Protein Alignment unc-45 and Ttc12

DIOPT Version :10

• Sequence 1: NP_524796.1
• Gene: unc-45 / 44910
• FlyBaseID: FBgn0288846
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_006243066.1
• Gene: Ttc12 / 300696
• RGDID: 1303264
• Length: 723
• Species: Rattus norvegicus
• Alignment Length: 889
• Identity: 175/889 - (19%)
• Similarity: 287/889 - (32%)
• Gaps: 354/889 - (39%)

  Fly    13 AGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTESL 77
            |.:.|:||||||....:|.|:..|.:.:   .|.|::.|.|.|||.||:|||.|:.|:.||..:|
  Rat   124 ADALKEKGNEAFVKGDYETAIFFYSEGL---GKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWAL 185

  Fly    78 KAAPGDPKALFRRAQAYEALE---KFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSARNA 139
            |......||.|...:|:.||:   |.:|.|                    |::..:       |.
  Rat   186 KCDENCTKAYFHMGKAHLALKNYSKSKECY--------------------QKIGEI-------NP 223

  Fly   140 KTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQDIY 204
            |...:||:.:                  |.|.|.::   |:|..|           |..:..|
  Rat   224 KLKAQVKEHL------------------NQVTLREK---ADLQEK-----------KARESLD-- 254

  Fly   205 VNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNALSGLKNKPDS 269
                     ..:|:...|:.:|..|..|.                    ||.|....|::
  Rat   255 ---------SGKNTAMTTRNLLETLSKPG--------------------QTPLFYAGGIE----- 285

  Fly   270 KPEKELCTRNNREIDTLLTCLVYSITDRTI----SGAARDGVIELITRNVHYTALEWAERLVEIR 330
                            :||.::...|:||:    .|.:.....|:|.|.:.....:..|.:|.:.
  Rat   286 ----------------ILTEMMTDCTERTLFRTYGGFSIINDHEVIKRCLFLAGKDAVEEIVCVS 334

  Fly   331 GLCRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDEYIKDKLLA 395
            .|....:||.:.|:           :...:.|          :.|.|              |||.
  Rat   335 VLKLWQEVCIDNEE-----------NQRLLLS----------HPDMA--------------KLLP 364

  Fly   396 PDMESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMATTDDELQQRVS-------CECLIA 453
            ..|:|::                   :|.::..|.::|.:..||:...|.:.       ||.|::
  Rat   365 SFMDSRI-------------------LVIQQQSLALLLQLTQTDNGRNQVIKHLDMTRLCEALLS 410

  Fly   454 ASSKKDKAKALCEQGV-------------------DILKRLYHSKNDGIRVRALVGLCK----LG 495
            .....|| ||....|:                   |:|..|..:.....::.:...||:    :|
  Rat   411 FLDFSDK-KANTAIGLFTDLALEERFQVWFHANLPDVLPALTGALKREPKLTSPSALCQCIALMG 474

  Fly   496 SYGGQDAAIR------PFGDGAALKLAEACRRFLIKPGKDKDIRRWAADGLAYLTLDAECKEKLI 554
            :...:..|.|      .|||        ||...|:|                       |:|.
  Rat   475 NISAEPTARRHMLAYEEFGD--------ACLDLLVK-----------------------CEED-- 506

  Fly   555 EDKASIHALMDLARGGNQSCLYGVVTTFVNLCNAYEKQEMLPEMIELAKFAKQHIPEEHELDDVD 619
                     |||.|    ...|.::...:|||                    ..:|...|...:.
  Rat   507 ---------MDLYR----EVTYTLLGLIMNLC--------------------LEVPFLSESWAMK 538

  Fly   620 FINKRITVLANEG---ITTALCALAKTESHNSQELIARVLNAVCGLKELRGKVVQEGGVKALLRM 681
            ...|.:::|.::.   :|.|...|::|.| :||.::...|.|              |.||.:::.
  Rat   539 ISRKCLSLLNSQDGGILTRAAGVLSRTLS-SSQTIVEEALTA--------------GVVKKMIKF 588

  Fly   682 ALEGTEKGKRHATQALARIGITINPEVSFSGQRSLDVIRPLLNLLQQDCTALENFESLMALTNLA 746
            ...|.....|:|.:.||   :..|   |:...|.        .:::.|    :.|..||.|  ||
  Rat   589 LKTGGPTASRYAMKTLA---VCTN---SYHAARE--------EVMRLD----KKFNVLMTL--LA 633

  Fly   747 SMNESVRQRIIKEQGVSKIEYYLMEDHLYLTRAAAQCLCNLV----MSEDVIKMFEGNNDRVKFL 807
            |.:|.|                        ...||.||.|.:    .:..::|     .|.::.|
  Rat   634 SEDEVV------------------------VGNAALCLGNCMEVPSAASSLLK-----TDIMRVL 669

  Fly   808 ALLCEDEDEETATACAGALAIITSVSVKCCEKILAIASWLDILH 851
            ..|...:.:|||......:|:     .|.|......|..|..||
  Rat   670 LKLAGGDSQETAVQLNAGIAL-----GKLCTAEPRFAVQLQELH 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_524796.1	3a0801s09	7..>127	CDD:273380	39/116 (34%)
		TPR repeat	16..41	CDD:276809	10/24 (42%)
		TPR repeat	46..79	CDD:276809	16/32 (50%)
		UNC45-central	351..494	CDD:432011	27/172 (16%)
		PLN03200	399..>700	CDD:215629	61/339 (18%)
		armadillo repeat	753..789	CDD:293788	5/39 (13%)
		armadillo repeat	795..826	CDD:293788	7/30 (23%)
Ttc12	XP_006243066.1	TPR	123..>224	CDD:440225	40/129 (31%)
		TPR repeat	124..152	CDD:276809	11/30 (37%)
		TPR repeat	157..187	CDD:276809	15/29 (52%)
		TPR repeat	192..217	CDD:276809	9/44 (20%)