Protein Alignment unc-45 and UNC45B

DIOPT Version :10

• Sequence 1: NP_524796.1
• Gene: unc-45 / 44910
• FlyBaseID: FBgn0288846
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_775259.1
• Gene: UNC45B / 146862
• HGNCID: 14304
• Length: 931
• Species: Homo sapiens
• Alignment Length: 927
• Identity: 324/927 - (34%)
• Similarity: 550/927 - (59%)
• Gaps: 17/927 - (1%)

  Fly    12 DAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTES 76
            :|...|::||..|:...::.|...|.:|:|.......||..|:||||..||...|..|..|.:.:
Human     5 EAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASRA 69

  Fly    77 LKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSARNAKT 141
            :.....|.|||:||.||.|.|.|.::|:||.......:|.|:..|.||:||:..::|:......|
Human    70 IDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSIQEKLRVQFST 134

  Fly   142 STKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQDIYVN 206
            .::|::|.::..|..:..|||..|||||:||.:|:.|||.:::::.:|.:..|...:| .::.:.
Human   135 DSRVQKMFEILLDENSEADKREKAANNLIVLGREEAGAEKIFQNNGVALLLQLLDTKK-PELVLA 198

  Fly   207 MVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNALSGLKNKPDSKP 271
            .|..::.:|.....|...:|..:.:.....::..::|.........||.|:::|||...:.....
Human   199 AVRTLSGMCSGHQARATVILHAVRIDRICSLMAVENEEMSLAVCNLLQAIIDSLSGEDKREHRGK 263

  Fly   272 EKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELITRNV--HYTALEWAERLVEI--RGL 332
            |:.|.....:::..:.:.|:..:..:.:||..||..:.|:.:||  ...|:....|.:.:  .||
Human   264 EEALVLDTKKDLKQITSHLLDMLVSKKVSGQGRDQALNLLNKNVPRKDLAIHDNSRTIYVVDNGL 328

  Fly   333 CRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDEYIKDKLLAPD 397
            .::|.|..::.|  ..|.:.:|.::..:||:.:.::|:::..|..:..|....:|||..|....|
Human   329 RKILKVVGQVPD--LPSCLPLTDNTRMLASILINKLYDDLRCDPERDHFRKICEEYITGKFDPQD 391

  Fly   398 MESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLIAASSKKDKAK 462
            |:..:.....::.:|.||.|:|||::..:|:::|::|:..::.|..|.|:.|.||.||:|..:|.
Human   392 MDKNLNAIQTVSGILQGPFDLGNQLLGLKGVMEMMVALCGSERETDQLVAVEALIHASTKLSRAT 456

  Fly   463 ALCEQGVDILKRLYH-SKNDGIRVRALVGLCKLGSYGGQDAAIRPFGDGAALKLAEACRRFLIKP 526
            .:...||.:||::|. :||:.|::|.|||||||||.||.|..:|.|.:|:..|||:.||::|...
Human   457 FIITNGVSLLKQIYKTTKNEKIKIRTLVGLCKLGSAGGTDYGLRQFAEGSTEKLAKQCRKWLCNM 521

  Fly   527 GKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDLARGG--NQSCLYGVVTTFVNLCNAY 589
            ..|...||||.:|||||||||:.|:..::|..::.|:.:||:.|  :::.||.|.||.||..|:|
Human   522 SIDTRTRRWAVEGLAYLTLDADVKDDFVQDVPALQAMFELAKAGTSDKTILYSVATTLVNCTNSY 586

  Fly   590 EKQEMLPEMIELAKFAKQHIPEEHELDDVDFINKRITVLANEGITTALCALAKTES----HNSQE 650
            :.:|::||:::||||:|||:||||..|..|||:.|:..|...|:.:||..:.|.:|    ..::|
Human   587 DVKEVIPELVQLAKFSKQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKE 651

  Fly   651 LIARVLNAVCGLKELRGKVVQEGGVKALLRMALEGTEKGKRHATQALARIGITINPEVSFSGQRS 715
            |:|||..|:|...:.||.:|.:||.|||:.:|||||:.||..|..|||:|....||:::|.|:|.
Human   652 LLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERV 716

  Fly   716 LDVIRPLLNLLQQDCTALENFESLMALTNLASMNESVRQRIIKEQGVSKIEYYLMEDHLYLTRAA 780
            .:|:|||:.||......|:|:|:|:.||||:..::.:||:|.||:.:..||.|:.|:|..|.:||
Human   717 YEVVRPLVRLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAA 781

  Fly   781 AQCLCNLVMSEDVIKMF-EGNNDRVKFLALLCEDEDEETATACAGALAIITSVSVKCCEKILAIA 844
            .:|:||:|:.::|.:.| ...|||:|.:.|||.::|::...|.|||||::|:...|.|.|:..:.
Human   782 TECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLTAAHKKLCLKMTQVT 846

  Fly   845 S-WLDILHTLIANPSPAVQHRGIVIILNMINAGEEIAKKLFETDIMELLSGLG-QLPDDTRAKAR 907
            : ||:||..|..:...:|||||:||..|::.|..|:||||.|::::|:|:.:| |.||:.:|:..
Human   847 TQWLEILQRLCLHDQLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKKAEVV 911

  Fly   908 EVATQCLAAAERYRIIE 924
            :.|.:||.....|..|:
Human   912 QTARECLIKCMDYGFIK 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-45	NP_524796.1	3a0801s09	7..>127	CDD:273380	40/114 (35%)
		TPR repeat	16..41	CDD:276809	7/24 (29%)
		TPR repeat	46..79	CDD:276809	12/32 (38%)
		UNC45-central	351..494	CDD:432011	46/143 (32%)
		PLN03200	399..>700	CDD:215629	130/307 (42%)
		armadillo repeat	753..789	CDD:293788	16/35 (46%)
		armadillo repeat	795..826	CDD:293788	12/31 (39%)
UNC45B	NP_775259.1	TPR repeat	39..72	CDD:276809	12/32 (38%)
		TPR 2	43..76		11/32 (34%)
		TPR 3	77..110		14/32 (44%)
		TPR repeat	77..103	CDD:276809	13/25 (52%)
		ARM 1	169..208		7/39 (18%)
		armadillo repeat	172..208	CDD:293788	6/36 (17%)
		ARM 2	211..250		6/38 (16%)
		armadillo repeat	214..245	CDD:293788	2/30 (7%)
		UNC45-central	344..489	CDD:432011	46/144 (32%)
		ARM 3	751..790		16/38 (42%)
		armadillo repeat	754..788	CDD:293788	15/33 (45%)
		3a0801s09	<6..>154	CDD:273380	47/147 (32%)
		TPR 1	6..39		9/32 (28%)
		TPR repeat	6..34	CDD:276809	8/27 (30%)