Protein Alignment unc-45 and TTC12

DIOPT Version :10

• Sequence 1: NP_524796.1
• Gene: unc-45 / 44910
• FlyBaseID: FBgn0288846
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_001305462.1
• Gene: TTC12 / 54970
• HGNCID: 23700
• Length: 711
• Species: Homo sapiens
• Alignment Length: 896
• Identity: 178/896 - (19%)
• Similarity: 281/896 - (31%)
• Gaps: 358/896 - (39%)

  Fly    13 AGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTESL 77
            |.:.|:||||||....:|.|:..|.:.::   |.|::.|.|.|||.||:||..||.|:.||..:|
Human   106 ADALKEKGNEAFAEGNYETAILRYSEGLE---KLKDMKVLYTNRAQAYMKLEDYEKALVDCEWAL 167

  Fly    78 KA------APGDPKALFRRAQAYEALEKF---EEAYKDATALFKADPGNKTVQPMLQRLHVVVEE 133
            |:      .....||.|...:|..||:.:   .|.||....:
Human   168 KSFSFMQCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEI----------------------- 209

  Fly   134 RSARNAKTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVE 198
                |.|..|:||..:: ..||....|.:...|:.|:...|
Human   210 ----NPKLQTQVKGYLN-QVDLQEKADLQEKEAHELLDSGK------------------------ 245

  Fly   199 KDQDIYVNMVHLVAALCENSVERTKGVLTELG----VPWF----MRVLDQKHENCVSTAQFCLQT 255
                              |:...||.:|..|.    :|.|    :.:|.:....|..      ||
Human   246 ------------------NTAVTTKNLLETLSKPDQIPLFYAGGIEILTEMINECTE------QT 286

  Fly   256 ILNALSGLKNKPDSKPEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELI--------- 311
            :....:|.....|::                       :..|..|.|..|.|.|::
Human   287 LFRMHNGFSIISDNE-----------------------VIRRCFSTAGNDAVEEMVCVSVLKLWQ 328

  Fly   312 ---TRNVHYTALEWAERLVEI-----RGLCRLLDVCSELEDYKYES-------AMDITGSSSTIA 361
               :||      |..:|::.|     |.|..||.  |::...:.:|       |...:|.|..|.
Human   329 AVCSRN------EENQRVLVIHHDRARLLAALLS--SKVLAIRQQSFALLLHLAQTESGRSLIIN 385

  Fly   362 SVCLARIYENMYYDEAKARFTDQIDEYIKDKL-LAPDMESKVRVTVAITALLNGPLDVGNQVVAR 425
            .:.|.|:.      ||...|.|..|:.....: |..|:..:.|..|...|.|.|.|.      |.
Human   386 HLDLTRLL------EALVSFLDFSDKEANTAMGLFTDLALEERFQVWFQANLPGVLP------AL 438

  Fly   426 EGILQMILAMATTDDELQQRVS-CECL-----IAASSKKDKAKALCEQGVDILKRLYHSKNDGIR 484
            .|:|:       ||.::....: |:|:     ::|.....:..|.||:
Human   439 TGVLK-------TDPKVSSSSALCQCIAIMGNLSAEPTTRRHMAACEE----------------- 479

  Fly   485 VRALVGLCKLGSYGGQDAAIRPFGDGAALKLAEACRRFLIKPGKDKDIRRWAADGLAYLTLDAEC 549
                                  ||||.                               |:|.|.|
Human   480 ----------------------FGDGC-------------------------------LSLLARC 491

  Fly   550 KEKLIEDKASIHALMDLARGGNQSCLYGVVTTFVNLCNAYEKQEMLPEMIELAKFAKQHIPEEHE 614
            :|.           :||.|    ..:|.::...:|||                    ...|...|
Human   492 EED-----------VDLFR----EVIYTLLGLMMNLC--------------------LQAPFVSE 521

  Fly   615 LDDVDFINKRITVLANE---GITTALCALAKTESHNSQELIARVLNAVCGLKELRGKVVQEGGVK 676
            :..|: :::|...|.|.   ||.|....:......:|.:::...|.|              |.||
Human   522 VWAVE-VSRRCLSLLNSQDGGILTRAAGVLSRTLSSSLKIVEEALRA--------------GVVK 571

  Fly   677 ALLRMALEGTEKGKRHATQALARIGITINPEVSFSGQRSLDVIRPLLNLLQQDCTALENFESLMA 741
            .:::....|.|...|:|.:.||   |..|   |:...|. :|||            |:  :.|..
Human   572 KMMKFLKTGGETASRYAIKILA---ICTN---SYHEARE-EVIR------------LD--KKLSV 615

  Fly   742 LTNLASMNESVRQRIIKEQGVSKIEYYLMEDHLYLTRAAAQCLCNLV----MSEDVIKMFEGNND 802
            :..|.|..:.|                       |...||.||.|.:    ::..::|     .|
Human   616 MMKLLSSEDEV-----------------------LVGNAALCLGNCMEVPNVASSLLK-----TD 652

  Fly   803 RVKFLALLCEDEDEETATACAGALAIITSVSVKCCEKILAIASWLDILHTL 853
            .::.|..|...:.::||......:|:     .|.|......|:.|..||.|
Human   653 LLQVLLKLAGSDTQKTAVQVNAGIAL-----GKLCTAEPRFAAQLRKLHGL 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_524796.1	3a0801s09	7..>127	CDD:273380	38/122 (31%)
		TPR repeat	16..41	CDD:276809	10/24 (42%)
		TPR repeat	46..79	CDD:276809	16/32 (50%)
		UNC45-central	351..494	CDD:432011	29/149 (19%)
		PLN03200	399..>700	CDD:215629	54/309 (17%)
		armadillo repeat	753..789	CDD:293788	6/39 (15%)
		armadillo repeat	795..826	CDD:293788	6/30 (20%)
TTC12	NP_001305462.1	TPR	105..>212	CDD:440225	39/135 (29%)
		TPR 1	106..139		13/35 (37%)
		TPR repeat	106..134	CDD:276809	11/27 (41%)
		TPR repeat	139..175	CDD:276809	16/35 (46%)
		TPR 3	180..213		10/59 (17%)
		TPR repeat	180..208	CDD:276809	9/27 (33%)
		TPR repeat	217..242	CDD:276809	7/25 (28%)
		armadillo repeat	561..597	CDD:293788	12/52 (23%)
		armadillo repeat	603..637	CDD:293788	14/71 (20%)