DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-45 and rng3

DIOPT Version :9

Sequence 1:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_587692.1	Gene:	rng3 / 2539360	PomBaseID:	SPCC613.04c	Length:	746	Species:	Schizosaccharomyces pombe

Alignment Length:	776	Identity:	183/776 - (23%)
Similarity:	316/776 - (40%)	Gaps:	173/776 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 VHLVAALCENSVE-------RTKGVLTELGVPWFMRVLDQKHENCVSTAQFCL---QTILNALSG 262
            :.|:..:.:||||       :.|.::|        .:|..|    :|||...|   .|..:..:.
pombe    11 IDLLNDILKNSVESNVFSDYQKKQIVT--------LILKSK----ISTAIVLLSPKSTAASEWNY 63

  Fly   263 LKNKPDSKPEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELITRNVHYTALEWAE--- 324
            |.|..|.. |..||      :||:|...:.:|..|..|      ::.|...|      :|.:
pombe    64 LCNLQDLH-ECVLC------VDTILPANLQTIAKRIFS------LVLLPPLN------DWCKQLR 109

  Fly   325 ----RLVEIRGLC----------------RLLDVCSELEDYKYESAM--DITGSSSTIASVCLAR 367
                |.|....:|                .||.|..::...|.:..:  ::..|.|:|.:..:||
pombe   110 DAFLRFVSQPSICPTDFPLKLFFLSTVGIELLIVNEKIIPQKTQKYLLYELFSSPSSITANEIAR 174

  Fly   368 IYENMYYDEAKARFTDQIDEYIKDKLLAPDMESKVRVTVAITALLNGP-LDVGNQVVAREG--IL 429
            :.:     ||..|      .|:        ::|....|.|..|.||.| ..:.:.::.::|  .|
pombe   175 LCQ-----EANNR------NYL--------LQSLTSATDARRAFLNNPNYRLLSAIIFQDGPSNL 220

  Fly   430 QMILA-----MATTDDELQ---QRVSCECLIAASSKKD--------------KAKALCEQGVDIL 472
            ..:||     :|...:.:.   :|:|...|:...|..|              :...|.|:.::||
pombe   221 AFVLAKDCVLLARQPETIPVSFERMSSLLLMCLPSHPDFISPEFCHEWTELAERNGLQEEWLNIL 285

  Fly   473 ---------KRLYHSK-------NDGIRVRALVGLCKLGSYGGQDAAIRPFGDGAALKLAEACRR 521
                     :.:.|.:       |...||..|:.: || ::..|.:.:.|     .|||
pombe   286 NTACNFKECRAIIHKECSEFIKDNHTSRVAILISM-KL-AFQYQLSQVIP-----TLKL------ 337

  Fly   522 FLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDLARGGNQSCL--YGVVTTFVN 584
             |:   :.|.......:.|...:.....|:.:.:|...::.|..|....|.|.|  ..:.|...|
pombe   338 -LL---QSKVYDSVLLEALRQSSTLGPVKQLIADDSCLLNNLSKLLLDTNISPLDASSIATIIYN 398

  Fly   585 LCN-AYEKQEMLPEMIELAKFAKQHIPEEHELDDVDFINKRITVLANEGITTALCALAKTESHNS 648
            :|. ...|.|...|:.:|...|:.....:::.|:.....:||..:....|.:.|.:.||  .:||
pombe   399 MCKFKITKSEHERELNQLRNMAEASKTIDYKEDETAPTERRIQKILEYDILSKLFSAAK--HYNS 461

  Fly   649 -QELIARVLNAVCGLKELRGKVVQEGGVKALLRMALEGTEKGKRHATQALARIGITINPE----V 708
             ..|:|.:|..:...|..|.|:||.|.:|.|.|.....|:..  :|..|||:|.|::.|.    .
pombe   462 LNGLLAMILVHMANYKLARRKLVQIGALKFLTRQCFIQTQDS--NAAFALAKILISVAPHSIFTK 524

  Fly   709 SFSGQRSLDVIRPLLNLLQQDCTALE------NFESLMALTNLASMNESVRQRIIKEQGVSKIEY 767
            :|...|:   |.|:..||..:....|      .||.|:|||||||.:|..||.|::|.. .:::.
pombe   525 AFPSNRA---IHPMSKLLSTNSADTEYPILLGKFEVLLALTNLASHDEESRQAIVQECW-RELDE 585

  Fly   768 YLMEDHLYLTRAAAQCLCNLVMSEDVIKMFEGNND------RVKFLALLCEDEDEETATACAGAL 826
            .::|.:..:.||..:.:.||.:|...:..|.|:.|      |:..:..|.:.||..|..|..|.|
pombe   586 LIIETNPLIQRATTELINNLSLSPYCLIKFIGDKDSDFENTRLHIVLALSDTEDTPTRLAACGIL 650

  Fly   827 AIITSVSVKCCEKILAIASWLDILHTLIANPSPAVQHRGIVIILNMI-NAGEEIAKKLFET 886
            ..||||. :.|:|||::.:..:.:..::.:....:||||:|.|.|:: :..:||..|..:|
pombe   651 VQITSVD-EGCKKILSLQNDFNYIVRMLTDQDEGIQHRGLVCICNIVYSKDQEIFNKFIKT 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150
		TPR repeat	16..41	CDD:276809
		TPR repeat	46..79	CDD:276809
		TPR_11	50..115	CDD:290150
		TPR	50..83	CDD:197478
		UNC45-central	351..494	CDD:288539	35/185 (19%)
		ARM	668..788	CDD:237987	41/129 (32%)
		armadillo repeat	753..789	CDD:293788	9/35 (26%)
		armadillo repeat	795..826	CDD:293788	10/36 (28%)
rng3	NP_587692.1	armadillo repeat	523..566	CDD:293788	15/45 (33%)
		ARM	531..655	CDD:237987	38/127 (30%)
		armadillo repeat	572..605	CDD:293788	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4151
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002389
OrthoInspector	1	1.000	-	-		oto102127
orthoMCL	1	0.900	-	-		OOG6_103191
Panther	1	1.100	-	-	LDO	PTHR45994
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810