DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp7 and Larp4B

DIOPT Version :9

Sequence 1:	NP_524795.2	Gene:	Larp7 / 44900	FlyBaseID:	FBgn0260771	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster

Alignment Length:	607	Identity:	113/607 - (18%)
Similarity:	200/607 - (32%)	Gaps:	223/607 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PDPAAPTEPAEENSKEPA----PEDASPDKKDGGR-------------KRKRHLFNSIRGQMEFY 70
            |.|.....|.:...:.|.    |.:.|.|.:.|..             |.|:.|..    |:|:|
  Fly   219 PQPHQIVVPVQVPVQVPVPVQLPANGSADPQQGSHNAAGGEEPNIPLDKLKQMLAT----QLEYY 279

  Fly    71 FGDANLSKDRFLRRYVEQDPYVPLEIFLTFNKIKTLTQDVQQIAKALSNSQLLELDETELKVKRR 135
            |...||:.|.:|...::.|.|||:.....||.::.||.|:..|.:.|..|..:::|:..|:|:
  Fly   280 FSRENLANDTYLLSQMDSDQYVPIYTVARFNLVRKLTNDINLITEVLRESPNVQVDDKGLRVR-- 342

  Fly   136 TKLPDQRDVNDKTLYVEALPANATHDWLKEVFSRYGPVAYVSLPHYPGTKKIKEFA-----FIEF 195
               |:::..   .:.:..:..|...|.:|.:||.......:|.          |||     :|.|
  Fly   343 ---PNRKRC---IIILREISNNTPLDDVKALFSNESCPRPISC----------EFAANNSWYITF 391

  Fly   196 EKSGSLEKAVKAFAQIQGVLSVETDPSDLASVRSFQQQQQIQQKAEQPQSEAEQVE-LPKRNLKR 259
            |.....:||.|...:               .|:.||.:..:.:  .:|:|...::: :||...:
  Fly   392 ESDEDAQKAYKYLRE---------------EVKEFQGKPIMAR--IKPKSFINRIQAVPKNGYR- 438

  Fly   260 EATDKDREEIHEVKRVKLEEGQPSETSTAGETASETDAEG-----TAEASEQEDKTEATDGDEAA 319
                                      .|:..||:..|..|     .:.|:.|:.:...|:|...|
  Fly   439 --------------------------LTSPPTANVFDPAGAGGATVSYAAAQQPRYLYTNGAAIA 477

  Fly   320 KKRRRKRKKKAIVDKPNIEPSALELK---VLPKTSWSSMRNKYLNLQRRIVSEAKSKLWRENHPQ 381
                              .|::::..   ::|                              .||
  Fly   478 ------------------APASVQYSNPVLIP------------------------------IPQ 494

  Fly   382 NQQHP-----------------HHQQ---------TSHPNHPKPSQLPEAVKEEETGG--EVPSD 418
            ||.:|                 |.|.         |::|..|:|          .|.|  :.|..
  Fly   495 NQFYPGLVAGPWPPGTVAATTAHGQNFYELGGNIFTTNPLPPQP----------VTAGFAQAPPP 549

  Fly   419 GGEGAVEAAPVPAKRRKAVHKMNMNFYGAGGVES-----TKSEEPSQERTPLFKY-EPGLIVECS 477
            ..:..|...|....|....|:.|.|  ..||..|     ::|:.|  ..||...: :.|.|:...
  Fly   550 TSQAMVTPKPQGGGRYNNNHRGNPN--NVGGANSGPRAESRSKPP--RSTPSASHIQGGNIMPIQ 610

  Fly   478 LLKPC---------TNVKE---FKAEMRQYPDIKYVDIKEGDQVALLRLGTPAAAEELLR----Q 526
            :..|.         ||:.:   ..|.::|.|......|::          .|:::.:..:    |
  Fly   611 ITAPIPGGMVSVVPTNIVQDPLQPAPLQQQPQQVIQQIQQ----------QPSSSAQQQQAATVQ 665

  Fly   527 VNCSERQLKVLS----GQQETL 544
            :|.:.|...:.|    |.|:.|
  Fly   666 MNNTTRHYPIKSNWKGGMQKNL 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp7	NP_524795.2	LA	57..135	CDD:128955	24/77 (31%)
		RRM	<116..>208	CDD:223796	21/96 (22%)
		RRM1_LARP7	148..>209	CDD:240736	15/65 (23%)
		RRM2_LARP7	471..548	CDD:240986	17/94 (18%)
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	25/82 (30%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	18/104 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456176
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940