DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp7 and LARP7

DIOPT Version :9

Sequence 1:	NP_524795.2	Gene:	Larp7 / 44900	FlyBaseID:	FBgn0260771	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_001357903.1	Gene:	LARP7 / 51574	HGNCID:	24912	Length:	595	Species:	Homo sapiens

Alignment Length:	647	Identity:	175/647 - (27%)
Similarity:	285/647 - (44%)	Gaps:	148/647 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EENSKEPAPEDASPDKKDGGRKRKR----HLFNSIRGQMEFYFGDANLSKDRFLRRYVE--QDPY 91
            |..::|...|:.|.:||....|:||    .:...|..|::|:||||||.||||||..:|  :|.|
Human     4 ESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGY 68

  Fly    92 VPLEIFLTFNKIKTLTQDVQQIAKALSNSQLLELDETELKVKRRTKLPDQ-RDVNDKTLYVEALP 155
            |.:.:.::|||:|.||.|.:.||:||.:|.::|||....:::|:..|.:: :|.:::|:|||.||
Human    69 VDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPKDEDERTVYVELLP 133

  Fly   156 ANATHDWLKEVFSRYGPVAYVSLPHYPGTKKIKEFAFIEFE---------------------KSG 199
            .|..|.|::.||.:.|.|.|:|:|||..|...|.|||:|||                     |.|
Human   134 KNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPG 198

  Fly   200 SLEKAVKAFAQIQGVLSVETDPSDLASVRSFQQQQQIQQKAE---------------QPQSEAEQ 249
            ...|.||. ..|..:..||............:::..||.|.|               :|.||...
Human   199 IFPKTVKN-KPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSD 262

  Fly   250 VEL--PKRNLKREATDKDREEIHEVKRVKLEEGQPSETSTAG-----------------ETASET 295
            :|.  |::...::...:||.|...:..|:..:.:.|.:..|.                 :.|||.
Human   263 IESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEA 327

  Fly   296 DAEGTA--------------EASEQEDKTEATDGDEAAKKRRRKRKKKAIVDKPNIEPSALELKV 346
            ..|..|              |.|.:|:|......|.:..|.:||.|||. .::..:....:.|:|
Human   328 SKENRAPCLNGELFYLFQDIEISTEEEKDTGDLKDSSLLKTKRKHKKKH-KERHKMGEEVIPLRV 391

  Fly   347 LPKTSWSSMRNKYLNLQRRIVSEAKSKLWRENHPQNQQHPHHQQTSHPNHPKPSQLPEAVKEEET 411
            |.|:.|..::.:||.||:..::..|..:                         ||: ::..|.||
Human   392 LSKSEWMDLKKEYLALQKASMASLKKTI-------------------------SQI-KSESEMET 430

  Fly   412 GGEVPSDGGEGAVEAAPVPAKRRKAVHKMNMNFYGAGGVESTKSEEPSQERTPLFKYEPGLIVEC 476
            ...||.:.|          .|..|..::           |..:::|......|  ::..|:||:.
Human   431 DSGVPQNTG----------MKNEKTANR-----------EECRTQEKVNATGP--QFVSGVIVKI 472

  Fly   477 SLLKPCTNVKEFKAEMRQYPDIKYVDIKEGDQVALLRLGTPAAAEELLR---QVN---CSERQLK 535
            ...:|....|:.:..:....::.|||:.|||.....|..||..|:.::.   ::|   |  .:|:
Human   473 ISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHC--WKLE 535

  Fly   536 VLSGQQETLYWRKIEQDREAKLSKKVRVQQKRGREKV-----------GKMLGKHIKFDDGD 586
            :|||..|..||:||..||:|||::.  .::|||.||:           .:...|||:|.:.|
Human   536 ILSGDHEQRYWQKILVDRQAKLNQP--REKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp7	NP_524795.2	LA	57..135	CDD:128955	35/83 (42%)
		RRM	<116..>208	CDD:223796	40/113 (35%)
		RRM1_LARP7	148..>209	CDD:240736	31/81 (38%)
		RRM2_LARP7	471..548	CDD:240986	24/82 (29%)
LARP7	NP_001357903.1	LARP_7	30..111	CDD:153401	34/80 (43%)
		RRM	<117..300	CDD:223796	49/183 (27%)
		RRM1_LARP7	126..205	CDD:240736	29/78 (37%)
		RRM_3	467..565	CDD:370115	31/101 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160525
Domainoid	1	1.000	64	1.000	Domainoid score	I10155
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3744
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47085
OrthoDB	1	1.010	-	-		D1499213at2759
OrthoFinder	1	1.000	-	-		FOG0007459
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105632
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R649
SonicParanoid	1	1.000	-	-		X6335
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.900