DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ph-d and Phc1

DIOPT Version :9

Sequence 1:	NP_524794.2	Gene:	ph-d / 44889	FlyBaseID:	FBgn0004860	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	XP_006505561.1	Gene:	Phc1 / 13619	MGIID:	103248	Length:	1040	Species:	Mus musculus

Alignment Length:	1303	Identity:	319/1303 - (24%)
Similarity:	462/1303 - (35%)	Gaps:	364/1303 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 MLTTTTQNAKQMIGGQAGFAGGNYATCIPSNHNQSPQTVLISPVNVISHSPQQQQNLLQSMAAAA 361
            |.|.:.||:....|..:            |..:..||         |:.....::..:|::.|..
Mouse    31 METESEQNSSSTNGSSS------------SGASSRPQ---------IAQMSLYERQAVQALQALQ 74

  Fly   362 QQQQLTQQQQQQLNQQQ---QQLNQQQQQQQLTAALAKVGVDAQGKLAQKVVQKVTTTSSTVQAA 423
            :|....|...|.:.|||   .||:.....||.|.|.::.........||   |:..||.:::..|
Mouse    75 RQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAASRQASSPNSSTAQ---QQTATTQASMNLA 136

  Fly   424 TGPGSTGSTQTQQVQQVQQQQQQTTQTTQQCVQVSQSTLPVGVGGQSVQTAQLLNAGQAQQMQIP 488
            |      ::..|.:.:.|.....:..|..|.|.:..:|.|.            ||..|||....|
Mouse   137 T------TSAAQLISRSQSVSSPSATTLTQSVLLGNTTSPP------------LNQSQAQMYLRP 183

  Fly   489 WFWQNAAGLQPFGSN-----QIILRNQPDGTQGMFIQQQPATQTLQTQQNQIIQCNVTQTPTKAR 548
            .........:..|.|     |:||  .|:|......|:.|..|
Mouse   184 QLGNLLQVNRTLGRNVPLASQLIL--MPNGAVAAVQQEVPPAQ---------------------- 224

  Fly   549 TQLDALAPKQQQQQQQVGTTNQTQQQQLAVATAQLQQQQQQLTAAALQRPGA--PVMPHNGTQVR 611
                  :|.......||        |.|||       :.||.:|...|.||:  ..:|...:.|.
Mouse   225 ------SPGVHADADQV--------QNLAV-------RNQQASAQGPQMPGSTQKAIPPGASPVS 268

  Fly   612 PASSVSTQ---TAQNQSLLKAKMRNKQQPVRPALATLKTEIGQVAGQNKVVG-------HLTTVQ 666
            ..|..|:|   .||..|....:..|..|....:..:|...:|...|.....|       .||...
Mouse   269 GLSQTSSQALAVAQASSGASGQSLNLSQAGGGSGNSLPGSMGPGGGGQAPGGLGQLPSSGLTGGS 333

  Fly   667 QQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQTLHAATAA-------GVDKQQQQLQLFQKQ 724
            ..::.|.:.|.:.||           ..:|:..|....|.:||       |..:|...:.|.:..
Mouse   334 CPRKGTGVVQPLPAA-----------QTVTVSQGSQTEAESAAAKKAEADGSGQQSVGMNLTRTA 387

  Fly   725 HILQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQQQREQ 789
            .....|.|           ..:|...|.|....:.||||::.||:|.|.|||.|:..
Mouse   388 TPAPSQTL-----------ISSATYTQIQPHSLIQQQQQIHLQQKQVVIQQQIAIHH-------- 433

  Fly   790 QQQVAQAQAQHQQALANATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQVQA 854
                 |.|.||:|:      |:|..|               .|.||.|||.|||
Mouse   434 -----QQQFQHRQS------QLLHTA---------------THLQLAQQQQQQQ----------- 461

  Fly   855 QAQQQQQQREQQQNIIQQIVVQQSTGATSQQQQQQPQQQSGQLQLSSVPFSVSPSMTAEDIAGIT 919
            |.||||||::|||        ||.|..|:.|..|.|..|           .|.||.:.
Mouse   462 QQQQQQQQQQQQQ--------QQGTTLTAPQPPQVPPTQ-----------QVPPSQSQ------- 500

