DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Larp7 and La

DIOPT Version :9

Sequence 1:	NP_524795.2	Gene:	Larp7 / 44900	FlyBaseID:	FBgn0260771	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_477014.1	Gene:	La / 35305	FlyBaseID:	FBgn0011638	Length:	390	Species:	Drosophila melanogaster

Alignment Length:	424	Identity:	108/424 - (25%)
Similarity:	191/424 - (45%)	Gaps:	97/424 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ATSAEKPDPAAPTE---PAE---------ENSKEPAPEDASPDKKDGGRKRKRHLFNSIRGQMEF 69
            |..||.|...|..|   |||         :..|:|||  |:.:...|..|::|    :|..|:|:
  Fly     2 AEVAETPSVEAQEEVAQPAEAQVLEAKNGDAKKDPAP--AAEEAAGGFTKQER----AIIRQVEY 60

  Fly    70 YFGDANLSKDRFLRRYV--EQDPYVPLEIFLTFNKIKTLTQDVQQIAKALSNSQ--LLELDETEL 130
            |||||||::|:|||..:  .:|.:|||.:.:||.::.:|:.|:.:|..||:.|:  |:|:.|.:|
  Fly    61 YFGDANLNRDKFLREQIGKNEDGWVPLSVLVTFKRLASLSTDLSEIVAALNKSEEGLVEISEDKL 125

  Fly   131 KVKRRTKLP-------DQRDVNDKTLYVEALPANATHDWLKEVFSRYGPVAYVSL-PHY-PGTK- 185
            .::|..:.|       .::::.::|.|.:..|.::....|.:..:.|..|..::: .|| ..||
  Fly   126 SLRRHPERPIPEHNEERRKEIQERTAYAKGFPLDSQISELLDFAANYDKVVNLTMRKHYDKPTKS 190

  Fly   186 -KIKEFAFIEFEKSGSLEKAVKAFAQIQGVLSVETDPSDLASVRSFQ------QQQQIQQKAEQP 243
             |.|...|:.||    .:...|||.:.:.::..|.:     .:|.:|      :|::..||.|:.
  Fly   191 YKFKGSIFLTFE----TKDQAKAFLEQEKIVYKERE-----LLRKWQVDYLKEKQEEYAQKNEKR 246

  Fly   244 QSEAE-----QVELPK--------------RNLKREATDKDREEIHEVKRVKLEEGQPSETSTAG 289
            :::.|     ..||||              |...|||.:|.::  .||..::..:|:     |.|
  Fly   247 KNKKEAKPEPAFELPKNAIVVFEGAPETSSREEIREAFEKIKD--FEVAYIEFAKGE-----TKG 304

  Fly   290 ET-ASETDAEGTAEASEQEDKTEATDGDEAAKKRRRKRKKKAIVDKPNIEPSALELKVLPKTSWS 353
            .. .:|.||.....|..:|.|.:..|....:.::..:.::|..:||      |:|.
  Fly   305 SVRLTEADAAEKYIAKVEEGKLKFKDEVSLSLRKATEEEEKEFIDK------AIEF--------- 354

  Fly   354 SMRNKYLNLQRRIVSEAKSKLWRENHPQNQQHPH 387
             |:      :||..:..|.|.:.........|.|
  Fly   355 -MK------KRRDFTRNKGKRFNRKRHGGNDHKH 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp7	NP_524795.2	LA	57..135	CDD:128955	31/81 (38%)
		RRM	<116..>208	CDD:223796	25/104 (24%)
		RRM1_LARP7	148..>209	CDD:240736	17/64 (27%)
		RRM2_LARP7	471..548	CDD:240986
La	NP_477014.1	LARP_3	47..129	CDD:153397	32/85 (38%)
		RRM1_La	150..226	CDD:240737	19/84 (23%)
		RRM_SF	263..338	CDD:302621	17/81 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456177
Domainoid	1	1.000	51	1.000	Domainoid score	I3340
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46772
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R649
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.970