Protein Alignment unc-45 and unc45b

DIOPT Version :10

• Sequence 1: NP_524796.1
• Gene: unc-45 / 44910
• FlyBaseID: FBgn0288846
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_705959.1
• Gene: unc45b / 266640
• ZFINID: ZDB-GENE-020919-3
• Length: 934
• Species: Danio rerio
• Alignment Length: 934
• Identity: 340/934 - (36%)
• Similarity: 569/934 - (60%)
• Gaps: 18/934 - (1%)

  Fly     9 EVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKH--KELAVFYKNRAAAYLKLGKYENAVE 71
            |:.|:...|::||:.|:|...::|::.|.||||...|.  |.|||.|:||:|.:||...|.||..
Zfish     5 EIGDSVQLKEEGNKHFQAGEIDQAIDCYTKAIKTCKKEDKKALAVIYRNRSACFLKKENYSNAAS 69

  Fly    72 DCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSA 136
            |.|:::.....|.|||:||.||:|.|.|.:.|:||.......:|.|||....|:||...::::..
Zfish    70 DATKAIDVDAADIKALYRRCQAFEKLGKLDMAFKDVQRCATIEPKNKTFLETLRRLGAEIQQKLK 134

  Fly   137 RNAKTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQ 201
            ....|.::|:.|.|:.|......:||..|||||:|||:|..|||.:::::.:..:..|....|.:
Zfish   135 TTFSTDSRVQNMFDILFSDEPDKEKREKAANNLIVLAREDAGAERIFQNNGVPLLMQLIDTGKPE 199

  Fly   202 DIYVNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNALSGLKNK 266
            .| :..:..::.:|.....|...::..:|:.....::...:|..........|.:.::||| .:|
Zfish   200 MI-LAAIRTLSGMCTGHRARATAIIHSVGISKLCSIMAVDNEEIALATANLFQCVNDSLSG-GDK 262

  Fly   267 PDSKPEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELITRNV---HYTALEWAERLVE 328
            .:...|:.|...:::::..:|..|:..|..:.:||..||..:.|:|:||   :..:.:.::.|..
Zfish   263 RNYGKEEALVLDSSKDLKDILLALLEMIASKNVSGHGRDQALNLLTKNVPRQNKKSTDNSKCLFT 327

  Fly   329 I-RGLCRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDEYIKDK 392
            | .||.::|.||.::.|  ....:.:|.::..||||.|:::|:::..|..:.:|.|..|:|||.|
Zfish   328 IDHGLKKILKVCGQVPD--LPDQLPMTENTQLIASVLLSKLYDDLRCDPERDQFRDICDDYIKSK 390

  Fly   393 LLAPDMESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLIAASSK 457
            ....||:..:.....::.:|.||.|:||.:..|:|:::|::|:..::.|:.|.|:.|.||.||:|
Zfish   391 FDPNDMDKNIHAINTLSGILQGPFDLGNVLAGRQGVMEMMVALCGSEREVDQLVAVEALIHASTK 455

  Fly   458 KDKAKALCEQGVDILKRLY-HSKNDGIRVRALVGLCKLGSYGGQDAAIRPFGDGAALKLAEACRR 521
            ..||......||.:||.:| .:||:.|::|||||||||||.||.|.::|.|.:|:..|||:.||:
Zfish   456 TSKASFFISNGVSLLKEMYKKTKNEKIKIRALVGLCKLGSAGGDDYSMRQFAEGSTEKLAKQCRK 520

  Fly   522 FLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDLARGGNQSCLYGVVTTFVNLC 586
            :|..|..|...|:||.:||||||.||:.|:...||:.::.|:.:|.:..:::.||.|..|.||..
Zfish   521 WLCNPTLDVRTRKWAIEGLAYLTNDADVKDDFAEDEPAMRAMFELTKSNDKTILYAVACTLVNCT 585

