DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-45 and Unc45b

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_006247058.1	Gene:	Unc45b / 303373	RGDID:	1305666	Length:	929	Species:	Rattus norvegicus

Alignment Length:	926	Identity:	322/926 - (34%)
Similarity:	549/926 - (59%)	Gaps:	15/926 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTE 75
            ::|...|::||:.|:...::.|.:.|.:|:|.......||..|:||||..||:..|..|..|.:.
  Rat     4 AEATQLKEEGNQHFQRQDYKAATKSYSQALKLTKDKALLATLYRNRAACGLKMESYAQAASDASR 68

  Fly    76 SLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSARNAK 140
            ::.....|.|||:||.||.|.|.|.::|:||.......:|.|:..|..|:||:..::|:......
  Rat    69 AIDINSADIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQETLRRLNTSIQEQLRVQFS 133

  Fly   141 TSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQDIYV 205
            |.::|:.|.::..:..:..|||..|||||:||.:|:.|||.:::.:.:|.:..|... |..::.:
  Rat   134 TDSRVQTMFEILLNENSEADKREKAANNLIVLGREEAGAERIFQSNGVALLLQLMDA-KRPELVL 197

  Fly   206 NMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNALSGLKNKPDSK 270
            ..|..::.:|.....|...:|..:.:.....::..::|.........||.|:::|||...:....
  Rat   198 AAVRTLSGMCSGHRARATAILHAVRIDRICSLMALENEEMSLAVCSLLQAIIDSLSGEDKREHRG 262

  Fly   271 PEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELITRNVHYTALEWAE--RLVEI--RG 331
            .|:.|.....:::..:.:.|:..:..:.:||..||..:.|:.:||....|...:  |.:.:  .|
  Rat   263 KEEALVLDTKKDLKQITSHLLDMLVSKKVSGQGRDQALNLLNKNVPRKDLSIHDNSRTIYVVDNG 327

  Fly   332 LCRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDEYIKDKLLAP 396
            |.::|.|..::.|  ..|.:.:|.::..:||:.:.::||::..|..:..|....:|||..|....
  Rat   328 LRKVLKVVGQVPD--LPSCLPLTDNTRMLASILINKLYEDLRCDPERDHFRKICEEYITSKFDPQ 390

  Fly   397 DMESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLIAASSKKDKA 461
            ||:..|.....::.:|.||.|:|||::..:|:::|::|:..::.|..|.|:.|.||.||:|..:|
  Rat   391 DMDKNVNAIQTVSGILQGPFDLGNQLLGMKGVMEMMVALCGSEREADQLVAVEALIHASTKLSRA 455

  Fly   462 KALCEQGVDILKRLYH-SKNDGIRVRALVGLCKLGSYGGQDAAIRPFGDGAALKLAEACRRFLIK 525
            ..:...||.:||::|. :||:.|::|.|||||||||.||.|..:|.|.:|:..|||:.||::|..
  Rat   456 TFIITNGVTLLKQIYKTTKNEKIKIRTLVGLCKLGSAGGSDYGLRQFAEGSTEKLAKQCRKWLCN 520

  Fly   526 PGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDLARGGNQSCLYGVVTTFVNLCNAYE 590
            ...|...||||.:|||||||||:.|:..::|..::.|:.:||:..:::.||.|..|.||..|:|:
  Rat   521 TAIDTRTRRWAVEGLAYLTLDADVKDDFVQDIPALQAMFELAKTSDKTILYSVANTLVNCTNSYD 585

  Fly   591 KQEMLPEMIELAKFAKQHIPEEHELDDVDFINKRITVLANEGITTALCALAKTES----HNSQEL 651
            .:|::||:::||||:|||:||||..|..||::.|:..|...|:.:||..:.|.:|    ..::||
  Rat   586 VKEVVPELVQLAKFSKQHVPEEHPKDKKDFVDLRVKRLLKAGVISALACMVKADSAILTDQTKEL 650

  Fly   652 IARVLNAVCGLKELRGKVVQEGGVKALLRMALEGTEKGKRHATQALARIGITINPEVSFSGQRSL 716
            :|||..|:|...:.||.:|.:||.|||:.:|||||:.||..|...||:|....||:::|.|:|..
  Rat   651 LARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHGLAKIAAVSNPDIAFPGERVY 715

  Fly   717 DVIRPLLNLLQQDCTALENFESLMALTNLASMNESVRQRIIKEQGVSKIEYYLMEDHLYLTRAAA 781
            :|:|||::||......|:|:|:|:.||||:..::.:||:|.||:.:..||.|:.|:|..|.:||.
  Rat   716 EVVRPLVSLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKEKALPDIENYMFENHDQLRQAAT 780

  Fly   782 QCLCNLVMSEDVIKMF-EGNNDRVKFLALLCEDEDEETATACAGALAIITSVSVKCCEKILAIAS 845
            :|:||:|::::|.:.| ...|||:|.:.|||.::|.:...|.|||||::|:...|.|.|:..:.:
  Rat   781 ECMCNMVLNKEVQERFLADGNDRLKLVVLLCGEDDHKLQNAAAGALAMLTAAHKKLCLKMTEVTT 845

  Fly   846 -WLDILHTLIANPSPAVQHRGIVIILNMINAGEEIAKKLFETDIMELLSGLG-QLPDDTRAKARE 908
             ||:||..|..:...:|||||:||..|:::|..|:|:||.||:::|:|:.:| |.||:|||...:
  Rat   846 QWLEILQRLCLHDQLSVQHRGLVIAYNLLSADAELARKLVETELLEILTVVGKQEPDETRAAVVQ 910

  Fly   909 VATQCLAAAERYRIIE 924
            .|.:||.....|..|:
  Rat   911 TARECLIKCMDYGFIK 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	21/68 (31%)
		TPR repeat	16..41	CDD:276809	7/24 (29%)
		TPR repeat	46..79	CDD:276809	12/32 (38%)
		TPR_11	50..115	CDD:290150	25/64 (39%)
		TPR	50..83	CDD:197478	11/32 (34%)
		UNC45-central	351..494	CDD:288539	48/143 (34%)
		ARM	668..788	CDD:237987	52/119 (44%)
		armadillo repeat	753..789	CDD:293788	16/35 (46%)
		armadillo repeat	795..826	CDD:293788	12/31 (39%)
Unc45b	XP_006247058.1	3a0801s09	3..>120	CDD:273380	39/115 (34%)
		TPR repeat	6..34	CDD:276809	8/27 (30%)
		TPR repeat	39..72	CDD:276809	12/32 (38%)
		TPR repeat	77..103	CDD:276809	13/25 (52%)
		UNC45-central	344..489	CDD:403029	48/144 (33%)
		armadillo repeat	752..786	CDD:293788	15/33 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349597
Domainoid	1	1.000	376	1.000	Domainoid score	I826
eggNOG	1	0.900	-	-		E1_KOG4151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14666
Inparanoid	1	1.050	599	1.000	Inparanoid score	I917
OMA	1	1.010	-	-		QHG45249
OrthoDB	1	1.010	-	-		D1059433at2759
OrthoFinder	1	1.000	-	-		FOG0002389
OrthoInspector	1	1.000	-	-		otm46412
orthoMCL	1	0.900	-	-		OOG6_103191
Panther	1	1.100	-	-	O	PTHR45994
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2500
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810