  Fly   920 SSALQEALSVSGAIFQTTKPITCSSS-TLPTSSVVTITSQSSTPLVTSSTVASMQQAQTQGTQIH 983
                |:|.::      ..:|:..||. |||...    ||:...|:.:...||.::..|....::.
Mouse   501 ----QQAQTL------VVQPMLQSSPLTLPPEP----TSKPPIPIQSKPPVAPIKPPQLGAAKMS 551

  Fly   984 QHQQ---LISATIAGGSQQ-QQQQQQLGLPSLTPTTPSPTTNPILAMTSMMNATVGHLSTAPPVS 1044
            ..||   .|...:.|..|. ..|.|.|||..|....|:|.     .:|..:.....||:::||.|
Mouse   552 ATQQPPPHIPVQVVGTRQPGSAQAQALGLAQLAAAVPTPR-----GITGAVQPGQAHLASSPPSS 611

  Fly  1045 VSSTAVTPSSGQLVTLSSASSGGGAGFPATPTKETPSKGPTATLVPIDSPKTPVSGKDTCTTP-K 1108
            .::                        |....:..|:.....||.|:......|.|..|.::| .
Mouse   612 QAA------------------------PGALQECPPALAAGMTLAPVQGTAHVVKGGPTASSPVV 652

  Fly  1109 SSTPATV---SASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSSTIPNSVSG 1170
            :..||..   |..:...:.|.......::.:.....|..|:...:|.|.||..|......||:..
Mouse   653 AQVPAAFYMQSVHLPGKAQTLAVKRKAESEEERDDLSALASVLPTKASPAAESPKVIEEKNSLGE 717

  Fly  1171 KEEPKLTTCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFTTSCTSTTTTTTS 1235
            |.||    ..||.                 |....|..|:.|.|            .|....|.:
Mouse   718 KAEP----VASLN-----------------ANPPNSDLVALAPT------------PSAPPPTLA 749

  Fly  1236 SISN--GSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRY---ADKDVSDEPPKKKATMQE 1295
            .:|.  |....|:|::||.:|||:|:||:|||..|||||...::   ..|.:....|......|.
Mouse   750 LVSRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQFLKETKKPLQAGLPTGLNESQP 814

  Fly  1296 DIKLSGIASAPG------SDMVACEQCGKMEHKAKLK-RKRYCSPGCS--------------RQA 1339
            ...|.|  .:|.      ::::.||.|||.....:.: .||:||..|:              |:.
Mouse   815 SGPLGG--DSPSVELEKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKK 877

  Fly  1340 KNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTESYQTVSDALP-------IQAA 1397
            ...............|.            .|....:|..|:|.:.::...|:..       .:|.
Mouse   878 MKEFQEASYARVRRRGP------------RRSSSDIARAKIQGKRHRGQEDSSRGSDNSSYDEAL 930

  Fly  1398 TPEVP-PISMPVLAAMSTSSPLSLPLTLPLPIAIAPTVSLPVVSAGVVAPVLAIPSSNINGSDRP 1461
            :|..| |:|   :.|......|...:|.|         |.|.:..  :.||..  |||
Mouse   931 SPTSPGPLS---VRAGHGERDLGNTITTP---------STPELQG--INPVFL--SSN------- 972

  Fly  1462 PISSWSVEEVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKENHLVNAMGMKLGPALKIVAKVES 1526
            | |.||||||..||..|.|||:..::|..|||||||||||||.||::||.:||||||||.||:..
Mouse   973 P-SQWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINV 1036

  Fly  1527 IKE 1529
            :||
Mouse  1037 LKE 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976	42/67 (63%)
ph-d	NP_524794.2	SAM	1464..1529	CDD:197735	41/64 (64%)
Phc1	XP_006505561.1	PHA03247	<509..639	CDD:223021	36/162 (22%)
		PHC2_SAM_assoc	864..970	CDD:374673	20/133 (15%)
		SAM_Ph1,2,3	971..1039	CDD:188976	44/75 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5390
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3713
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8777
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060