  Fly   587 NAYEKQEMLPEMIELAKFAKQHIPEEHELDDVDFINKRITVLANEGITTALCALAKTE----SHN 647
            |:|:|:|::|||::||||:|||:||:|..|..|||.:|:..|...|:|:||..:.|.:    :..
Zfish   586 NSYDKKEIIPEMVQLAKFSKQHVPEQHPKDKKDFIVRRVKRLLKAGVTSALAVMVKADNSILTDQ 650

  Fly   648 SQELIARVLNAVCGLKELRGKVVQEGGVKALLRMALEGTEKGKRHATQALARIGITINPEVSFSG 712
            ::|::|||..|:....:.||.:|.:||.|||:.:|||||:|||..|:.|||:|....|||::|.|
Zfish   651 TKEMLARVFLALTEDVKDRGIIVAQGGGKALIPLALEGTDKGKIKASHALAKIAAVSNPEIAFPG 715

  Fly   713 QRSLDVIRPLLNLLQQDCTALENFESLMALTNLASMNESVRQRIIKEQGVSKIEYYLMEDHLYLT 777
            :|..:|:|||::||..|...:||||:|..|||||.:|:.:|.:|:||:.:.:||.|:.|||..:.
Zfish   716 ERIYEVVRPLVSLLGTDRDGMENFEALRGLTNLAGLNDKLRVKILKEKALPEIENYMFEDHEQIR 780

  Fly   778 RAAAQCLCNLVMSEDV-IKMFEGNNDRVKFLALLCEDEDEETATACAGALAIITSVSVKCCEKIL 841
            :||.:|:||||..::| .:..|..||::|.|.|||.:::|:...|.|||||::|:...|...|:.
Zfish   781 QAATECMCNLVCCKEVQDRYLEDGNDKLKLLVLLCGEDEEKLQRAAAGALAMLTAAQKKLAVKMT 845

  Fly   842 AIA-SWLDILHTLIANPSPAVQHRGIVIILNMINAGEEIAKKLFETDIMELLSGLGQLPDDTRAK 905
            .:. .||:||..|..:.:|.:||||:|.:.||::|.:::||||.|:|::|:|:.:.:|.|:.:.:
Zfish   846 KVTEQWLEILQRLCIHDNPEIQHRGLVTVFNMLDADDQLAKKLVESDMLEILTYVAKLEDNPKKQ 910

  Fly   906 -AREVATQCLAAAERYRIIERSDN 928
             |.:.|..||:.|....:|:...|
Zfish   911 NAIDAARACLSKAMDNGLIKPFSN 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_524796.1	3a0801s09	7..>127	CDD:273380	48/119 (40%)
		TPR repeat	16..41	CDD:276809	9/24 (38%)
		TPR repeat	46..79	CDD:276809	15/34 (44%)
		UNC45-central	351..494	CDD:432011	53/143 (37%)
		PLN03200	399..>700	CDD:215629	129/305 (42%)
		armadillo repeat	753..789	CDD:293788	16/35 (46%)
		armadillo repeat	795..826	CDD:293788	12/30 (40%)
unc45b	NP_705959.1	3a0801s09	<9..>139	CDD:273380	48/129 (37%)
		TPR 1. /evidence=ECO:0000255	9..42		11/32 (34%)
		TPR repeat	12..37	CDD:276809	9/24 (38%)
		TPR repeat	42..77	CDD:276809	15/34 (44%)
		TPR 2. /evidence=ECO:0000255	48..81		13/32 (41%)
		TPR repeat	82..108	CDD:276809	13/25 (52%)
		TPR 3. /evidence=ECO:0000255	83..115		14/31 (45%)
		ARM 1. /evidence=ECO:0000255	174..213		6/39 (15%)
		armadillo repeat	177..213	CDD:293788	5/36 (14%)
		ARM 2. /evidence=ECO:0000255	216..255		4/38 (11%)
		UNC45-central	349..493	CDD:432011	53/143 (37%)
		ARM 3. /evidence=ECO:0000255	753..792		16/38 (42%)
		armadillo repeat	756..790	CDD:293788	14/33 (42%)
		armadillo repeat	798..830	CDD:293788	12/31 (39%)