DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Larp7 and sla1

DIOPT Version :9

Sequence 1:	NP_524795.2	Gene:	Larp7 / 44900	FlyBaseID:	FBgn0260771	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_593315.1	Gene:	sla1 / 2541530	PomBaseID:	SPAC57A10.10c	Length:	298	Species:	Schizosaccharomyces pombe

Alignment Length:	324	Identity:	82/324 - (25%)
Similarity:	145/324 - (44%)	Gaps:	50/324 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SIEKEKGE------GQEPATSAEKPDPAAP-TEPAEENSKEPAPEDASPDKKDGGRKRKRHLFNS 62
            |.|::|.|      .||.::...|.:.|.. .|..::.:.|...|:.:..|:|.|:|........
pombe     2 STEEQKEEIKDISSKQENSSEVPKAEEAGKVVESQKDTTSEEKKEETTEKKEDDGKKDLSFDEAE 66

  Fly    63 IRGQMEFYFGDANLSKDRFL-RRYVEQDPYVPLEIFLTFNKIKTLTQDVQQIAKALSNS-QLLEL 125
            :..|:||||.|.||..|:|| ....:.|.:||::....|.:::.. |.::.|..||..| :|||:
pombe    67 VLKQVEFYFSDTNLPHDKFLWTTSQKNDGWVPIQTIANFKRMRRF-QPLEAIVNALRKSPELLEV 130

  Fly   126 DETELKVKRRTKL--PDQRDVNDKTLYVEAL--PANATHDWLKEVF-SRYGPVAYVSLPHYPGTK 185
            ||...||:|...|  .|.:.|.::::|.:..  ..:.|...|::.| ...||::.|.: .....|
pombe   131 DEAGEKVRRMIPLVRVDNKSVMERSVYCKGFGDEKDDTQIALEKFFEENAGPISAVRM-RRDDDK 194

  Fly   186 KIKEFAFIEFEKSGSLEKAVKAFAQIQGVLSVETDP----SDLASVRSFQQQQQIQQKAEQPQSE 246
            |.|...|:||::.....|.::         .|:|.|    .|..::.|  :::.:..|||..:::
pombe   195 KFKGSVFVEFKEPDVANKFLE---------KVKTAPLKWGEDELTIMS--KKEYVDMKAELHKND 248

  Fly   247 AEQVELPKRNLKREATDKDREEIHEVKRVKLEEGQPSETSTAG-----ETASETDAEGTAEASE 305
            .     ||.:.||...|..:|         ::..:|.:.|..|     :.:|....|..:.|||
pombe   249 P-----PKFSSKRRRFDAFKE---------MDRQRPGKYSNRGRKFKKQRSSNASEEKPSAASE 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp7	NP_524795.2	LA	57..135	CDD:128955	27/79 (34%)
		RRM	<116..>208	CDD:223796	28/97 (29%)
		RRM1_LARP7	148..>209	CDD:240736	14/63 (22%)
		RRM2_LARP7	471..548	CDD:240986
sla1	NP_593315.1	LHP1	1..298	CDD:227520	80/322 (25%)
		LA_like_fungal	64..139	CDD:153398	27/75 (36%)
		RRM1_La	155..232	CDD:240737	18/86 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	51	1.000	Domainoid score	I3340
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R649
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.990