DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-45 and Sgt

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001246058.1	Gene:	Sgt / 35052	FlyBaseID:	FBgn0032640	Length:	331	Species:	Drosophila melanogaster

Alignment Length:	271	Identity:	70/271 - (25%)
Similarity:	109/271 - (40%)	Gaps:	73/271 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NSEEVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAV 70
            |.|.::.|.|.|::||...|.:::.||:..|.:||....|:   .:||.|||||:::||:.|.||
  Fly   109 NPESLALAESIKNEGNRLMKENKYNEALLQYNRAIAFDPKN---PIFYCNRAAAHIRLGENERAV 170

  Fly    71 EDCTESLKAAPGDPKALFRRAQAYEAL---EKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVE 132
            .||..:|.......||..|...||..:   ||.|:||..|..|   :|.|:..:..|:
  Fly   171 TDCKSALVYNNNYSKAYCRLGVAYSNMGNFEKAEQAYAKAIEL---EPDNEVYKSNLE------- 225

  Fly   133 ERSARNAKTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKV 197
              :||||:..                               ..|||                 ::
  Fly   226 --AARNARNQ-------------------------------PPQTG-----------------RL 240

  Fly   198 EKDQDIYVNMVH--LVAALCENSVERTKGVLTELGVPWFMRVLDQKH--ENCVSTAQFCLQTILN 258
            .:|   .:||:.  :|..|..|:....:.:|:.|..|..|..:.|:.  .|..:.....:|.|.|
  Fly   241 RED---LINMLSQPMVRNLFNNAEIDVEQLLSMLQNPMIMNTIRQQFGGGNAPTLPNDMVQMIYN 302

  Fly   259 ALSGLKNKPDS 269
            ..|.|...|:|
  Fly   303 MTSQLTGFPNS 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	27/68 (40%)
		TPR repeat	16..41	CDD:276809	8/24 (33%)
		TPR repeat	46..79	CDD:276809	15/32 (47%)
		TPR_11	50..115	CDD:290150	27/67 (40%)
		TPR	50..83	CDD:197478	15/32 (47%)
		UNC45-central	351..494	CDD:288539
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
Sgt	NP_001246058.1	SGTA_dimer	9..>48	CDD:293154
		TPR_11	116..177	CDD:290150	26/63 (41%)
		TPR_2	116..149	CDD:285020	11/32 (34%)
		TPR repeat	116..144	CDD:276809	10/27 (37%)
		TPR_17	139..170	CDD:290167	14/33 (42%)
		TPR repeat	149..179	CDD:276809	15/32 (47%)
		TPR_16	156..218	CDD:290168	25/64 (39%)
		TPR_1	184..217	CDD:278916	13/35 (37%)
		TPR repeat	184..212	CDD:276809	11/27 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840