DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-d and SFMBT2

DIOPT Version :9

Sequence 1:	NP_524794.2	Gene:	ph-d / 44889	FlyBaseID:	FBgn0004860	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_001018049.1	Gene:	SFMBT2 / 57713	HGNCID:	20256	Length:	894	Species:	Homo sapiens

Alignment Length:	486	Identity:	112/486 - (23%)
Similarity:	158/486 - (32%)	Gaps:	171/486 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1139 STPSKGATTPTSKQSNAAVQPPSSTIPNSVSGKEEPKLTTCGSLTSATSTSTTTTITNGIGVART 1203
            :.|.|   |.:.|:...||..|...:|.:|..|:.|. ..|
Human   475 TAPHK---TVSQKKRKIAVVQPEKQLPPTVPVKKIPH-DLC------------------------ 511

  Fly  1204 TASTAVSTASTTTTSSGTF-------TTSCTSTTTTTTSSISNGSKDLPKAMIKPN----VLTHV 1257
                ......||.|.:|.:       ...|.|........|:    :||:: :.|.    ||..|
Human   512 ----LFPHLDTTGTVNGKYCCPQLFINHRCFSGPYLNKGRIA----ELPQS-VGPGKCVLVLKEV 567

  Fly  1258 IDGFIIQEANEPFPVTRQRYADKD----VSDEPPKKK---ATMQEDIKLSGIASAPGSDMVA--C 1313
            : ..||..|.:|..|.|:....:|    ..:|..|.|   .|.:..:|:     ...||.||  |
Human   568 L-SMIINAAYKPGRVLRELQLVEDPHWNFQEETLKAKYRGKTYRAVVKI-----VRTSDQVANFC 626

  Fly  1314 EQ-CGKME---------------------H-KAKL-----KRKRYCSPGCSR------------- 1337
            .: |.|:|                     | |.|.     |||:...|....
Human   627 RRVCAKLECCPNLFSPVLISENCPENCSIHTKTKYTYYYGKRKKISKPPIGESNPDSGHPKPARR 691

  Fly  1338 ---------QAKNGIGGV----GSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTESYQTVS 1389
                     |.|.....|    ||||.:       ...||    |.:|:..|.|:..:|.....:
Human   692 RKRRKSIFVQKKRRSSAVDFTAGSGEES-------EEEDA----DAMDDDTASEETGSELRDDQT 745

  Fly  1390 DALPIQAATPEVPPISMPVLAAMSTSSPLSLPLTLPLPIAIAPTVSLPVVSAGVVAPVLAIPSSN 1454
            |     .::.|||. :.|..|....|.  |.|:..|.|         .....|..||.   .||.
Human   746 D-----TSSAEVPS-ARPRRAVTLRSG--SEPVRRPPP---------ERTRRGRGAPA---ASSA 790

  Fly  1455 INGSDRPPIS----------------------SWSVEEVSNFIRELPGCQDYVDDFIQQEIDGQA 1497
            ..|...||..                      .|:|.:|..||: |..|......|.:|:|||||
Human   791 EEGEKCPPTKPEGTEDTKQEEEERLVLESNPLEWTVTDVVRFIK-LTDCAPLAKIFQEQDIDGQA 854

  Fly  1498 LLLLKENHLVNAMGMKLGPALKIVAKVESIK 1528
            ||||....:...|.:|||||:|:..::|.:|
Human   855 LLLLTLPTVQECMELKLGPAIKLCHQIERVK 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976	29/90 (32%)
ph-d	NP_524794.2	SAM	1464..1529	CDD:197735	27/87 (31%)
SFMBT2	NP_001018049.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		MBT 1	44..144
		MBT	48..144	CDD:214723
		MBT 2	152..256
		MBT	156..256	CDD:214723
		MBT 3	266..372
		MBT	276..372	CDD:214723
		MBT 4	380..477		0/1 (0%)
		MBT	384..477	CDD:214723	0/1 (0%)
		SLED	528..643	CDD:403384	29/125 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..813		34/171 (20%)
		SAM_Scm-like-4MBT1,2	810..894	CDD:188980	27/77 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8350
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860