DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-d and Phc1

DIOPT Version :9

Sequence 1:	NP_524794.2	Gene:	ph-d / 44889	FlyBaseID:	FBgn0004860	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	XP_006237362.1	Gene:	Phc1 / 312690	RGDID:	1309203	Length:	1045	Species:	Rattus norvegicus

Alignment Length:	1316	Identity:	320/1316 - (24%)
Similarity:	454/1316 - (34%)	Gaps:	385/1316 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 MLTTTTQNAKQMIGGQAGFAGGNYATCIPSNHNQSPQTVLISPVNVISHSPQQQQNLLQSMAAAA 361
            |.|.:.||:....|..:            |..:..||         |:.....::..:|::.|..
  Rat    31 METESEQNSSSTNGSSS------------SGASSRPQ---------IAQMSLYERQAVQALQALQ 74

  Fly   362 QQQQLTQQQQQQLNQQQ---QQLNQQQQQQQLTAALAKVGVDAQGKLAQKVVQKVTTTSSTVQAA 423
            :|....|...|.:.|||   .||:.....||.|.|.::.........||   |:..||.:::..|
  Rat    75 RQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAASRQASSPNSSTAQ---QQTATTQASINLA 136

  Fly   424 TGPGSTGSTQTQQVQQVQQQQQQTTQTTQQCVQVSQSTLPVGVGGQSVQTAQLLNAGQAQQMQIP 488
            |      ::..|.:.:.|.....:..|..|.|.:..:|.|.            ||..|||....|
  Rat   137 T------TSAAQLISRSQSVSSPSATTLTQSVLLGNTTSPP------------LNQSQAQMYLRP 183

  Fly   489 WFWQNAAGLQPFGSN-----QIILRNQPDGTQGMFIQQQPATQT--LQTQQNQIIQCNVTQTPTK 546
            .........:..|.|     |:||  .|:|......|:.|..|:  :....:|:      |....
  Rat   184 QLGNLLQVNRTLGRNVPLASQLIL--MPNGAVAAVQQEVPPAQSPGVHADADQV------QNLAV 240

  Fly   547 ARTQLDALAPKQQQQQQQ--------VGTTNQTQQQQLAVATAQ-LQQQQQQLTAA--------- 593
            ...|..|..|:.....|:        |...:|...|.||||.|. ...|...|:.|
  Rat   241 RNQQASAQGPQIPGSTQKAIPPGASPVSGLSQASSQALAVAQASGASGQSLNLSQAGGGSGNSLP 305

  Fly   594 ALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKAKMRNKQQPVRPALATLKTEIG-----QVA 653
            ....||.......|....|:|.::......      |.....||: ||..|:....|     :.|
  Rat   306 GSMGPGGGGQAPGGLGQLPSSGLAGGNCPR------KGTGVVQPL-PAAQTVTVSQGSQTEAESA 363

  Fly   654 GQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQQQQL 718
            ...|..|..::  ||....||.:....|.::.::.|.|.|.|...:           :.:||||:
  Rat   364 AAKKAEGDGSS--QQSVGMNLTRTATPAPSQTLISSATYTQIQPHS-----------LIQQQQQI 415

  Fly   719 QLFQKQHILQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQ 783
            .|.|||.::|||:               |:..|||.|.:  |.|.::......:|||||...|.|
  Rat   416 HLQQKQVVIQQQI---------------AIHHQQQFQHR--QSQLLHTATHLQLAQQQQQQQQQQ 463

  Fly   784 QQQREQQQQVAQAQAQHQQALANATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQQQAQAQV 848
            |||::||||..|.|.|.|||...|..|..||.|.|.:...|.|||
  Rat   464 QQQQQQQQQQQQQQQQQQQATTLAAPQPPQVPPTQQVPPSQSQQQ-------------------- 508

  Fly   849 QAQVQAQAQQQQQQREQQQNIIQQIVVQQSTGATSQQQQQQPQQQSGQLQLSSVPFSVSPSMTAE 913
                                 .|.:||             ||..||..|.|...|
  Rat   509 ---------------------AQTLVV-------------QPMLQSSPLSLPPEP---------- 529

