Protein Alignment ph-d and Phc3

DIOPT Version :10

• Sequence 1: NP_524794.2
• Gene: ph-d / 44889
• FlyBaseID: FBgn0004860
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: XP_006535530.1
• Gene: Phc3 / 241915
• MGIID: 2181434
• Length: 1009
• Species: Mus musculus
• Alignment Length: 1198
• Identity: 275/1198 - (22%)
• Similarity: 426/1198 - (35%)
• Gaps: 363/1198 - (30%)

  Fly   500 FGSNQIILRNQP-DGTQGMFIQQQPATQTLQTQQN------------------QIIQCNVTQTPT 545
            |..:...:.::| .||..........|.|:.|..:                  |:||..:.:.|:
Mouse     6 FKDHSTAMDSEPSSGTSVSTTASSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPS 70

  Fly   546 KARTQLDALAPKQQQQQQQVGTTNQTQQQQLAVATAQLQQQ----QQQLTAAALQ---RPGAPVM 603
            .|          .|..||...    .|||.|.:.||.||||    .|..:.||:|   ..|.|
Mouse    71 SA----------AQYLQQMYA----AQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRP-- 119

  Fly   604 PHNGTQVRPASSVSTQTAQNQ-SLLK-----AKMRNKQQPVRPALATLKTEIGQVAGQNKVVGHL 662
                 ...|..||:.|::.:| |:|.     |::.|:.|       |..:..|.:..|..::|..
Mouse   120 -----STSPTGSVTQQSSMSQTSILSASPAPAQLMNRSQ-------TSSSTSGSITQQTMLLGST 172

  Fly   663 TTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQQQQLQLFQKQHIL 727
            :......||   |..:.|   :|::.    ||          |.|.|.|   |..:.:.......
Mouse   173 SPTLTASQA---QMYLRA---QMLIF----TP----------ATTVAAV---QSDIPVVSSSPSP 214

  Fly   728 QQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQ 792
            ..|....|:..:.::.|:..|.:..|.....|..|    .|...:...:..|..::..||:...:
Mouse   215 SCQSAAAQVQNLTLRSQKLGVLSSSQNGSPKSAGQ----TQSLTICHNKTTVTSSKISQRDPSPE 275

  Fly   793 VAQAQAQHQQALANA---TQQILQ-VAPNQF--ITSHQQQQQQQL----------HNQLIQQQLQ 841
            ..:..:...::.:.|   |..|.| :||..:  |..|...:.||:          |:||:.||.|
Mouse   276 SKKGGSPGLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPPKVSHHQLLLQQQQ 340

  Fly   842 QQAQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQSTGATSQQQQQQPQQQSGQLQLSSVPFSV 906
            ||.|     .:..|:..|.....      |..:...:.|.:......|||..| .:|....|.:|
Mouse   341 QQIQ-----PITLQSPSQDPPPS------QHCIPLPNHGLSPAPSNAQPQHCS-PVQSHPPPLTV 393

  Fly   907 SPSMTAEDIAGITSSALQEALSVSGAIFQTTKPITCSSSTLPTSSVVTITSQSSTPLVTSS--TV 969
            ||:.         :.:.|:::.||       .|...|.|..||..:.........|||:|:  |.
Mouse   394 SPNQ---------AQSAQQSVVVS-------PPPPHSPSQSPTIIIHPQALIQPHPLVSSALQTG 442

  Fly   970 ASMQQAQTQGTQIHQHQQLISATIAGGSQQQQQQQQLGLPSLTPTTPSPTTNPILAMTSMMNATV 1034
            .::|||                    .:.|.|...||.|||..|...||..:            :
Mouse   443 PNLQQA--------------------AADQVQSTAQLNLPSHLPLPASPVVH------------I 475

  Fly  1035 GHLSTAPPVSVSSTAVTPSSGQLVTLSSASSGGGAGFPATPTKETPSKGPTATLVPIDSPKTPVS 1099
            |.:..:..||.....|:|:|.|..:...:|.                       :||.:|
Mouse   476 GPVQQSALVSPGQQMVSPTSHQQYSALQSSP-----------------------IPIATP----- 512

  Fly  1100 GKDTCTTPKSSTPATVSASVEASSSTGEALSNGD---------------ASDRSSTPSKGATTPT 1149
             .....:|.:..|.....|:::.....|.||.|.               |......|.:....|.
Mouse   513 -PQMSASPPAQLPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQ 576

  Fly  1150 SKQSNAAVQPPSSTIP----------------------NSVSGKEEPKLT-TCGSL--TSATSTS 1189
            :...|..||||:...|                      ..|..:|.|:.: .|..:  |....|.
Mouse   577 TVAVNLQVQPPAPVDPPVGMHLNQCHLHKVFSLKVYQVEDVCEEEMPEESDECARMDRTPPPPTL 641

  Fly  1190 TTTTITNGIG-----------------VARTTASTAVSTASTTTTSS--------GTFTTSCTST 1229
            :...:|.|.|                 ||..:||...|.:..|..|:        ...|.|.:::
Mouse   642 SPAAVTVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPTHASAPAPPLLIPAASTRSSSTS 706

  Fly  1230 TTTTTSSISNGSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKATMQ 1294
            ..::|.|:.|..   |:|::||.:|||||:||:|||..|||||:|...    :.::|.||:..:.
Mouse   707 LASSTPSLENKP---PQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSL----LIEQPVKKRPLLD 764

  Fly  1295 ----------------------------EDIKLSGIASAPGSDMVACEQCGKMEHKAK-LKRKRY 1330
                                        ||:..........|:::.||.||||.:..: |:.||:
Mouse   765 NQVVNSVCVQPELQNNTKHADNSSDTEIEDMMAEETLEEMDSELLKCEFCGKMGYPNEFLRSKRF 829

  Fly  1331 CSPGC-----------------SRQAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEE 1378
            |:..|                 :|:..|...|......:|                  .|..|.|
Mouse   830 CTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSG------------------PEGAARE 876

  Fly  1379 KMQTESYQTVSDALPI--QAATPEVPPISMPVLAAMSTSSPLSLPLTLPLPIAIAPTVSLPVVSA 1441
            .:..:        |||  .:|..:|.....||.:||:|.............:.......:|
Mouse   877 HILRQ--------LPITYPSAEEDVASHEDPVPSAMTTRLRRQSERERERELRDVRIRKMP---- 929

  Fly  1442 GVVAPVLAIPSSNINGSDRPPI-----SSWSVEEVSNFIRELPGCQDYVDDFIQQEIDGQALLLL 1501
                          ..||..|:     |.|:|::|..||..||||||..|:|..|||||||||||
Mouse   930 --------------ENSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDVADEFRAQEIDGQALLLL 980

  Fly  1502 KENHLVNAMGMKLGPALKIVAKVESIKE 1529
            ||:||::||.|||||||||.|::.|:|:
Mouse   981 KEDHLMSAMNMKLGPALKICARINSLKD 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976	43/72 (60%)
Phc3	XP_006535530.1	Atrophin-1	310..>644	CDD:460830	84/422 (20%)
		PAT1	<352..>516	CDD:401645	49/247 (20%)
		SAM_Ph1,2,3	940..1008	CDD:188976	42/67 (63%)