DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-d and SAMD11

DIOPT Version :9

Sequence 1:	NP_524794.2	Gene:	ph-d / 44889	FlyBaseID:	FBgn0004860	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_001372569.1	Gene:	SAMD11 / 148398	HGNCID:	28706	Length:	845	Species:	Homo sapiens

Alignment Length:	670	Identity:	137/670 - (20%)
Similarity:	212/670 - (31%)	Gaps:	279/670 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   887 QQQPQQQSGQLQLSSVPFSVSPSMTAEDIAGITSSALQEALSVSGAIFQTTKPITCSSSTLPTSS 951
            :::.:.:|.|.:...:|..:.|||..||......|||.||     :.|:  .|.......||:..
Human   343 EKRARSESPQAEALLLPRELGPSMAPEDHYRRLVSALSEA-----STFE--DPQRLYHLGLPSHD 400

  Fly   952 VVTITSQSSTPLVTSSTVASMQQAQTQGTQIHQHQQLISATIAGGSQQQ--QQQQQLGLPSLTPT 1014
            ::.:..:          ||:.......|.:.|     :.::.||..::|  .|.::...|:..|:
Human   401 LLRVRQE----------VAAAALRGPSGLEAH-----LPSSTAGQRRKQGLAQHREGAAPAAAPS 450

  Fly  1015 -----TPSPTTNPILAMTSMMNATVG-HLSTAPP-VSV-SSTAVTPSSGQLVTLSSASSGGGAGF 1071
                 .|.|.  |:|:..:..:..:| ||  .|| :.| |:...||               |.||
Human   451 FSERELPQPP--PLLSPQNAPHVALGPHL--RPPFLGVPSALCQTP---------------GYGF 496

  Fly  1072 --PATP-----TKETPSKGPTATL-VPID--------SPKTPVSGKDTCTTPKSSTPATVSASVE 1120
              ||..     .:|...|...|.| :|.|        |.:..:...:|...|..        ..|
Human   497 LPPAQAEMFAWQQELLRKQNLARLELPADLLRQKELESARPQLLAPETALRPND--------GAE 553

  Fly  1121 ASSSTGEAL-SNGDASDRSSTPSKGATTPTSKQSNAAVQPPSS--TIPNSVSGKEEPKLTTCGSL 1182
            .....|..| .|..|:...:.|.:|              ||.|  ..|:..|.:..|:
Human   554 ELQRRGALLVLNHGAAPLLALPPQG--------------PPGSGPPTPSRDSARRAPR------- 597

  Fly  1183 TSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFTTSCTSTTTTTTSSISNGSKDLPKA 1247
                        ..|.|.|                                 |:..:.||::..|
Human   598 ------------KGGPGPA---------------------------------SARPSESKEMTGA 617

  Fly  1248 MIKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKATMQEDIKLSGIASAPGSDMVA 1312
            .:                           :|.....|||||.  :..||         |.:..|.
Human   618 RL---------------------------WAQDGSEDEPPKD--SDGED---------PETAAVG 644

  Fly  1313 CEQCGKMEHKAKLKRKRYCSPGCSRQAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAE 1377
            |               |..:||   ||.  .||.|: |..||..|.
Human   645 C---------------RGPTPG---QAP--AGGAGA-EGKGLFPGS------------------- 669

  Fly  1378 EKMQTESYQTVSDALPIQAATPEVPPISMPVLAAMSTSSPLSLPLTLPLPIAIAPTVSLPVVSAG 1442
                                                     :|||..|..::       |....|
Human   670 -----------------------------------------TLPLGFPYAVS-------PYFHTG 686

  Fly  1443 VVAPVLAIPSSNINGSDRP---PISSWSVEEVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEN 1504
                  |:...:::|.:.|   .::.|:|::|.:|:..|.||.:|...|.:|.|||:.|.||.|.
Human   687 ------AVGGLSMDGEEAPAPEDVTKWTVDDVCSFVGGLSGCGEYTRVFREQGIDGETLPLLTEE 745

  Fly  1505 HLVNAMGMKLGPALKIVAKV 1524
            ||:..||:||||||||.|:|
Human   746 HLLTNMGLKLGPALKIRAQV 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976	32/67 (48%)
ph-d	NP_524794.2	SAM	1464..1529	CDD:197735	31/61 (51%)
SAMD11	NP_001372569.1	SAND	113..185	CDD:396076
SAMD11	NP_001372569.1	SAM_Samd7,11	704..771	CDD:188978	31/62 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010