Protein Alignment ph-d and PHC2

DIOPT Version :10

• Sequence 1: NP_524794.2
• Gene: ph-d / 44889
• FlyBaseID: FBgn0004860
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_001372041.1
• Gene: PHC2 / 1912
• HGNCID: 3183
• Length: 881
• Species: Homo sapiens
• Alignment Length: 978
• Identity: 246/978 - (25%)
• Similarity: 369/978 - (37%)
• Gaps: 277/978 - (28%)

  Fly   691 TGTPITLQNGQTLHAATAAGVDKQQQQL--QLFQKQHILQQQMLQQQIAAIQMQQQQAAVQAQQQ 753
            ||..|::.:|..         |:|..|:  |...:|.....|.|||..||   |||...:|....
Human    41 TGPQISVYSGIP---------DRQTVQVIQQALHRQPSTAAQYLQQMYAA---QQQHLMLQTAAL 93

  Fly   754 QQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQVAQAQAQHQQ---ALANATQQILQVA 815
            |||.:|     :||.|...|.||.::...:|.........|||.||...   |.:.|..|:|..|
Human    94 QQQHLS-----SAQLQSLAAVQQASLVSNRQGSTSGSNVSAQAPAQSSSINLAASPAAAQLLNRA 153

  Fly   816 P--NQFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQS 878
            .  |....|...||...|.|.........|||..::||:           .|..|::|   |.:|
Human   154 QSVNSAAASGIAQQAVLLGNTSSPALTASQAQMYLRAQM-----------AQPGNLVQ---VARS 204

  Fly   879 TGATSQQQQQ------------QPQQQSGQLQLSSVPFSVSPSM--TAEDIAGITSSALQ-EALS 928
            .|.|.....|            ||:..:|           ||:.  |...:..:|....| .|.:
Human   205 LGGTVPLSPQLIFTPTATVATVQPELGTG-----------SPARPPTPAQVQNLTLRTQQTPAAA 258

  Fly   929 VSGAIFQTTKPITCSSSTLPTSSVVTITSQSSTPLVTSSTVASMQQAQTQGTQ-------IHQHQ 986
            .||.  ..|:|:..|.:..||..       .|.||.|.:...:..||...|.:       :..|:
Human   259 ASGP--TPTQPVLPSLALKPTPG-------GSQPLPTPAQSRNTAQASPAGAKPGIADSVMEPHK 314

  Fly   987 QLISATIAGGSQQQQQQQQLGLPSLTPTTPSPTTNPILAMT--------SMMNATVGHL------ 1037
            :....:...||.:       |...|:.|.|:...:|::|..        .:...:..||
Human   315 KGDGNSSVPGSME-------GRAGLSRTVPAVAAHPLIAPAYAQLQPHQLLPQPSSKHLQPQFVI 372

  Fly  1038 -------STAPPVSVSS-----------TAVTPSSGQLVTLSSASSGGGAGF-PATPTKETPSKG 1083
                   ...||...|.           .:|:||    |.|..:|....... |.||.  .|.:.
Human   373 QQQPQPQQQQPPPQQSRPVLQAEPHPQLASVSPS----VALQPSSEAHAMPLGPVTPA--LPLQC 431

  Fly  1084 PTATL-VPIDS----PKTPVSGKDTCTTPKSSTP--------------ATVSASVEASSSTGEAL 1129
            |||.| .|..|    |.||.:|      |::..|              :.|...::.:|...:..
Human   432 PTANLHKPGGSQQCHPPTPDTG------PQNGHPEGVPHTPQRRFQHTSAVILQLQPASPVPQQC 490

  Fly  1130 SNGD----ASDRSSTPSKGATTPTSKQSNAAVQPPSSTIPNSVSGKEEPKLTTCGSLTSATSTST 1190
            ...|    |....|.|...:.....:|:.....|....:|.|.:.:..|...|...:..|.:..:
Human   491 VPDDWKEVAPGEKSVPETRSGPSPHQQAIVTAMPGGLPVPTSPNIQPSPAHETGQGIVHALTDLS 555

  Fly  1191 TTTITNGIGVARTTASTAVSTASTTTTSSGTFTTSCTSTTTTTTSSISNGSKDLPKAMIKPNVLT 1255
            :..:|:|.|   .:||:...||.                        .||....|:|::||.:||
Human   556 SPGMTSGNG---NSASSIAGTAP------------------------QNGENKPPQAIVKPQILT 593

  Fly  1256 HVIDGFIIQEANEPFPVTR---------QRYADKDVSDEPPKKKATMQEDIKL-------SGIAS 1304
            |||:||:|||..|||||.|         ::||...:.::.|::..|...|.::       |....
Human   594 HVIEGFVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKLPQQDHTTTTDSEMEEPYLQESKEEG 658

  Fly  1305 APGSDMVACEQCGKMEHKAKLKR-KRYCSPGCSRQAKNGIGGVGSGETNGLGTGGIVGVDAMALV 1368
            ||..  :.||.||:::...|.|| ||:||..|:::.     .||..:..||...
Human   659 APLK--LKCELCGRVDFAYKFKRSKRFCSMACAKRY-----NVGCTKRVGLFHS----------- 705

  Fly  1369 DRLDEAMAEEKMQTESYQTVSDALPIQAATPEVPPISMPVLAAMSTSSPLSLPLTLPL------- 1426
            ||       .|:|.....|.:..   :|:...:||::.......:.:.|||:...|.|
Human   706 DR-------SKLQKAGAATHNRR---RASKASLPPLTKDTKKQPTGTVPLSVTAALQLTHSQEDS 760

  Fly  1427 --------------PIAIAPTVS----------LP------VVSAGVVAPVLAIPSSNINGSDRP 1461
                          ||:.:.:.|          ||      :|..|    ...:||..
Human   761 SRCSDNSSYEEPLSPISASSSTSRRRQGQRDLELPDMHMRDLVGMG----HHFLPSEP------- 814

  Fly  1462 PISSWSVEEVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKENHLVNAMGMKLGPALKIVAKVES 1526
              :.|:||:|..|||.|||||:..::|..|||||||||||||:||::||.:||||||||.|::..
Human   815 --TKWNVEDVYEFIRSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIYARISM 877

  Fly  1527 IKE 1529
            :|:
Human   878 LKD 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976	39/67 (58%)
PHC2	NP_001372041.1	PHA03247	<116..571	CDD:223021	107/510 (21%)
		PHC2_SAM_assoc	693..812	CDD:465202	24/143 (17%)
		SAM_Ph1,2,3	812..880	CDD:188976	40/76 (53%)