DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-45 and Sgtb

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_853660.1	Gene:	Sgtb / 294708	RGDID:	727976	Length:	304	Species:	Rattus norvegicus

Alignment Length:	160	Identity:	51/160 - (31%)
Similarity:	79/160 - (49%)	Gaps:	13/160 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTNTINSEEVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGK 65
            ::|:: .|:|..|...||:||...|...:..||:.|.:||:....:   ||:|.|||||..||..
  Rat    74 LSNSV-PEDVGKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNN---AVYYCNRAAAQSKLSH 134

  Fly    66 YENAVEDCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVV 130
            |.:|::||.:::.......||..|...|..|:.|||||..........||.|.:.:..|:
  Rat   135 YTDAIKDCEKAIAIDSKYSKAYGRMGLALTAMNKFEEAVTSYQKALDLDPENDSYKSNLK----- 194

  Fly   131 VEERSARNAKTSTKVKQMMDLTFDLATPID 160
            :.|:..|...:.|..    .||||:|:.|:
  Rat   195 IAEQKLREVSSPTGT----GLTFDMASLIN 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	25/68 (37%)
		TPR repeat	16..41	CDD:276809	9/24 (38%)
		TPR repeat	46..79	CDD:276809	14/32 (44%)
		TPR_11	50..115	CDD:290150	24/64 (38%)
		TPR	50..83	CDD:197478	14/32 (44%)
		UNC45-central	351..494	CDD:288539
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
Sgtb	NP_853660.1	SGTA_dimer	7..64	CDD:293154
		TPR 1	15..49
		TPR_11	84..149	CDD:290150	25/67 (37%)
		TPR 2	85..118		11/32 (34%)
		TPR_1	85..118	CDD:278916	11/32 (34%)
		TPR repeat	85..113	CDD:276809	10/27 (37%)
		TPR_11	118..184	CDD:290150	24/68 (35%)
		TPR repeat	118..148	CDD:276809	14/32 (44%)
		TPR_1	119..152	CDD:278916	14/32 (44%)
		TPR 3	120..152		13/31 (42%)
		TPR 4	153..186		12/32 (38%)
		TPR_1	153..186	CDD:278916	12/32 (38%)
		TPR repeat	153..181	CDD:276809	10/27 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840