DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp7 and larp7

DIOPT Version :9

Sequence 1:	NP_524795.2	Gene:	Larp7 / 44900	FlyBaseID:	FBgn0260771	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_001039168.1	Gene:	larp7 / 734000	XenbaseID:	XB-GENE-984850	Length:	593	Species:	Xenopus tropicalis

Alignment Length:	657	Identity:	182/657 - (27%)
Similarity:	292/657 - (44%)	Gaps:	164/657 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AAPTEPAEENSKEPAPEDASPDKKDGGRKRKRHLFNSIRGQMEFYFGDANLSKDRFLRRYVE--Q 88
            |..|:......||....|...|::...|.|.:.|...|..|::|:|||.||.||||||..:|  :
Frog     3 AIETDTPSNKVKEDESTDLRKDREKKKRSRVKQLLADIAKQVDFWFGDVNLHKDRFLREQIEKTR 67

  Fly    89 DPYVPLEIFLTFNKIKTLTQDVQQIAKALSNSQLLELDETELKVKRRTKLPDQ-RDVNDKTLYVE 152
            |.|:.:.:..:|||:|.:|.|.:.||:|:.||.::|::.:..|::||..|.:: :||:.:|:|||
Frog    68 DGYIDISLLASFNKMKKITTDSKLIARAVKNSSVVEINLSGTKIRRRFPLGEKPQDVDSRTVYVE 132

  Fly   153 ALPANATHDWLKEVFSRYGPVAYVSLPHYPGTKKIKEFAFIEFE--------------------- 196
            .||.|.||.|::.||.:||.|.|||:|.|..|...|.|||||||
Frog   133 LLPKNVTHSWIERVFGKYGMVVYVSIPRYKSTGDPKGFAFIEFETQEQAAKAIEVLNNPPEEAPR 197

  Fly   197 KSGSLEKAVKAFAQIQGVLSVE-TDPSDLASVRSFQQQQQIQQKAEQPQSEAEQVE--------- 251
            |:|...|.||.    :.:..|| |:.|......:.:::::.::|::..:...|:.|
Frog   198 KAGMFPKTVKN----KHLPPVEVTEHSITEGCGTEEKKKKKKKKSKARKDSVEKAEEDTKEQDMD 258

  Fly   252 -----LPKR------------------NLKREATDKDR-------EEIHEVKRVKLEEGQPSETS 286
                 :|||                  ..|:|...|:|       |::.:.|| |....:..:.|
Frog   259 IISEGVPKRRKTVSESSVPDVQEADKQTAKKEKKKKERAESFDQSEKVRQGKR-KCSSSEEHDCS 322

  Fly   287 TAGETASETD--------------AEGTAEASEQEDKTEATDGDE-AAKKRRRKRKKKAIVDKPN 336
            :|.:..|:|.              .:...|.|.:|:| :|.|..| :..|.:||||||. .::..
Frog   323 SAKQKKSDTKDLPQDEKPMVTQEVLQECKELSTEEEK-DAVDKKEISVPKVKRKRKKKH-KERHR 385

  Fly   337 IEPSALELKVLPKTSWSSMRNKYLNLQRRIVSEAKSKLWRENHPQNQQHPHHQQTSHPNHPKPSQ 401
            :....:.|:||.||.|..::.:||.|||..::..|..:...||...::    .||      :||.
Frog   386 VGEEVIPLRVLSKTEWLVLKAEYLTLQRASMASLKKSMSEMNHISEEE----MQT------QPSM 440

  Fly   402 LPEAVKEEETGGEVPSDGGEGAVEAAPVPAKRRKAVHKMNMNFYGAGGVESTKSEEPSQERTPLF 466
            ....:|.                                       |.||:.|:|       ||.
Frog   441 QSFDIKN---------------------------------------GKVETVKNE-------PLG 459

  Fly   467 -KYEPGLIVECSLLKPCTNVKEFKAEMRQYPDIKYVDIKEGDQVALLRLGTPAAAEELLRQVNCS 530
             ::..|:|.:.:...|....|..|.......::.|||:.|||....:|..:|..|:..::  ..|
Frog   460 PQFVCGVIGKITSSDPLQGRKYVKDAFSGVCEVVYVDMLEGDTECHVRFKSPEDAQTAVK--TRS 522

  Fly   531 ERQ------LKVLSGQQETLYWRKIEQDREAKLSKKVRVQQKRGREKV----GKM-------LGK 578
            :.|      |::|:|..|..||:||..||:|||::.  .::|||.||:    .||       ..|
Frog   523 DLQGKHNWKLQILAGDNEQRYWQKILVDRQAKLNRP--REKKRGTEKLIAKAEKMRLAKTQEASK 585

  Fly   579 HIKFDDG 585
            ||:|.||
Frog   586 HIRFSDG 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp7	NP_524795.2	LA	57..135	CDD:128955	31/79 (39%)
		RRM	<116..>208	CDD:223796	44/113 (39%)
		RRM1_LARP7	148..>209	CDD:240736	34/81 (42%)
		RRM2_LARP7	471..548	CDD:240986	22/82 (27%)
larp7	NP_001039168.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		6/24 (25%)
		LARP_7	32..113	CDD:153401	32/80 (40%)
		RRM1_LARP7	128..207	CDD:240736	32/78 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..363		32/177 (18%)
		RRM2_LARP7	465..546	CDD:240986	22/82 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9695
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3726
OMA	1	1.010	-	-		QHG47085
OrthoDB	1	1.010	-	-		D1499213at2759
OrthoFinder	1	1.000	-	-		FOG0007459
OrthoInspector	1	1.000	-	-		oto104988
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R649
SonicParanoid	1	1.000	-	-		X6335
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110