DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-45 and HIP-R

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001014719.2	Gene:	HIP-R / 31335	FlyBaseID:	FBgn0029676	Length:	377	Species:	Drosophila melanogaster

Alignment Length:	178	Identity:	50/178 - (28%)
Similarity:	77/178 - (43%)	Gaps:	34/178 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EEVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVED 72
            |||..|...:.:...|:...:::||:..|.|||:....:   |:|:..|..|:|||.|....:.|
  Fly   121 EEVEQASELRAQAASAYGQQKFDEAIALYTKAIELSPGN---ALFHAKRGQAFLKLKKPNACIRD 182

  Fly    73 CTESLKAAPGDPKALFR-RAQAYEALEKFEEAYKDATALFKADPGNKT------VQPMLQRL--H 128
            |..:|: ...|..|.:: |.:|...|..||.|..|.....|.|...:|      |.|..:::  |
  Fly   183 CDVALE-LNSDLAAGYKFRGRARRLLGDFELAAHDLRQACKLDFDEETDEWLKEVTPNAKKIEQH 246

  Fly   129 VVVEERSARNAKTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQ 176
            .:.:||  |.|:...|.:|.           |:|||        .|||
  Fly   247 RLKQER--RQAERKIKERQR-----------DQRRA--------RKEQ 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	19/68 (28%)
		TPR repeat	16..41	CDD:276809	6/24 (25%)
		TPR repeat	46..79	CDD:276809	11/32 (34%)
		TPR_11	50..115	CDD:290150	21/65 (32%)
		TPR	50..83	CDD:197478	11/32 (34%)
		UNC45-central	351..494	CDD:288539
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
HIP-R	NP_001014719.2	Hip_N	10..47	CDD:271228
		TPR_11	125..190	CDD:290150	19/68 (28%)
		TPR_2	126..159	CDD:285020	8/32 (25%)
		TPR repeat	126..154	CDD:276809	7/27 (26%)
		TPR repeat	159..189	CDD:276809	11/33 (33%)
		TPR repeat	194..222	CDD:276809	8/27 (30%)
		STI1	299..336	CDD:128966
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462453
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840