  Fly   914 DIAGITSSALQEALSVSGAIFQTTKPITCSSSTLPTSSVVTITSQSSTPL--VTSSTVASMQQAQ 976
                                  |.||              .|..||..|:  :....:.:.:.:.
  Rat   530 ----------------------TPKP--------------PIPIQSKPPVAPIKPPQLGAAKMSA 558

  Fly   977 TQGTQIHQHQQLISATIAGGSQQQQQQQQLGLPSLTPTTPSPTTNPILAMTSMMNATVGHLSTAP 1041
            ||....|...|::.....|.:    |.|.|||..|....|:....|
  Rat   559 TQQPPPHIPVQVVGTRQPGTA----QAQALGLAQLAAAVPTSRGMP------------------- 600

  Fly  1042 PVSVSSTAVTPSSGQLVTLSSASSGGGAGFPATPTKETPSKGPTA-TLVPIDSPKTPVSGKDTCT 1105
                  .||.|....|.:...:|...||      .:|.|....|. ||.|:......|.|..|.:
  Rat   601 ------GAVQPGQAHLASSQPSSQAPGA------LQECPPALATGMTLAPVQGTAHVVKGGPTAS 653

  Fly  1106 TP-KSSTPA--------------TVSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNA 1155
            :| .:..||              |::...:|.|.          .:|....:.|:..|| |.|.|
  Rat   654 SPVVAQVPAAFYMQSVHLPGKAQTLAVKRKAESE----------EEREDLSALGSVLPT-KASPA 707

  Fly  1156 AVQPPSSTIPNSVSGKEEPKLTTCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSG 1220
            |..|......||:..|.||    ..||.                 |....|..|:.|.|
  Rat   708 AESPKVIEEKNSLVEKAEP----VASLN-----------------ANPPNSDLVALAPT------ 745

  Fly  1221 TFTTSCTSTTTTTTSSISN--GSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRY---ADK 1280
                  .|....|.:.:|.  |....|:|::||.:|||:|:||:|||..|||||...::   .:|
  Rat   746 ------PSAPPPTLALVSRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQFLKETEK 804

  Fly  1281 DVSDEPPKKKATMQEDIKLSGIASAPGSD----MVACEQCGKMEHKAKLK-RKRYCSPGCS---- 1336
            .:....|......|....|.|.:.....|    ::.||.|||.....:.: .||:||..|:
  Rat   805 PLPAGLPTGLNESQSGGPLGGDSPCVDLDKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYN 869

  Fly  1337 ----------RQAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTESYQTVSDA 1391
                      |:................|.            .|....:|..|:|.:.::...|:
  Rat   870 VSCSHQFRLKRKKMKEFQEASYARVRRRGP------------RRSSSDIARAKIQGKRHRGQEDS 922

  Fly  1392 LP-------IQAATPEVP-PISMPVLAAMSTSSPLSLPLTLPLPIAIAPTVSLPVVSAGVVAPVL 1448
            ..       .:|.:|..| |:|   :.|......|...:|.|         |.|.:..  :.||.
  Rat   923 SRGSDNSSYDEALSPTSPGPLS---VRAGHGERDLGNTITTP---------STPELQG--INPVF 973

  Fly  1449 AIPSSNINGSDRPPISSWSVEEVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKENHLVNAMGMK 1513
            .  |||       | |.||||||..||..|.|||:..::|..|||||||||||||.||::||.:|
  Rat   974 L--SSN-------P-SQWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIK 1028

  Fly  1514 LGPALKIVAKVESIKE 1529
            |||||||.||:..:||
  Rat  1029 LGPALKICAKINVLKE 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976	42/67 (63%)
ph-d	NP_524794.2	SAM	1464..1529	CDD:197735	41/64 (64%)
Phc1	XP_006237362.1	zf-FCS	833..868	CDD:283998	11/34 (32%)
		PHC2_SAM_assoc	869..975	CDD:293222	20/133 (15%)
		SAM_Ph1,2,3	976..1044	CDD:188976	44/75 (59%)
		SAM	978..1045	CDD:197735	44/68 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5189
eggNOG	1	0.900	-	-		E1_28JS2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3566
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9024
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12247
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.920