DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-d and Phc2

DIOPT Version :9

Sequence 1:	NP_524794.2	Gene:	ph-d / 44889	FlyBaseID:	FBgn0004860	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_001013187.2	Gene:	Phc2 / 313038	RGDID:	1307912	Length:	850	Species:	Rattus norvegicus

Alignment Length:	977	Identity:	244/977 - (24%)
Similarity:	376/977 - (38%)	Gaps:	258/977 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   677 VVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQ--QQQLQLF------QKQHILQQQMLQ 733
            |.:.:....:..:|:||     |..:..::::.|...:  ..|:.::      |...::||.:.:
  Rat     7 VPHTSSRASITTNTSGT-----NSSSGCSSSSGGGSGRPTAPQISVYSGIPDRQTVQVIQQALHR 66

  Fly   734 QQIAAIQMQQQQAAVQAQQQQQQQVS-QQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQV-AQA 796
            |...|.|..||..|.|.|....|..: |||.:::.|.|::|..|||...|.:|.......| :||
  Rat    67 QPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLSSAQLQSLAAVQQASLVANRQGSTSGSSVSSQA 131

  Fly   797 QAQHQQ---ALANATQQILQVAP--NQFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQA 856
            .||...   |.:.|..|::..|.  |....|...||...|.|.........|||..::||:
  Rat   132 PAQSSSLNLAASPAAAQLINRAQSVNSATASGLAQQAVLLGNTSSPALTASQAQMYLRAQM---- 192

  Fly   857 QQQQQQREQQQNIIQQIVVQQSTGATSQQQ--QQQPQQQSGQLQLSSVPFSVSPSMTAEDIAGIT 919
                           .|....:|.||.|.:  ...|.:.....|:.::......:..|...|..:
  Rat   193 ---------------LIFTPTATVATVQPELGTGSPARPPTPAQVQNLTLRTQQTPAAAAAAAAS 242

  Fly   920 SSALQEALSVSGAIFQTTKPITCSSSTLPTS----SVV---------TITSQSSTPLVTSS---- 967
            ..|..:.:..|.|:    ||...||..||.:    :||         ::|...:.||.|..
  Rat   243 GPAPTQPVLPSLAL----KPTPSSSQPLPPTPQGRTVVQGSPVGAKPSVTDNVTEPLKTDGNSNM 303

  Fly   968 ------------TVASMQQAQTQGTQIHQHQQLISATIAGGSQQQQQQQQLGLPSLTPTTPSPT- 1019
                        |||:.|......||:..||.|...:......|...|||       |..|.||
  Rat   304 EARPGPDRATVPTVATHQLTAPAYTQLQPHQLLPQPSSKHPQPQFVAQQQ-------PQPPRPTP 361

  Fly  1020 ---TNPILAMTS----MMNATVGH------LSTAPPVSVSSTAV-TPSSGQLVTLSSASSGGGAG 1070
               :.|.||..|    :..:..||      ::.|.|:..|:..| .|.|.|...|.:..||...|
  Rat   362 QVQSQPQLAAVSPSLALQPSPEGHAMPLGPVTQALPLQCSTAHVHKPGSSQQCHLPTPDSGSQNG 426

  Fly  1071 FPATPTKETPSKGP------TATLVPIDSPKTPVSGKDTCTTPKSSTPATVSASVEASSSTGEAL 1129
            .|     |..|..|      |:.::....|.:||        |:...|......|.|..|.
  Rat   427 HP-----EGVSHAPQRRFQHTSAVILQLQPASPV--------PQQCAPDDWKEVVPAEKSV---- 474

  Fly  1130 SNGDASDRSSTPSKGATTPTSKQSNAAVQPPSSTIPNSVSGKEEPKLTTCGSLTSATSTSTTTTI 1194
                          ..|.|.......|:   .:.||..:.|.:.|.:..|    .|..|
  Rat   475 --------------PVTRPGLSPHQQAI---ITAIPGGLPGPKSPNIQQC----PAHET------ 512

  Fly  1195 TNGIGVARTTASTAVSTASTTTTSSGTFTTSCTSTTTTTTSSISNGSKDLPKAMIKPNVLTHVID 1259
              |.|:..         |.|..:|.|..:.:..|.::.|.::..||....|:|::||.:|||||:
  Rat   513 --GQGIVH---------ALTDLSSPGMTSGNGNSASSITGTAPQNGENKPPQAIVKPQILTHVIE 566

  Fly  1260 GFIIQEANEPFPVTR---------QRYADKDVSDEPPKKKATMQEDIKLS----GIASAPGSDM- 1310
            ||:|||..|||||.|         ::||...:.::.|::..|...|.::.    ..:...|:.:
  Rat   567 GFVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKLPQQDHTTTTDSEMEEPYLQESKEEGTPLK 631

  Fly  1311 VACEQCGKMEHKAKLKR-KRYCSPGCSRQAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEA 1374
            :.||.||:::...|.|| ||:||..|:::.     .||..:..||...           ||
  Rat   632 LKCELCGRVDFAYKFKRSKRFCSMACAKRY-----NVGCTKRVGLFHS-----------DR---- 676

  Fly  1375 MAEEKMQ-----TESYQTVSDALPIQAATPEVPPISMPVLAAMSTSSPLSLPLTLPLPIAIAPTV 1434
               .|:|     |.:.:..|.|             |:|.|...:...|..   |:||.:    |.
  Rat   677 ---SKLQKAGTTTHNRRRASKA-------------SLPTLTKDTKKQPSG---TVPLSV----TA 718

  Fly  1435 SLPVV-----------SAGVVAPVLAIPSSNINGSDR--------------------------PP 1462
            :|.:.           ::....|:..|.:|:.....|                          .|
  Rat   719 ALQLAHSQEDSSRCSDNSSYEEPLSPISASSSTSRRRQGQRDLELSDMHMRDLVGMGHHFLPSEP 783

  Fly  1463 ISSWSVEEVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKENHLVNAMGMKLGPALKIVAKVESI 1527
             :.|:||:|..|||.|||||:..::|..|||||||||||||:||::||.:||||||||.|::..:
  Rat   784 -TKWNVEDVYEFIRSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIYARISML 847

  Fly  1528 KE 1529
            |:
  Rat   848 KD 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976	40/67 (60%)
ph-d	NP_524794.2	SAM	1464..1529	CDD:197735	39/64 (61%)
Phc2	NP_001013187.2	PHC2_SAM_assoc	662..780	CDD:293222	24/155 (15%)
		SAM_Ph1,2,3	781..849	CDD:188976	40/68 (59%)
		SAM	783..850	CDD:197735	41/68 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7650
eggNOG	1	0.900	-	-		E1_28JS2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9024
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910