DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-d and phc2b

DIOPT Version :9

Sequence 1:	NP_524794.2	Gene:	ph-d / 44889	FlyBaseID:	FBgn0004860	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_957496.3	Gene:	phc2b / 394177	ZFINID:	ZDB-GENE-040426-1113	Length:	890	Species:	Danio rerio

Alignment Length:	996	Identity:	255/996 - (25%)
Similarity:	392/996 - (39%)	Gaps:	242/996 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   649 IGQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDK 713
            :.|...:...|.|.....:.:|:|......:..|......::|||  |..:..:..::|::....
Zfish    21 VWQRGSRGSKVKHRGGTMEGEQSTPAASASSTTGTSTSTTNSTGT--TSASTASTASSTSSSTSS 83

  Fly   714 QQQ---QLQLF------QKQHILQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVS-QQQQVNAQQ 768
            .:|   |:.::      |...::||.:.:|...|.|..||..|.|.|....|..: |||.::..|
Zfish    84 ARQAVPQISVYSGIPDRQTVQVIQQALNRQPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLSTAQ 148

  Fly   769 QQAVAQQQQAVAQAQQQQREQQQQVAQAQAQHQQALANATQQILQVAPNQFITSHQ--------- 824
            .|::|..||| :.|..:|...|...:..|:...|...|.|   ...|..|.|:..|
Zfish   149 LQSLAAVQQA-SLAAGRQSSNQNGTSSTQSGSSQTTINLT---TSPAAAQLISRAQSVNSAPSGI 209

  Fly   825 QQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQAQQQQQQREQQQNII-------------QQIV-- 874
            .||...|.|.........|||..::||:           .||.|::             .|::
Zfish   210 SQQAVLLGNASSSTLTASQAQMYLRAQM-----------AQQSNLVHVARSLGRAVPLSSQLILA 263

  Fly   875 -------VQQSTGATSQQQQQQPQQQSGQLQ----LSSVPFSVSPSMTAEDIAGITSSALQEALS 928
                   :|..|..|:..|....|.|:..|:    :||.|               .::.|| |||
Zfish   264 PTATVTALQSDTNTTNNTQSASAQVQNLALRNHQGVSSTP---------------QATGLQ-ALS 312

  Fly   929 VSGAIFQTTKPITCSSSTL-PTSSVVTITSQSSTPLVTSSTVASMQQAQTQGTQIHQHQQLISA- 991
            :.    ||  |::...:.| .|.|..|...:::....:|..|...::.||:...::..:.:.|:
Zfish   313 LK----QT--PVSIQPTPLIKTPSQSTGAGKNNLNAASSDGVKKAEEGQTEMKAVNMSRNVSSSH 371

  Fly   992 -TIAGGSQQ--------QQQQQQLGLPSLTPTTPSPTTNPILAMTSMMNATVGHLSTAPPVSVSS 1047
             .||....|        ||.||.:..|..|||:.|   .|.|..|:         |..|....:|
Zfish   372 PLIAPAYAQIQPQALIKQQPQQFVIQPQATPTSRS---QPQLLQTA---------SIQPHQQTAS 424

  Fly  1048 TAVTPSSGQLVTLSSASSGGGAGFPATPTKETPSKGPTATLVPIDSPKTPVSGKDTCTTPKSSTP 1112
            ..: |||.|..|::.                         ::|: .||..:..:.:..|.:
Zfish   425 LGI-PSSAQTSTVTG-------------------------IIPV-LPKPALHNQGSAQTQQ---- 458

  Fly  1113 ATVSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSSTIPNSVSGKE----- 1172
            ||:..|. .|.....||::..|.....|.......|...|::...|..... |.|:..:|
Zfish   459 ATIFHST-VSHHAHTALAHAKAQPVQLTAINLQIQPAQNQASRLAQDDKEK-PTSLVLREICPPV 521

  Fly  1173 --EPKLTTCGS----LTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFTTSCTSTTT 1231
              .|..||.|:    .:.|.:.:.|:.....:..||......::::.|:..||.....:....||
Zfish   522 QIHPSTTTQGTDPPEQSKADTVNATSQTQGSVETAREPTGAQLTSSMTSAVSSEPPPAAVMGNTT 586

  Fly  1232 TTTSSISNGSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKATM--- 1293
                  .||....|:|::||:||||||:||:|||..|||||.|     ..|:.|.|||..|.
Zfish   587 ------QNGENKPPQAIVKPHVLTHVIEGFVIQEGAEPFPVER-----PPVAAESPKKPDTQLPS 640

  Fly  1294 -QEDIKLSGIASAPGSD------------------MVACEQCGKMEHKAKLKR-KRYCSPGCSRQ 1338
             .|....|...||..||                  .:.||.||.::...|.|| ||:||..|:::
Zfish   641 DPEKTASSNSLSATNSDTEEAGQQDTRVEEETEKPKLTCELCGWVDFAHKFKRSKRFCSMVCAKR 705

  Fly  1339 AKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDE---------AMAEEKMQTESY------QTV 1388
            .          ..:.....|:...|.....:::::         ...|.|.|..|.      :::
Zfish   706 Y----------SVSCTKRVGLFRPDRTKSTNQINQWRRRRSHSPRGREAKKQRLSVSQQSQGESI 760

  Fly  1389 SDALPIQAATPEVPPISMPVLAAMSTSSPLSLPLTLPLPIAIAPTVSLPVVSAGVVAPVLAIPSS 1453
            |..|..|.:..|..|.| .:.:....:||||            ...|.||||.||||
Zfish   761 SSPLQSQPSQGESSPCS-DISSYEEATSPLS------------AASSGPVVSQGVVA-------- 804

  Fly  1454 NINGSDRPPISS----------WSVEEVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKENHLVN 1508
             .|..:..|:.|          |:|:||..|||.|||||:..|:|..|||||||||||||:||::
Zfish   805 -ANEPEELPLLSQHFLPCDPTKWNVQEVFEFIRSLPGCQEIADEFRAQEIDGQALLLLKEDHLMS 868

  Fly  1509 AMGMKLGPALKIVAKVESIKE 1529
            ||.:||||||||.|::..:|:
Zfish   869 AMNIKLGPALKIFARINMLKD 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976	42/77 (55%)
ph-d	NP_524794.2	SAM	1464..1529	CDD:197735	41/74 (55%)
phc2b	NP_957496.3	TFIIA	389..>554	CDD:281188	44/209 (21%)
		PHC2_SAM_assoc	708..820	CDD:293222	28/133 (21%)
		SAM_Ph1,2,3	822..889	CDD:188976	40/66 (61%)
		SAM	823..890	CDD:197735	41/67 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594060
Domainoid	1	1.000	88	1.000	Domainoid score	I7895
eggNOG	1	0.900	-	-		E1_28JS2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	192	1.000	Inparanoid score	I3848
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6612
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.850