DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-d and phc1

DIOPT Version :9

Sequence 1:	NP_524794.2	Gene:	ph-d / 44889	FlyBaseID:	FBgn0004860	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	XP_005158395.1	Gene:	phc1 / 403008	ZFINID:	ZDB-GENE-081022-39	Length:	901	Species:	Danio rerio

Alignment Length:	1093	Identity:	271/1093 - (24%)
Similarity:	405/1093 - (37%)	Gaps:	286/1093 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 NQPDGTQGMFIQQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQQVGTTNQTQQ 573
            ::|.....|.:.::.|.|.||..|.|                     |...|..||:     ..|
Zfish    23 SRPPQIAQMSLYERQAVQALQALQRQ---------------------PNAAQYFQQL-----MLQ 61

  Fly   574 QQLAVATAQLQQ--QQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKA--KMRNK 634
            ||:..||.||..  ..||.|.||.::..:|    |.:..:|.|  |.|...|.|...|  .|.|
Zfish    62 QQINSATCQLHNLAAVQQATLAASRQSSSP----NNSASQPTS--SAQCTVNLSTTSAGGTMTN- 119

  Fly   635 QQPVRPALATLKTEIGQ--VAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITL 697
            .:|:.||.:...|.:.|  :.|.|       :..|.|....:.:.:.|.....::....||
Zfish   120 PRPIGPATSAASTALSQSVLLGGN-------SGGQGQMYLRVNRSLRAPLTPQLIFMPGGT---- 173

  Fly   698 QNGQTLHAATAAGVDKQQQQLQLFQKQHILQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQ 762
               .|...||.|....|||           .||..|||      |||:|...:...|    |...
Zfish   174 ---ATATVATVAQTQPQQQ-----------PQQQPQQQ------QQQEATPTSSSSQ----SDND 214

  Fly   763 QVNAQQQQAVAQQQQAVAQAQQQQREQQQQVAQAQAQHQQALANATQQILQVAPNQFITSHQQQQ 827
            ||.....:.|:..:.|..:.:...|::.........|.|             .|.||..|.||
Zfish   215 QVQNLAMRCVSTPRAATVKTEFADRKETTGTFPLNQQTQ-------------TPQQFGQSTQQ-- 264

  Fly   828 QQQLHNQLIQQQLQQQAQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQSTGATSQQQQQQPQQ 892
                    :|.|.|..|.|::|:..............:..|  |..|..|..||:|......|
Zfish   265 --------VQPQTQPLANAKLQSFSNTANPSVPALNVKPTN--QSAVAPQQAGASSNPPSSSP-- 317

  Fly   893 QSGQLQLSSVPFSVSPSMTAEDIAGITSSALQEALSVSGAIFQTTKPITCSSSTLPTSSVVTITS 957
                          :||:....:. ::.|.|.:...|.|:      ..|.:...:|||:|.  ||
Zfish   318 --------------TPSLPLSQLL-LSQSGLHQTRGVPGS------TATVTHILVPTSNVP--TS 359

  Fly   958 QSSTPLVTSSTVASMQQAQTQGTQIHQH--QQLISATIAGG----------SQQQQQQQQLGLPS 1010
            ....||.|.:|.::| .|||...|..|.  ..|.:..:|.|          :|..:...|:....
Zfish   360 TQGYPLGTVATKSNM-TAQTLVVQPLQQTGANLSTEKLAHGTGHVPIQPKTAQGHRVPVQMSPRH 423

  Fly  1011 LTPTTPSPTTN------------PILAMTSMMNATVGHLSTAPPVSVSSTAVTP----------S 1053
            ..|..|:|..|            |: .:.....:|:|: |.|..::.:.|..:.          :
Zfish   424 PPPILPAPPNNGQATAGLHPPHVPV-QLVGARQSTLGN-SQALALAQARTCCSQQDGTAAVGVNN 486

  Fly  1054 SGQLVTLSSASSGGGAGFPATPTKETPSKGPTATLVPIDSPKTPVSGKDTCTTPKSSTPATVSAS 1118
            .|.:||:.:|....|||......:         :.:||...:|..|     .......||:|:.|
Zfish   487 PGNVVTMVTAMDTSGAGMCLKTAQ---------SALPISQMQTNQS-----AVLSQGNPASVTHS 537

  Fly  1119 VEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSSTIPNSVSGKEEPKL-TTCGSL 1182
            ::..:::|::|....|    ....|.|..|..::|.:.:....|..|  :||  .|.: .:...|
Zfish   538 MDGQNNSGDSLFVQSA----QAQIKPAIGPIKRKSESDLTHEISNEP--ISG--SPSMQDSAPPL 594

  Fly  1183 TSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFTTSCTSTTTTTTSSISNGSK-DLPK 1246
            :.|.|..|...|             |.|:..|.:          .|...........|.: .:|:
Zfish   595 SPAPSLDTVPEI-------------AFSSPPTLS----------LSLPLPLPRGAGQGDRAPVPQ 636

  Fly  1247 AMIKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKATMQEDIKLSGIASAPGSDMV 1311
            |::||.||||:|:||:|||..||||||...   |::|...|  .....|||:         ||.:
Zfish   637 AVVKPQVLTHLIEGFVIQEGAEPFPVTGPL---KELSGAVP--PILHPEDIR---------SDKL 687

  Fly  1312 ACEQCGKMEHKAKLKR-KRYCSPGCSR----------QAKNGIGGVGSGETNGLGTGGIVGVDAM 1365
            .||.|......::.:| ||:|:..||:          :|..|:.|...      ..||.|..|.:
Zfish   688 KCEYCLNFAPASQFRRSKRFCTISCSKRYNVSFRNHLRASRGLEGAER------PAGGPVVQDVI 746

  Fly  1366 ALVDRLDEAMAEE-------------KMQTESYQTVSDALPIQAATPEVPPISMPVLAAMSTSSP 1417
            |. .|.....:.|             |.::||.:  ||.:.......|...:|      :|.||.
Zfish   747 AR-RRAPRRSSSEIACAKITGRHLPVKCRSESSR--SDDISSCEGEEEEDFLS------LSPSST 802

  Fly  1418 LSLPLTLPLPIAIAPTV------SLPVVSAGVVAPVLAIPSSNINGSDRPPISSWSVEEVSNFIR 1476
            .|    .|.|....|.:      .|||             ..|...|..|  :.|||:||..||.
Zfish   803 FS----CPRPTHCGPQLDDTAPGGLPV-------------DENHFLSGNP--ADWSVQEVCQFIS 848

  Fly  1477 ELPGCQDYVDDFIQQEIDGQALLLLKENHLVNAMGMKLGPALKIVAKVESIKE 1529
            .|.||:|....|:.||||||||:||||.||::.|.:||||||||.|.:.|:::
Zfish   849 SLQGCEDLASQFLSQEIDGQALMLLKEEHLMSTMNIKLGPALKICASINSLRD 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976	38/67 (57%)
ph-d	NP_524794.2	SAM	1464..1529	CDD:197735	37/64 (58%)
phc1	XP_005158395.1	PHC2_SAM_assoc	<763..832	CDD:293222	18/93 (19%)
		SAM_Ph1,2,3	834..901	CDD:188976	38/68 (56%)
		SAM	835..901	CDD:197735	38/67 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7895
eggNOG	1	0.900	-	-		E1_28JS2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6612
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.870