DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc-45 and Unc45a

DIOPT Version :9

Sequence 1:NP_001303425.1 Gene:unc-45 / 44910 FlyBaseID:FBgn0010812 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_598713.2 Gene:Unc45a / 101869 MGIID:2142246 Length:944 Species:Mus musculus


Alignment Length:942 Identity:345/942 - (36%)
Similarity:555/942 - (58%) Gaps:38/942 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 SDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVEDCTE 75
            |.|...:.:|||.||...:|.|:..|.:|:..|:..::.|:.::||||.:|||..|..|..:.::
Mouse    19 SSAEQLRKEGNELFKCGDYEGALTAYTQALSLGATPQDQAILHRNRAACHLKLEDYSKAESEASK 83

  Fly    76 SLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLHVVVEERSARNAK 140
            :::...||.|||:||:||.|.|.:.::|..|.......:|.||..|..|:.:...::|:....:.
Mouse    84 AIEKDGGDVKALYRRSQALEKLGRLDQAVLDLKRCVSLEPKNKVFQESLRNIGGQIQEKVRYMSS 148

  Fly   141 TSTKVKQMMDLTFDLATP----IDKRRAAANNLVVLAKEQTGAELLYKDHCIAKVASLTKVEKDQ 201
            |..||:||..:..|   |    .:|::.|:.||||||:|..|||.:::.:.:..:..|...| :.
Mouse   149 TDAKVEQMFQILLD---PKEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDTE-ET 209

  Fly   202 DIYVNMVHLVAALCENSVERTKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNAL-SGLKN 265
            |:.:..:..:..:|.....||...|:.||....:.:|..:::.....|...||.|.:|| .|:|.
Mouse   210 DLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSILGVENQAVSLAACHLLQVIFDALKEGVKK 274

  Fly   266 KPDSKPEKELCTRNNREIDTLLTCLVYSITDRTISGAARDGVIELITRNV--------HYTALEW 322
            ....| |..:.....||:..|:..|:..:|:..:||..||..:.|:.:.|        :.:...|
Mouse   275 GFRGK-EGAIIVDPARELKVLINSLLELLTEVGVSGQGRDNALTLLIKMVPRKSPKDPNNSLTLW 338

  Fly   323 AERLVEIRGLCRLLDVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDE 387
                |..:||.::|:|...|:|...|  :.:|.:|...||:.|:::::::..|..:..|....:.
Mouse   339 ----VIDQGLKKILEVGGSLQDAAGE--LTVTANSRMSASILLSKLFDDLKCDAERENFHRLCEN 397

  Fly   388 YIKDKLLAPDMESKVRVTVAITALLNGPLDVGNQVVAREGILQMILAMATTDDELQQRVSCECLI 452
            ||::......:..|:|....::.||.||.|.||:.:...|:::.::|:..::.|.:|.|:.|.||
Mouse   398 YIRNWFEGHGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEREEEQLVAVEALI 462

  Fly   453 AASSKKDKAKALCEQGVDILKRLYH-SKNDGIRVRALVGLCKLGSYGGQDAAIRPFGDGAALKLA 516
            .|:.|..:|..:...||.:||.||. |:.|.||:|||||||||||.||.|.:::.|.:|:.||||
Mouse   463 HAAGKAKRASFITANGVSLLKDLYKGSERDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLA 527

  Fly   517 EACRRFLIKPGKDKDIRRWAADGLAYLTLDAECKEKLIEDKASIHALMDLARGGNQSCLYGVVTT 581
            :.||::|.....|...||||.:||||||.||:.||:.:||:|::.||..|:|...:|.|:.|.:.
Mouse   528 KQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDEAALKALFQLSRSEERSVLFAVGSA 592

  Fly   582 FVNLCNAYEKQEMLPEMIELAKFAKQHIPEEHELDDVDFINKRITVLANEGITTALCALAKTES- 645
            .||..|:|:.:|..|:|:||||:||||:||:|..|...|:..|:..|...|:.:|:..:.|||| 
Mouse   593 LVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMTCMVKTESP 657

  Fly   646 ---HNSQELIARVLNAVCGLKELRGKVVQEGGVKALLRMALEGTEKGKRHATQALARIGITINPE 707
               ::.:||::||..|:....|.||.||.:||.||||.:|||||:.|:..|.||||::.||.|||
Mouse   658 VLTNSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSNPE 722

  Fly   708 VSFSGQRSLDVIRPLLNLLQQDCTALENFESLMALTNLASMNESVRQRIIKEQGVSKIEYYLMED 772
            ::|.|:|..:|:|||::||...|:.|:|||:||||||||.::|.:||:|:||:.|..||.|:.|:
Mouse   723 MTFPGERIYEVVRPLVSLLHLSCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEE 787

  Fly   773 HLYLTRAAAQCLCNLVMSEDVIKMFEG-NNDRVKFLALLCEDEDEETATACAGALAIITSVSVKC 836
            |..:.|||.:|:|||.||::|..:||. .|||:|.|.|...::||....|.||.||::||:....
Mouse   788 HEMIRRAATECMCNLAMSKEVQDLFEAQGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPAL 852

  Fly   837 CEKILAIAS-WLDILHTLIANPSPAVQHRGIVIILNMINAGEEIAKKLFETDIMELLSGL--GQL 898
            |.:|..:.: ||:||..|:.:|:..:||||.|::|||:.:.:|||..|.|::::|:||.|  |:.
Mouse   853 CSRIPQVTTHWLEILQALLLSPNQELQHRGTVVVLNMMQSSKEIAGTLMESEVLEILSVLAKGEE 917

  Fly   899 PDDTRAKAREVATQCLAAAERYRIIERSDNAE 930
            ...|||     |..||..|..||:|:.:.:.|
Mouse   918 SPVTRA-----AAACLEKAVEYRLIQPNQDGE 944

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-45NP_001303425.1 TPR_11 12..81 CDD:290150 21/68 (31%)
TPR repeat 16..41 CDD:276809 9/24 (38%)
TPR repeat 46..79 CDD:276809 10/32 (31%)
TPR_11 50..115 CDD:290150 23/64 (36%)
TPR 50..83 CDD:197478 10/32 (31%)
UNC45-central 351..494 CDD:288539 46/143 (32%)
ARM 668..788 CDD:237987 64/119 (54%)
armadillo repeat 753..789 CDD:293788 18/35 (51%)
armadillo repeat 795..826 CDD:293788 13/31 (42%)
Unc45aNP_598713.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25 2/5 (40%)
3a0801s09 7..>115 CDD:273380 34/95 (36%)
TPR 1 21..54 11/32 (34%)
TPR repeat 21..49 CDD:276809 10/27 (37%)
TPR repeat 57..87 CDD:276809 10/29 (34%)
TPR 2 58..91 10/32 (31%)
TPR 3 92..125 12/32 (38%)
TPR repeat 92..120 CDD:276809 11/27 (41%)
UNC45-central 361..505 CDD:371677 46/143 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846140
Domainoid 1 1.000 373 1.000 Domainoid score I884
eggNOG 1 0.900 - - E1_KOG4151
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 597 1.000 Inparanoid score I947
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45249
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002389
OrthoInspector 1 1.000 - - otm44312
orthoMCL 1 0.900 - - OOG6_103191
Panther 1 1.100 - - LDO PTHR45994
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3298
SonicParanoid 1 1.000 - - X2500
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.790

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