DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-45 and Sgta

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001345478.1	Gene:	Sgta / 52551	MGIID:	1098703	Length:	315	Species:	Mus musculus

Alignment Length:	206	Identity:	64/206 - (31%)
Similarity:	88/206 - (42%)	Gaps:	41/206 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NSEEVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAV 70
            :.|:.::|...|.:|||..|...:|.||..|||||:....:   ||::.||||||.|||.|..||
Mouse    85 SEEDSAEAERLKTEGNEQMKLENFEAAVHLYGKAIELNPAN---AVYFCNRAAAYSKLGNYVGAV 146

  Fly    71 EDCTESLKAAPGDPKALFRRAQAYEALEKFEEA---YKDATALFKADPGNKTVQPMLQRLHVVVE 132
            :||..::...||..||..|...|..:|.|..||   ||.|..|   ||.|.|.:..|:     :.
Mouse   147 QDCERAIGIDPGYSKAYGRMGLALSSLNKHAEAVAYYKKALEL---DPDNDTYKSNLK-----IA 203

  Fly   133 ERSARNAKTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKV 197
            |...|.|.:.|.....:|:                           |.||...|.|...:||...
Mouse   204 ELKLREAPSPTGGVGSLDI---------------------------AGLLNNPHFITMASSLMNS 241

  Fly   198 EKDQDIYVNMV 208
            .:.|.:...|:
Mouse   242 PQLQQLMSGMI 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	30/68 (44%)
		TPR repeat	16..41	CDD:276809	12/24 (50%)
		TPR repeat	46..79	CDD:276809	16/32 (50%)
		TPR_11	50..115	CDD:290150	30/67 (45%)
		TPR	50..83	CDD:197478	17/32 (53%)
		UNC45-central	351..494	CDD:288539
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
Sgta	NP_001345478.1	SGTA_dimer	5..64	CDD:318697
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..100		3/14 (21%)
		TPR 1	92..125		14/32 (44%)
		TPR repeat	92..120	CDD:276809	13/27 (48%)
		PLN03088	106..>212	CDD:330826	46/116 (40%)
		TPR repeat	125..155	CDD:276809	16/32 (50%)
		TPR 2	126..159		17/32 (53%)
		TPR 3	160..193		14/35 (40%)
		TPR repeat	160..188	CDD:276809	11/27 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..270		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846130
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840