DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-d and samd11

DIOPT Version :9

Sequence 1:	NP_524794.2	Gene:	ph-d / 44889	FlyBaseID:	FBgn0004860	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	XP_009295182.1	Gene:	samd11 / 569122	ZFINID:	ZDB-GENE-060428-2	Length:	874	Species:	Danio rerio

Alignment Length:	704	Identity:	154/704 - (21%)
Similarity:	236/704 - (33%)	Gaps:	229/704 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   885 QQQQQPQQQS-GQLQLSSVPFSVSPSMTAEDIAGITSSALQEALSVSGAIFQTTKPITCSSSTLP 948
            :|...|:.|| ..|.|:|.        ..:||.|     .:.|.|.:            |||..|
Zfish   257 RQHGMPEGQSCSDLSLASA--------HTDDILG-----KRRAYSPN------------SSSECP 296

  Fly   949 TSSVVTITSQSSTPLVTSSTVASMQQAQTQGTQIHQHQQLISATIAGGSQQQQQQQ------QLG 1007
            :.|.   .|:|.:|...|.|.|  .:..:..|....:::::||....||.::|||:      .:|
Zfish   297 SDSK---KSRSVSPKENSHTPA--LEPGSHMTPEEHYRRMMSALNEHGSYEEQQQRLYQLANNMG 356

  Fly  1008 LPSLTPTTPSPTTNPILAMTSMMNATVGHLSTAPPVSVSS----TAVTPSSGQLVTLSSASSGGG 1068
            :||          :.:|           |:.....|:|.:    .|..||:|     ||:|....
Zfish   357 IPS----------HELL-----------HVRQEAMVAVRNPGGMEAHVPSAG-----SSSSQRRK 395

  Fly  1069 AGFPATPTKETPSKG---PTATLVPIDSP--------KTPVSGKDT--CTTPKSS--TPATVS-- 1116
            .|.|.......|.:.   |...|.|.::|        :.|..|..:  |..|...  .||...
Zfish   396 QGLPQHRDAHFPERDISHPPPLLSPQNAPHIALGPHLRPPFLGMPSALCQAPGYGFLQPAQAEMF 460

  Fly  1117 ------------ASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPS----STIP 1165
                        |.:|.|:   |.|...:..:...  .:....|.........:.|:    ..||
Zfish   461 ARQQEILRKQNLARLEMSA---ELLRQKELENLHR--QRLLADPLGLHPGLPAEHPALRSLQEIP 520

  Fly  1166 NSVSGKEEPKLTTCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFTTSCTSTT 1230
            .....:||  |....::......:|.....|..|.|..|:|..:|...:.....
Zfish   521 EGHPLREE--LNRRNAMLVLRHNNTPLLSLNHQGAAAGTSSKDLSNRKSLRKGG----------- 572

  Fly  1231 TTTTSSISNGSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKATMQE 1295
              .......|.....|.|::        :|.:                 :||..|      .|.|
Zfish   573 --PLQGDQQGGSSETKEMLR--------EGCV-----------------RDVETE------GMDE 604

  Fly  1296 DIKLSGIASAPGSDMVACEQCGKMEHKAKLKRKRYCSPGCSRQAKNGIGGVGSGETNGLGTGGIV 1360
            |:|.|...:..|.|        :.|..:|                        |:.:||.:....
Zfish   605 DMKDSENDAEVGED--------RPERLSK------------------------GDGHGLSSEVCQ 637

  Fly  1361 GVDAMALVDRLDEAMAE--------------EKMQTESYQTVSDALPIQAA---TPEVPPISMPV 1408
            |.|    |.:..||:.|              ...::.::...:..|....|   .|.:||  :|.
Zfish   638 GKD----VTKTSEAIKELGEGSGRLSVPCSSTGQESPTHHLFTSGLGKNEAKYLPPGIPP--LPT 696

  Fly  1409 LAAMSTSSPLSLPLTLPLPIAIAPTVSLPVVSAGVVAPVLAIPSSNINGSD---RPPISSWSVEE 1470
            |...      .||.|.|        .|.|....|.:..:.      ::|.:   ...||.|||||
Zfish   697 LPGQ------MLPFTFP--------YSSPYFHTGAMGGLF------VDGEEAGAAEDISKWSVEE 741

  Fly  1471 VSNFIRELPGCQDYVDDFIQQEIDGQALLLLKENHLVNAMGMKLGPALKIVAKV 1524
            |.:||..|.||.:|...|.:|.|||:.|.||.|:||:|.||:||||||||.::|
Zfish   742 VCSFISSLAGCGEYTQVFREQAIDGETLPLLTEDHLLNNMGLKLGPALKIRSQV 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976	37/64 (58%)
ph-d	NP_524794.2	SAM	1464..1529	CDD:197735	36/61 (59%)
samd11	XP_009295182.1	SAND	93..165	CDD:279658
		SAM_Samd7,11	734..801	CDD:188978	37/62 (60%)
		SAM	735..791	CDD:197735	33/55 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010