DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-45 and Unc45a

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001032736.1	Gene:	Unc45a / 308759	RGDID:	1305357	Length:	944	Species:	Rattus norvegicus

Alignment Length:	942	Identity:	342/942 - (36%)
Similarity:	554/942 - (58%)	Gaps:	38/942 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTE 75
            |.|...:.:|||.||...:|.|:..|.:|:..|:..::.|:.::||||.:|||..|..|..:.::
  Rat    19 SSAEELRKEGNELFKCGDYEGALTAYTQALSLGATPQDQAILHRNRAACHLKLEDYSKAESEASK 83

  Fly    76 SLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSARNAK 140
            :::...||.|||:||:||.|.|.:.::|..|.......:|.||..|..|:.:...::|:....:.
  Rat    84 AIEKDGGDVKALYRRSQALEKLGRLDQAVLDLKRCVSLEPKNKVFQESLRNIGGQIQEKVRYMSS 148

  Fly   141 TSTKVKQMMDLTFDLATP----IDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQ 201
            |..||:||..:..|   |    .:|::.|:.||||||:|..|||.:::.:.:..:..|... .:.
  Rat   149 TDAKVEQMFQILLD---PKEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDT-GET 209

  Fly   202 DIYVNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNAL-SGLKN 265
            |:.:..:..:..:|.....||...|:.||....:.:|..:::.....|...||.:.:|| .|:|.
  Rat   210 DLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSILGVENQAVSLAACHLLQVMFDALKEGVKK 274

  Fly   266 KPDSKPEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELITRNV--------HYTALEW 322
            ....| |..:.....||:..|::.|:..:|:..:||..||..:.|:.:.|        :.:...|
  Rat   275 GFRGK-EGAIIVDPARELKVLISNLLELLTEIGVSGQGRDNALTLLIKMVPRKSPKDPNNSLTLW 338

  Fly   323 AERLVEIRGLCRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDE 387
                |..:||.::|:|...:.:...|  :.:|.:|...||:.|:::::::..|..:..|....:.
  Rat   339 ----VIDQGLKKILEVGGSVPEAAGE--LTVTANSRMSASILLSKLFDDLKCDAERENFHRLCEN 397

  Fly   388 YIKDKLLAPDMESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLI 452
            ||:.......:..|:|....::.||.||.|.||:.:...|:::.::|:..::.|.:|.|:.|.||
  Rat   398 YIRSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEQEEEQLVAVEALI 462

  Fly   453 AASSKKDKAKALCEQGVDILKRLYH-SKNDGIRVRALVGLCKLGSYGGQDAAIRPFGDGAALKLA 516
            .|:.|..:|..:...||.:||.||. |:.|.||:|||||||||||.||.|.:::.|.:|:.||||
  Rat   463 HAAGKAKRASFITANGVALLKDLYKGSERDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLA 527

  Fly   517 EACRRFLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDLARGGNQSCLYGVVTT 581
            :.||::|.....|...||||.:||||||.||:.||:.:||:|::.||..|:|...:|.|:.|.:.
  Rat   528 KQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDEAALKALFQLSRSEERSVLFAVGSA 592

  Fly   582 FVNLCNAYEKQEMLPEMIELAKFAKQHIPEEHELDDVDFINKRITVLANEGITTALCALAKTES- 645
            .||..|:|:.:|..|:|:||||:||||:||:|..|...|:..|:..|...|:.:|:..:.||||
  Rat   593 LVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMTCMVKTESP 657

  Fly   646 ---HNSQELIARVLNAVCGLKELRGKVVQEGGVKALLRMALEGTEKGKRHATQALARIGITINPE 707
               ::.:||::||..|:....|.||.||.:||.||||.:|||||:.|:..|.||||::.||.|||
  Rat   658 VLTNSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSNPE 722

  Fly   708 VSFSGQRSLDVIRPLLNLLQQDCTALENFESLMALTNLASMNESVRQRIIKEQGVSKIEYYLMED 772
            ::|.|:|..:|:|||::||...|:.|:|||:||||||||.::|.:||:|:||:.|..||.|:.|:
  Rat   723 MTFPGERIYEVVRPLVSLLHLSCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEE 787

  Fly   773 HLYLTRAAAQCLCNLVMSEDVIKMFEG-NNDRVKFLALLCEDEDEETATACAGALAIITSVSVKC 836
            |..:.|||.:|:|||.||::|..:||. .|||:|.|.|...::||....|.||.||::||:....
  Rat   788 HEMIRRAATECMCNLAMSKEVQDLFEAQGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPSL 852

  Fly   837 CEKILAIAS-WLDILHTLIANPSPAVQHRGIVIILNMINAGEEIAKKLFETDIMELLSGL--GQL 898
            |.:|..:.: ||:||..|:.:|:|.:||||.|::|||:.:.:|||..|.|::::|:||.|  |:.
  Rat   853 CSRIPQVTTHWLEILQALLLSPNPELQHRGTVVVLNMMESSKEIASTLMESEVLEILSVLAKGEE 917

  Fly   899 PDDTRAKAREVATQCLAAAERYRIIERSDNAE 930
            ...|||     |..||..|..||:|:.:.:.|
  Rat   918 SPVTRA-----AAACLEKAVEYRLIQPNQDGE 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	21/68 (31%)
		TPR repeat	16..41	CDD:276809	9/24 (38%)
		TPR repeat	46..79	CDD:276809	10/32 (31%)
		TPR_11	50..115	CDD:290150	23/64 (36%)
		TPR	50..83	CDD:197478	10/32 (31%)
		UNC45-central	351..494	CDD:288539	46/143 (32%)
		ARM	668..788	CDD:237987	64/119 (54%)
		armadillo repeat	753..789	CDD:293788	18/35 (51%)
		armadillo repeat	795..826	CDD:293788	13/31 (42%)
Unc45a	NP_001032736.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		2/5 (40%)
		TPR_11	20..88	CDD:290150	21/67 (31%)
		TPR 1	21..54		11/32 (34%)
		TPR repeat	21..49	CDD:276809	10/27 (37%)
		TPR_11	57..123	CDD:290150	23/65 (35%)
		TPR repeat	57..87	CDD:276809	10/29 (34%)
		TPR 2	58..91		10/32 (31%)
		TPR 3	92..125		12/32 (38%)
		TPR_1	92..125	CDD:278916	12/32 (38%)
		TPR repeat	92..120	CDD:276809	11/27 (41%)
		UNC45-central	361..505	CDD:288539	46/143 (32%)
		ARM	684..803	CDD:237987	64/118 (54%)
		armadillo repeat	768..803	CDD:293788	17/34 (50%)
		ARM	769..891	CDD:237987	54/121 (45%)
		armadillo repeat	806..842	CDD:293788	14/35 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349604
Domainoid	1	1.000	376	1.000	Domainoid score	I826
eggNOG	1	0.900	-	-		E1_KOG4151
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	599	1.000	Inparanoid score	I917
OMA	1	1.010	-	-		QHG45249
OrthoDB	1	1.010	-	-		D1059433at2759
OrthoFinder	1	1.000	-	-		FOG0002389
OrthoInspector	1	1.000	-	-		otm46412
orthoMCL	1	0.900	-	-		OOG6_103191
Panther	1	1.100	-	-	LDO	PTHR45994
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770