DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ph-d and Phc2

DIOPT Version :9

Sequence 1:NP_524794.2 Gene:ph-d / 44889 FlyBaseID:FBgn0004860 Length:1537 Species:Drosophila melanogaster
Sequence 2:NP_001182059.1 Gene:Phc2 / 54383 MGIID:1860454 Length:850 Species:Mus musculus


Alignment Length:987 Identity:254/987 - (25%)
Similarity:380/987 - (38%) Gaps:278/987 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   677 VVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQQQQLQLF------QKQHILQQQMLQQQ 735
            |.:.:....|..:|:||..:.....:......:|......|:.::      |...::||.:.:|.
Mouse     7 VPHTSNRASVTTNTSGTNSSSGCISSSGGGGGSGGRPTAPQISVYSGIPDRQTVQVIQQALHRQP 71

  Fly   736 IAAIQMQQQQAAVQAQQQQQQQVS-QQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQV-AQAQA 798
            ..|.|..||..|.|.|....|..: |||.:::.|.|::|..|||...|.:|.......| :||.|
Mouse    72 STAAQYLQQMYAAQQQHLMLQTAALQQQHLSSAQLQSLAAVQQASLVANRQGSTPGSSVSSQAPA 136

  Fly   799 QHQQ---ALANATQQILQVAP--NQFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQAQQ 858
            |...   |.:.|..|::..|.  |....|...||...|.|.........|||..::||:      
Mouse   137 QSSSLNLAASPAAAQLINRAQSVNSAAASGLAQQAVLLGNTSSPALTASQAQMYLRAQM------ 195

  Fly   859 QQQQREQQQNIIQQIVVQQSTGATSQQQQQQPQQQSGQLQLSSVPFSVSPSM--TAEDIAGITSS 921
                         .|....:|.||     .||:..:|           ||:.  |...:..:|..
Mouse   196 -------------LIFTPTATVAT-----VQPELCTG-----------SPARPPTPAQVQNLTLR 231

  Fly   922 ALQ-EALSVSGAIFQTTKPITCSSSTLPTSSVVTITSQSSTPLVTSSTVASMQQ-----AQTQGT 980
            ..| .|.:.||.  ..|:|:..|.:..||.|       ||.||.......:|.|     |:..||
Mouse   232 TQQTPAAAASGP--PPTQPVLPSLALKPTPS-------SSQPLPAPPQGRTMAQGSPAGAKPSGT 287

  Fly   981 Q--------------------------------------IH-QHQQLISATIAGGSQQQ---QQQ 1003
            .                                      .| |..||:....|...|.|   |||
Mouse   288 DNAPETLKAGDGNCNMEGRPGPGRAVPAVATHPLIAPAYAHLQSHQLLPQPPAKHPQPQFVAQQQ 352

  Fly  1004 QQLGLPSLTPTTPSP---------TTNPILAMTSMMN---ATVGHLSTAPPVSVSSTAV-TPSSG 1055
            .|       |..|:|         :.:|.||:.|...   ..:|.::.|.|:..|:|.| .|.:.
Mouse   353 PQ-------PPRPAPQVQSQPQLASVSPSLALQSSPEDHALPLGSVTQALPLQCSTTHVHKPGNS 410

  Fly  1056 QLVTLSSASSGGGAGFPATPTKETPSKGP------TATLVPIDSPKTPVSGKDTCTTPKSSTPAT 1114
            |...|.:..:|...|.|     |..|..|      |:.::....|.:||       ||:...|..
Mouse   411 QQCHLPTLDTGSQNGHP-----EGGSHPPQRRFQHTSAVILQVQPASPV-------TPQQCAPDD 463

  Fly  1115 VSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSSTIPNSVSGKEEPKLTTC 1179
            ....|.|..|...|                  .|.......|:.|   .||..:.|.:.|.:..|
Mouse   464 WKEVVPAEKSVPVA------------------RPGPSPHQQAIIP---AIPGGLPGPKSPNIQQC 507

  Fly  1180 GSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFTTSCTSTTTTTTSSISNGSKDL 1244
                .|..|        |.|:..         |.|..:|.|..:.:..|.::...::..||....
Mouse   508 ----PAHET--------GQGIVH---------ALTDLSSPGMTSGNGNSASSIAGTAPQNGENKP 551

  Fly  1245 PKAMIKPNVLTHVIDGFIIQEANEPFPVTR---------QRYADKDVSDEPPKKKATMQEDIKLS 1300
            |:|::||.:|||||:||:|||..|||||.|         ::||...:.::||::..|...|.::.
Mouse   552 PQAIVKPQILTHVIEGFVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKPPQQDHTTTTDSEME 616

  Fly  1301 ----GIASAPGSDM-VACEQCGKMEHKAKLKR-KRYCSPGCSRQAKNGIGGVGSGETNGLGTGGI 1359
                ..:...|:.: :.||.||:::...|.|| ||:||..|:::.     .||..:..||...  
Mouse   617 EPYLQESKEEGTPLKLKCELCGRVDFAYKFKRSKRFCSMACAKRY-----NVGCTKRVGLFHS-- 674

  Fly  1360 VGVDAMALVDRLDEAMAEEKMQ-----TESYQTVSDA-LP-IQAATPEVPPISMP--VLAAM--- 1412
                     ||       .|:|     |.:.:..|.| || :...|.:.|..::|  |.||:   
Mouse   675 ---------DR-------SKLQKAGTTTHNRRRASKASLPTLTKDTKKQPSGTVPLSVTAALQLA 723

  Fly  1413 ---------STSSPLSLPLTLPLPIAIAPTVS----------LP------VVSAGVVAPVLAIPS 1452
                     |.:|....||:   ||:.:.:.|          ||      :|..|    ...:||
Mouse   724 HSQEDSSRCSDNSSYEEPLS---PISASSSTSRRRQGQRDLDLPDMHMRDLVGVG----HHFLPS 781

  Fly  1453 SNINGSDRPPISSWSVEEVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKENHLVNAMGMKLGPA 1517
            ..         :.|:||:|..|||.|||||:..::|..|||||||||||||:||::||.:|||||
Mouse   782 EP---------TKWNVEDVYEFIRSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPA 837

  Fly  1518 LKIVAKVESIKE 1529
            |||.|::..:|:
Mouse   838 LKIYARISMLKD 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ph-dNP_524794.2 SAM_Ph1,2,3 1461..1529 CDD:188976 39/67 (58%)
SAM 1464..1529 CDD:197735 39/64 (61%)
Phc2NP_001182059.1 Disordered. /evidence=ECO:0000269|PubMed:27827373 1..79 13/71 (18%)
Interaction with BMI1. /evidence=ECO:0000269|PubMed:27827373 33..56 2/22 (9%)
PHA03247 <216..540 CDD:223021 83/393 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 233..314 19/89 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..386 14/57 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 402..436 11/38 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 528..553 3/24 (13%)
HD1 550..579 17/28 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..624 4/26 (15%)
PHC2_SAM_assoc 662..780 CDD:374673 30/142 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 676..712 10/42 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 725..764 7/41 (17%)
SAM_Ph1,2,3 781..849 CDD:188976 40/76 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 91 1.000 Domainoid score I7659
eggNOG 1 0.900 - - E1_28JS2
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8777
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12247
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5858
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
98.900

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