DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mdy and DGAT1

DIOPT Version :9

Sequence 1:	NP_609813.1	Gene:	mdy / 44887	FlyBaseID:	FBgn0004797	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_036211.2	Gene:	DGAT1 / 8694	HGNCID:	2843	Length:	488	Species:	Homo sapiens

Alignment Length:	514	Identity:	203/514 - (39%)
Similarity:	287/514 - (55%)	Gaps:	72/514 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GTNGSEKKLRYRRTQSVTRAEEISNKEEKQRRAQPGRPI-------------------------- 119
            |..||.::.|.....|.......:..||:.|.|..|..:
Human     2 GDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWEL 66

  Fly   120 --HRPRDSLFSWSSGFTNFSGLVNWGFLLLCIGGLRLGLENLLKYGIRINPL-----------DW 171
              ||.:|||||..|||:|:.|::||..::|.:...||.||||:||||.::|:           .|
Human    67 RCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSW 131

  Fly   172 FFFISGHNEGEGHNALILSIYSLVHISLCLAVEKGLAMEIIAEGLGLFIQIVNIVVLVCLPVVTI 236
                         .|..|.|.:.|.......|||.||:..:.|..||.:.:.|:..::|.|...:
Human   132 -------------PAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVV 183

  Fly   237 HLKGHAFSLMGASTVCFFYSVLFLKLWSYVQTNMWCRQTYYQKNPRERRPSITLAELKKGVLNGG 301
             |...:.:.:|:......:::|||||:||...|.|||:...:.....::.|...|
Human   184 -LLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAA---------- 237

  Fly   302 EEDEDVSKLVQYPDNLTYKDLLYFLCAPTLCYELNFPRTSRVRKRFLLKRLLEVVIGVNVVMALF 366
                  ...|.|||||||:||.|||.||||||||||||:.|:||||||:|:||::....:.:.|.
Human   238 ------PHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLI 296

  Fly   367 QQWIIPSVRNSLIPFSNMDVALATERLLKLALPNHLCWLCFFYLMFHSFLNAVGELLNFADRNFY 431
            |||::|:::||:.||.:||.:...|||||||:||||.||.|||.:|||.||||.||:.|.||.||
Human   297 QQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFY 361

  Fly   432 CDWWNANNIDTFWRTWNMPVHRWCVRHLYIPVVQMGYSSRQASTIVFLFSAVFHEYLVSVPLQIY 496
            .||||:.::..||:.||:|||:||:||.|.|:::.|.|...|.|.|||.||.||||||||||:::
Human   362 RDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMF 426

  Fly   497 KIWAFMGMMGQIPLSAISKSIEKKLGPRMGNIIVWASIILGQPLCIMAYYHDYVVQHFK 555
            ::|||.|||.||||:..   :.:......||..||.|:|:|||:.::.|.|||.|.:::
Human   427 RLWAFTGMMAQIPLAWF---VGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYE 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mdy	NP_609813.1	MBOAT	115..545	CDD:294479	189/468 (40%)
DGAT1	NP_036211.2	Involved in homomerization. /evidence=ECO:0000250\|UniProtKB:Q9Z2A7	1..91		22/88 (25%)
		Disordered. /evidence=ECO:0000305\|PubMed:32433610	1..57		10/54 (19%)
		MBOAT	70..472	CDD:382173	187/434 (43%)
		Extracellular loop 1 (EL1). /evidence=ECO:0000269\|PubMed:32433610	119..130		0/10 (0%)
		MBOAT fold. /evidence=ECO:0000269\|PubMed:32433610	131..488		167/385 (43%)
		Intracellular loop 1 (IL1). /evidence=ECO:0000269\|PubMed:32433610	224..276		29/67 (43%)
		Intracellular loop 2 (IL2). /evidence=ECO:0000269\|PubMed:32433610	354..399		23/44 (52%)
		FYXDWWN motif. /evidence=ECO:0000303\|PubMed:32433610	360..366		4/5 (80%)
		Acyl-CoA binding. /evidence=ECO:0000269\|PubMed:32433610, ECO:0000269\|PubMed:32433611, ECO:0007744\|PDB:6VP0, ECO:0007744\|PDB:6VYI, ECO:0007744\|PDB:6VZ1	374..382		4/7 (57%)
		Amphipathic helix (AH). /evidence=ECO:0000269\|PubMed:32433610	380..394		9/13 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160118
Domainoid	1	1.000	325	1.000	Domainoid score	I1196
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7688
Inparanoid	1	1.050	389	1.000	Inparanoid score	I2021
Isobase	1	0.950	-	0.650022	Normalized mean entropy	S2132
OMA	1	1.010	-	-		QHG55118
OrthoDB	1	1.010	-	-		D1275897at2759
OrthoFinder	1	1.000	-	-		FOG0003134
OrthoInspector	1	1.000	-	-		oto88930
orthoMCL	1	0.900	-	-		OOG6_101524
Panther	1	1.100	-	-	LDO	PTHR10408
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2034
SonicParanoid	1	1.000	-	-		X3023
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890