DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-45 and Ttc12

DIOPT Version :9

Sequence 1:NP_001303425.1 Gene:unc-45 / 44910 FlyBaseID:FBgn0010812 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_766358.1 Gene:Ttc12 / 235330 MGIID:2444588 Length:704 Species:Mus musculus


Alignment Length:879 Identity:174/879 - (19%)
Similarity:296/879 - (33%) Gaps:334/879 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 AGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTESL 77
            |.:.|:||||||....:|.|:..|.:.:   .|.|::.|.|.|||.|::|||.|:.|:.||..:|
Mouse   105 ADALKEKGNEAFVRGDYETAIFFYSEGL---GKLKDMKVLYTNRAQAFIKLGDYQKALVDCDWAL 166

  Fly    78 KAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSARNAKTS 142
            |......||.|...:|:.||:.:.:|                     :..:..:||   .|.|..
Mouse   167 KCDENCTKAYFHMGKAHVALKNYSKA---------------------KECYQKIEE---INPKLK 207

  Fly   143 TKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQDIYVNM 207
            .:||:.:                  |.|.|.::                |.|.:.|..:.:... 
Mouse   208 AQVKEHL------------------NQVTLREK----------------ADLQEKEAQESLDSG- 237

  Fly   208 VHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNALSGLKNKPDSKPE 272
                    :|:...||.:|..|..|.                    ||.|....|::        
Mouse   238 --------KNTAVTTKNLLETLSKPG--------------------QTPLFYAGGIE-------- 266

  Fly   273 KELCTRNNREIDTLLTCLVYSITDRTI----SGAARDGVIELITRNVHYTALEWAERLVEIRGLC 333
                         :||.::...|:||:    .|.:.....|:|.|.:..|..:..|.::.:..|.
Mouse   267 -------------ILTEMMADCTERTLFRTYGGFSTISDHEVIRRCLFLTGKDAVEEVLCVSVLK 318

  Fly   334 RLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDEYIKDKLLAPDM 398
            ...:||.:.|:          .....:....:||:                :..::..::|....
Mouse   319 LWQEVCVDNEE----------NQRLLVTHPDMARL----------------LPSFMTSRILVIQQ 357

  Fly   399 ESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLIAASSKKDKAKA 463
            :| :.:.:.:|...||    .|||:....:.|:                ||.|::..:..|| ||
Mouse   358 QS-LDLLLQLTQTENG----RNQVIKHLDMTQL----------------CEALLSFLAFSDK-KA 400

  Fly   464 LCEQGV-------------------DILKRLYHSKNDGIRVRALVGLCK----LGSYGGQDAAIR 505
            ....|:                   |:|..|..:.|...::.:...||:    ||:...:..|.:
Mouse   401 NTAIGILTDLALEERFQVWFQTNLPDVLPALTGALNREPKITSPSALCQCIALLGNISAEPTARK 465

  Fly   506 ------PFGDGAALKLAEACRRFLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALM 564
                  .||:        ||...|:|                       |:|.           |
Mouse   466 HMIAHEEFGN--------ACLDLLVK-----------------------CEED-----------M 488

  Fly   565 DLARGGNQSCLYGVVTTFVNLCNAYEKQEMLPEMIELAKFAKQHIPEEHELDDVDFINKRITVL- 628
            ||.|    ...|.::...:|||            :|:...::..:        |....|.:::| 
Mouse   489 DLFR----EITYTLLGLIMNLC------------LEITFLSEMWV--------VKMSRKCLSLLN 529

  Fly   629 ANEG--ITTALCALAKTESHNSQELIARVLNAVCGLKELRGKVVQEGGVKALLRMALEGTEKGKR 691
            :.:|  :|.|...|::|.| :||.::...|.|              |.||.:::....|.:...|
Mouse   530 SKDGGILTRAAGVLSRTLS-SSQTIVEEALTA--------------GVVKKMIKFLRMGGQTASR 579

  Fly   692 HATQALARIGITINPEVSFSGQRSLDVIRPLLNLLQQDCTALENFESLMALTNLASMNESVRQRI 756
            :|.:.||   |..|   |....|. :|:|  |:         :.|:.||.|  |||         
Mouse   580 YAIKILA---ICTN---SCHAARE-EVVR--LD---------KKFDLLMLL--LAS--------- 615

  Fly   757 IKEQGVSKIEYYLMEDHLYLTRAAAQCLCNLV----MSEDVIKMFEGNNDRVKFLALLCEDEDEE 817
                          ||.: |...||.||.|.:    .:..::|     .|.|:.|..|...:.:|
Mouse   616 --------------EDEI-LAGNAALCLGNCMEVPSAAPSLLK-----TDIVRVLLKLAGSDSKE 660

  Fly   818 TATACAGALAIITSVSVKCCEKILAIASWLDILH 851
            |.......:|:     .|.|......|:.|..||
Mouse   661 TGVQLNAGIAL-----GKLCTAEPRFAAQLRELH 689

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-45NP_001303425.1 TPR_11 12..81 CDD:290150 28/67 (42%)
TPR repeat 16..41 CDD:276809 10/24 (42%)
TPR repeat 46..79 CDD:276809 15/32 (47%)
TPR_11 50..115 CDD:290150 22/64 (34%)
TPR 50..83 CDD:197478 15/32 (47%)
UNC45-central 351..494 CDD:288539 25/165 (15%)
ARM 668..788 CDD:237987 30/119 (25%)
armadillo repeat 753..789 CDD:293788 8/39 (21%)
armadillo repeat 795..826 CDD:293788 7/30 (23%)
Ttc12NP_766358.1 TPR_11 105..170 CDD:290150 28/67 (42%)
TPR 1 105..138 13/35 (37%)
TPR repeat 105..133 CDD:276809 11/30 (37%)
TPR repeat 138..168 CDD:276809 14/29 (48%)
TPR 2 139..172 15/32 (47%)
TPR_11 141..204 CDD:290150 23/86 (27%)
TPR_1 142..172 CDD:278916 14/29 (48%)
TPR 3 173..206 10/56 (18%)
TPR repeat 173..198 CDD:276809 7/45 (16%)
TPR_1 174..205 CDD:278916 10/54 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846134
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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