DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-45 and sgtb

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001002225.2	Gene:	sgtb / 431772	ZFINID:	ZDB-GENE-040704-72	Length:	320	Species:	Danio rerio

Alignment Length:	153	Identity:	47/153 - (30%)
Similarity:	75/153 - (49%)	Gaps:	12/153 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EEVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVED 72
            |::..|...|::||...|...:..||:.|.|||:...::   ||:|.|||||:.||..|..|:.|
Zfish    96 EDIERAEQLKNEGNNHMKEENYSSAVDCYTKAIELDQRN---AVYYCNRAAAHSKLENYTEAMGD 157

  Fly    73 CTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSAR 137
            |..::...|...||..|...|..::.|:.||..........||.|.|.:   ..|.:|.:::...
Zfish   158 CERAIAIDPSYSKAYGRMGLALTSMSKYPEAISYFNKALVLDPENDTYK---SNLKIVEQKQKEA 219

  Fly   138 NAKTSTKVKQMMDLTFDLATPID 160
            ::.|:|      .|.||:|:.|:
Zfish   220 SSPTAT------GLGFDMASLIN 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	25/68 (37%)
		TPR repeat	16..41	CDD:276809	9/24 (38%)
		TPR repeat	46..79	CDD:276809	14/32 (44%)
		TPR_11	50..115	CDD:290150	22/64 (34%)
		TPR	50..83	CDD:197478	15/32 (47%)
		UNC45-central	351..494	CDD:288539
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
sgtb	NP_001002225.2	TPR_11	134..200	CDD:290150	22/68 (32%)
		TPR repeat	134..164	CDD:276809	14/32 (44%)
		TPR_1	135..168	CDD:278916	15/32 (47%)
		TPR_1	169..202	CDD:278916	9/32 (28%)
		TPR repeat	169..196	CDD:276809	7/26 (27%)
		SGTA_dimer	20..76	CDD:293154
		TPR_11	100..166	CDD:290150	25/68 (37%)
		TPR	101..134	CDD:197478	11/32 (34%)
		TPR repeat	101..129	CDD:276809	10/27 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840