DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc-45 and unc45b

DIOPT Version :9

Sequence 1:NP_001303425.1 Gene:unc-45 / 44910 FlyBaseID:FBgn0010812 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_705959.1 Gene:unc45b / 266640 ZFINID:ZDB-GENE-020919-3 Length:934 Species:Danio rerio


Alignment Length:934 Identity:340/934 - (36%)
Similarity:569/934 - (60%) Gaps:18/934 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 EVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKH--KELAVFYKNRAAAYLKLGKYENAVE 71
            |:.|:...|::||:.|:|...::|::.|.||||...|.  |.|||.|:||:|.:||...|.||..
Zfish     5 EIGDSVQLKEEGNKHFQAGEIDQAIDCYTKAIKTCKKEDKKALAVIYRNRSACFLKKENYSNAAS 69

  Fly    72 DCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSA 136
            |.|:::.....|.|||:||.||:|.|.|.:.|:||.......:|.|||....|:||...::::..
Zfish    70 DATKAIDVDAADIKALYRRCQAFEKLGKLDMAFKDVQRCATIEPKNKTFLETLRRLGAEIQQKLK 134

  Fly   137 RNAKTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQ 201
            ....|.::|:.|.|:.|......:||..|||||:|||:|..|||.:::::.:..:..|....|.:
Zfish   135 TTFSTDSRVQNMFDILFSDEPDKEKREKAANNLIVLAREDAGAERIFQNNGVPLLMQLIDTGKPE 199

  Fly   202 DIYVNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNALSGLKNK 266
            .| :..:..::.:|.....|...::..:|:.....::...:|..........|.:.::||| .:|
Zfish   200 MI-LAAIRTLSGMCTGHRARATAIIHSVGISKLCSIMAVDNEEIALATANLFQCVNDSLSG-GDK 262

  Fly   267 PDSKPEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELITRNV---HYTALEWAERLVE 328
            .:...|:.|...:::::..:|..|:..|..:.:||..||..:.|:|:||   :..:.:.::.|..
Zfish   263 RNYGKEEALVLDSSKDLKDILLALLEMIASKNVSGHGRDQALNLLTKNVPRQNKKSTDNSKCLFT 327

  Fly   329 I-RGLCRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDEYIKDK 392
            | .||.::|.||.::.|  ....:.:|.::..||||.|:::|:::..|..:.:|.|..|:|||.|
Zfish   328 IDHGLKKILKVCGQVPD--LPDQLPMTENTQLIASVLLSKLYDDLRCDPERDQFRDICDDYIKSK 390

  Fly   393 LLAPDMESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLIAASSK 457
            ....||:..:.....::.:|.||.|:||.:..|:|:::|::|:..::.|:.|.|:.|.||.||:|
Zfish   391 FDPNDMDKNIHAINTLSGILQGPFDLGNVLAGRQGVMEMMVALCGSEREVDQLVAVEALIHASTK 455

  Fly   458 KDKAKALCEQGVDILKRLY-HSKNDGIRVRALVGLCKLGSYGGQDAAIRPFGDGAALKLAEACRR 521
            ..||......||.:||.:| .:||:.|::|||||||||||.||.|.::|.|.:|:..|||:.||:
Zfish   456 TSKASFFISNGVSLLKEMYKKTKNEKIKIRALVGLCKLGSAGGDDYSMRQFAEGSTEKLAKQCRK 520

  Fly   522 FLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDLARGGNQSCLYGVVTTFVNLC 586
            :|..|..|...|:||.:||||||.||:.|:...||:.::.|:.:|.:..:::.||.|..|.||..
Zfish   521 WLCNPTLDVRTRKWAIEGLAYLTNDADVKDDFAEDEPAMRAMFELTKSNDKTILYAVACTLVNCT 585

  Fly   587 NAYEKQEMLPEMIELAKFAKQHIPEEHELDDVDFINKRITVLANEGITTALCALAKTE----SHN 647
            |:|:|:|::|||::||||:|||:||:|..|..|||.:|:..|...|:|:||..:.|.:    :..
Zfish   586 NSYDKKEIIPEMVQLAKFSKQHVPEQHPKDKKDFIVRRVKRLLKAGVTSALAVMVKADNSILTDQ 650

