DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-45 and Spata16

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_038959529.1	Gene:	Spata16 / 294932	RGDID:	1563726	Length:	580	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	95/514 - (18%)
Similarity:	171/514 - (33%)	Gaps:	174/514 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VSDAGS-YKDKGNEAFKASRWEEAVEHYGKAIKAG---SKHKE----LAVFYKNR-AAAYLKLGK 65
            :.||.| |:.| ..|..|.::..|:|...|....|   ..|.|    :|.|.:.: ...||::.|
  Rat   181 LKDASSCYRQK-KYAVAAGQFRTALELCSKGAALGKPFEAHAEDIASVASFIETKLVTCYLRMRK 244

  Fly    66 YENAVEDCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVV 130
            .:.|:.....|:...|...:...|:|..:..||::.||
  Rat   245 PDLALNHAHRSIVLNPAYFRNHLRQAAVFRCLERYSEA--------------------------- 282

  Fly   131 VEERSARNAKTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASL- 194
                 ||:|       .:.|..|.|.                    .|:|     ||::|:..|
  Rat   283 -----ARSA-------MIADYMFWLC--------------------GGSE-----HCVSKLIKLY 310

  Fly   195 ---------TKVEKDQDIYVNMVHLVAALCENSVERTKGVLTELGVPWF---------MRVLDQK 241
                     |:.|....:|......:.|   :.:|:.|.|.|:....:.         ..||.|.
  Rat   311 WQAMIEEAITRAEAFSVMYTPFATKIRA---DKIEKVKEVFTKTHPAYVECIYTDTQGFHVLPQT 372

  Fly   242 HE-NCVSTAQFCLQTILNALSGLKNKPDSKPEKELCTRNNREIDT-------------------- 285
            .: :|....|:.|..      |.|||.|.|..:::   :||::.|
  Rat   373 ADWSCFPPQQYLLTL------GFKNKEDGKFLEKV---SNRKLPTFTEHKTPFSPLTREDTVRHM 428

  Fly   286 ------LLTCLVYSITDRTISG--AARDGVIELITRNVHYTALEWAERLVEIRGLCRLLD-VCSE 341
                  :|..|.: |....::|  .|..||:|    .:||.:|  ..||..::...:::: ..:|
  Rat   429 EMVGKRILPILDF-IRSTQLNGNFHACSGVME----KLHYASL--LSRLQRVKEQAQVINQAMAE 486

  Fly   342 LEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDEYIKDKLLAPDMESKVRVTV 406
            |....|  ..||:...:.:....:|..     .|..:.|..|      |:::.....:....:..
  Rat   487 LATVPY--LQDISQQEAELLQSLMADA-----MDTLEGRKND------KERVWNTIQKVSFYLVP 538

  Fly   407 AITALLNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLIAASSKKDKAKALC 465
            |.|.:        ..::.|:..:|....:.|.|           :.:.|.::.:||..|
  Rat   539 AFTCM--------TDILQRKAWMQSRRQLVTLD-----------ISSGSREQREAKPQC 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	20/77 (26%)
		TPR repeat	16..41	CDD:276809	7/24 (29%)
		TPR repeat	46..79	CDD:276809	9/37 (24%)
		TPR_11	50..115	CDD:290150	14/65 (22%)
		TPR	50..83	CDD:197478	8/33 (24%)
		UNC45-central	351..494	CDD:288539	17/115 (15%)
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
Spata16	XP_038959529.1	NYD-SP12_N	5..558	CDD:373477	89/481 (19%)
Spata16	XP_038959529.1	TPR repeat	210..258	CDD:276809	10/47 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349606
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930