14/71 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155694
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840