  Fly   648 SQELIARVLNAVCGLKELRGKVVQEGGVKALLRMALEGTEKGKRHATQALARIGITINPEVSFSG 712
            ::|::|||..|:....:.||.:|.:||.|||:.:|||||:|||..|:.|||:|....|||::|.|
Zfish   651 TKEMLARVFLALTEDVKDRGIIVAQGGGKALIPLALEGTDKGKIKASHALAKIAAVSNPEIAFPG 715

  Fly   713 QRSLDVIRPLLNLLQQDCTALENFESLMALTNLASMNESVRQRIIKEQGVSKIEYYLMEDHLYLT 777
            :|..:|:|||::||..|...:||||:|..|||||.:|:.:|.:|:||:.:.:||.|:.|||..:.
Zfish   716 ERIYEVVRPLVSLLGTDRDGMENFEALRGLTNLAGLNDKLRVKILKEKALPEIENYMFEDHEQIR 780

  Fly   778 RAAAQCLCNLVMSEDV-IKMFEGNNDRVKFLALLCEDEDEETATACAGALAIITSVSVKCCEKIL 841
            :||.:|:||||..::| .:..|..||::|.|.|||.:::|:...|.|||||::|:...|...|:.
Zfish   781 QAATECMCNLVCCKEVQDRYLEDGNDKLKLLVLLCGEDEEKLQRAAAGALAMLTAAQKKLAVKMT 845

  Fly   842 AIA-SWLDILHTLIANPSPAVQHRGIVIILNMINAGEEIAKKLFETDIMELLSGLGQLPDDTRAK 905
            .:. .||:||..|..:.:|.:||||:|.:.||::|.:::||||.|:|::|:|:.:.:|.|:.:.:
Zfish   846 KVTEQWLEILQRLCIHDNPEIQHRGLVTVFNMLDADDQLAKKLVESDMLEILTYVAKLEDNPKKQ 910

  Fly   906 -AREVATQCLAAAERYRIIERSDN 928
             |.:.|..||:.|....:|:...|
Zfish   911 NAIDAARACLSKAMDNGLIKPFSN 934

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-45NP_001303425.1 TPR_11 12..81 CDD:290150 28/70 (40%)
TPR repeat 16..41 CDD:276809 9/24 (38%)
TPR repeat 46..79 CDD:276809 15/34 (44%)
TPR_11 50..115 CDD:290150 27/64 (42%)
TPR 50..83 CDD:197478 13/32 (41%)
UNC45-central 351..494 CDD:288539 53/143 (37%)
ARM 668..788 CDD:237987 58/119 (49%)
armadillo repeat 753..789 CDD:293788 16/35 (46%)
armadillo repeat 795..826 CDD:293788 12/30 (40%)
unc45bNP_705959.1 TPR_11 8..78 CDD:290150 28/69 (41%)
TPR 1. /evidence=ECO:0000255 9..42 11/32 (34%)
TPR repeat 12..37 CDD:276809 9/24 (38%)
TPR repeat 42..77 CDD:276809 15/34 (44%)
TPR_11 48..113 CDD:290150 27/64 (42%)
TPR 2. /evidence=ECO:0000255 48..81 13/32 (41%)
TPR repeat 82..108 CDD:276809 13/25 (52%)
TPR 3. /evidence=ECO:0000255 83..115 14/31 (45%)
ARM <171..250 CDD:237987 12/79 (15%)
ARM 1. /evidence=ECO:0000255 174..213 6/39 (15%)
armadillo repeat 177..213 CDD:293788 5/36 (14%)
ARM 2. /evidence=ECO:0000255 216..255 4/38 (11%)
UNC45-central 349..493 CDD:288539 53/143 (37%)
ARM 720..835 CDD:237987 51/114 (45%)
ARM 3. /evidence=ECO:0000255 753..792 16/38 (42%)
armadillo repeat 756..790 CDD:293788 14/33 (42%)
armadillo repeat 798..830 CDD:293788 12/31 (39%)
ARM 808..>897 CDD:237987 36/88 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170590870
Domainoid 1 1.000 366 1.000 Domainoid score I874
eggNOG 1 0.900 - - E1_KOG4151
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H14666
Inparanoid 1 1.050 633 1.000 Inparanoid score I812
OMA 1 1.010 - - QHG45249
OrthoDB 1 1.010 - - D1059433at2759
OrthoFinder 1 1.000 - - FOG0002389
OrthoInspector 1 1.000 - - otm26016
orthoMCL 1 0.900 - - OOG6_103191
Panther 1 1.100 - - O PTHR45994
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3298
SonicParanoid 1 1.000 - - X2500
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1615.800

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